A5031593944- Ophthalmology and Eye Disorders
- Pituitary Gland Disorders and Treatments
- Meningioma and schwannoma management
- Cerebral Venous Sinus Thrombosis
- Ophthalmology and Visual Impairment Studies
- Autophagy in Disease and Therapy
- Glaucoma and retinal disorders
- Asphalt Pavement Performance Evaluation
- Infrastructure Maintenance and Monitoring
- Oral and gingival health research
- Signaling Pathways in Disease
- Vascular Malformations Diagnosis and Treatment
- Corneal surgery and disorders
- Intraocular Surgery and Lenses
- Advanced Differential Geometry Research
- Vestibular and auditory disorders
- Ocular Diseases and Behçet’s Syndrome
- Sympathectomy and Hyperhidrosis Treatments
- Teleoperation and Haptic Systems
- Mesenchymal stem cell research
- Advanced Welding Techniques Analysis
- Soft Robotics and Applications
- Cell death mechanisms and regulation
- Intracranial Aneurysms: Treatment and Complications
- Traumatic Ocular and Foreign Body Injuries
Yeungnam University Medical Center
2018-2025
Yeungnam University College
2015-2024
Yeungnam University
2015-2024
Samsung Medical Center
2021-2024
Sungkyunkwan University
2021-2024
Nune Eye Hospital
2020-2024
Pusan National University
2013-2022
Chonnam National University
2006-2021
Hongik University
2017-2021
Kangbuk Samsung Hospital
2020
Recent progress in chemotherapy has significantly increased its efficacy, yet the development of chemoresistance remains a major drawback. In this study, we show that GFRA1/GFRα1 (GDNF family receptor α 1), contributes to cisplatin-induced by regulating autophagy osteosarcoma. We demonstrate cisplatin treatment induced GFRA1 expression human osteosarcoma cells. Induction reduced apoptotic cell death and it survival via autophagy. regulates AMPK-dependent promoting SRC phosphorylation...
ABSTRACT BACKGROUND: The effect of topical corticosteroids after excimer laser photorefractive keratectomy (PRK) remains a matter some controversy. Refractive effects may be different according to the amount myopia and timing instillation. METHODS: Two groups patients were studied: Study A consisted 215 eyes (128 patients) with PRK (mean baseline myopia, -6.53 ± 2.22 D) that received no (No Corticosteroid Group) unless significant regression or corneal haze appeared (Delayed Group), in B, we...
Nitric oxide (NO) is produced by three different isoforms of the enzyme NO synthase (NOS). NOS are expressed in many cell types, including human dental pulp cells (HDPC). acts as an intracellular messenger at physiological levels although it can be cytotoxic higher concentrations. Epigallocatechin gallate (EGCG), a major green tea polyphenol, has diverse pharmacological activities growth and death. This study aimed to investigate apoptotic mechanism effects EGCG on NO-induced apoptosis HDPC....
Nitric oxide (NO) is recognized as a mediator and regulator of inflammatory responses. NO produced by nitric synthase (NOS), NOS abundantly expressed in the human dental pulp cells (HDPCs). can be cytotoxic at higher concentrations to HDPCs. However, mechanism which this pathway activated exposed not known. The purpose study was elucidate NO-induced Sodium nitroprusside (SNP), donor, reduced viability HDPCs dose- time-dependent manner. We investigated vitro effects on apoptosis cultured...
Pancreatic cancer is the worst exocrine gastrointestinal leading to highest mortality. Recent studies reported that aberrant expression of apurinic/apyrimidinic endodeoxyribonuclease 1 (APE1) involved in uncontrolled cell growth. However, molecular mechanism APE1 biological role remains unrevealed pancreatic progression. Here, we demonstrate accelerates proliferation through glial line-derived neurotrophic factor (GDNF)/glial receptor α1 (GFRα1)/Src/ERK axis-cascade signaling. The endogenous...
Periodontitis is an inflammatory disease caused by multiple disease-associated bacterial species in periodontal tissues. Autophagy known to modulate various inflammation-driven diseases and responses, but the role of autophagy related pathogenesis periodontitis not fully established. We investigated whether autophagic flux regulated expression cytokines gingiva patients lipopolysaccharide (LPS)-stimulated human gingival fibroblasts (HGFs) underlying mechanism.The mRNA protein proinflammatory...
In this study, mechanical characteristics of tensile strength ratio (TSR) were evaluated by comparing it to other methods in evaluating moisture sensitivity asphalt mixtures. Twenty types mixtures with and without anti-stripping additives prepared tested the laboratory. Uniaxial compressive (UCS) indirect (IDT) testing conducted determine mixture's cohesion (CR). Determining TSR alone was found be insufficient when resistance. There is a need consider both wet IDT properly evaluate behavior...
Purpose To evaluate parental perspectives and concerns regarding exotropia surgery compare them with clinicians' predictions of responses in Korean pediatric patients intermittent exotropia. Methods This survey study included the parents who underwent clinicians at five hospitals from June 2022 to February 2023, participated Survey Parental Attitude Concerns Exotropia (SPACE) 1. attitudes concern about were assessed using a questionnaire. Clinicians' estimation each item corresponding...
Summary Background Emergence delirium is a common complication of sevoflurane anesthesia in children. Aims We examined the effects maintaining remifentanil infusion during recovery period on incidence emergence preschool‐age children undergoing strabismus surgery under anesthesia. Methods Eighty (aged 3‐7 years) were randomly assigned to either control group (group C; intraoperative infusion) or intervention R; followed by maintenance phase). Intraoperative (0.2 μg/kg/min) was discontinued...
Purpose: To investigate the long-term clinical course of intermittent exotropia after surgical treatment to determine whether and when postoperative exo-drift stabilizes, required postsurgery follow-up duration in cases exotropia.Methods: We retrospectively reviewed medical records patients diagnosed with who underwent between January 1992 2006 at Yeungnam University Hospital postoperatively performed regular examinations for up 7 years.We also analyzed difference stabilization, according...
Nitric oxide (NO) is important in the regulation of bone remodeling, whereas high concentration NO promotes cell death osteoblast. However, it not clear yet whether NO-induced autophagy implicated or survival The present study aimed to examine role MC3T3-E1 cells and their underlying molecular mechanism. effect sodium nitroprusside (SNP), an donor, on cytotoxicity was determined by MTT assay expression apoptosis associated molecules evaluated western blot analysis. morphological observation...
During high tibial osteotomy (HTO), the superficial medial collateral ligament (sMCL) is cut or released at any degree to expose site and achieve targeted alignment correction according surgeon's preference. However, it still unclear whether transection of sMCL increases valgus laxity.We aimed assess outcomes safety transection, especially focusing on iatrogenic instability.Case series; Level evidence, 4.Seventy-two patients (89 knees) who underwent open wedge HTO (MOWHTO) with between...
This study aimed to evaluate changes in the number and clinical characteristics of patients with acute acquired concomitant esotropia (AACE) over course 8 years. retrospective enrolled AACE who visited our clinic between July 2014 June 2022. The total period was divided into 4 periods chronological order. initially underwent surgery compared time by dividing quarters (quarters, 2 years). Clinical factors were analyzed without surgery. Ninety-seven (mean age, 29.5 years; 43 females). Among...
A Multiinstitutional Clinicopathologic StudyWe developed a nomogram to predict the probability of extracapsular extension (ECE) in localized prostate cancer and determine when neurovascular bundle (NVB) may be spared.Total 1,471 Korean men who underwent radical prostatectomy for between 1995 2008 were included.We drew nonrandom samples 1,031 development, leaving 440 validation.With multivariate logistic regression analyses, we made predicts ECE at prostatectomy.Receiver operating...