A5100664047- Prostate Cancer Treatment and Research
- Immune cells in cancer
- Ferroptosis and cancer prognosis
- Cancer Immunotherapy and Biomarkers
- Cell Adhesion Molecules Research
- Immunotherapy and Immune Responses
- Cancer, Lipids, and Metabolism
- Cancer Mechanisms and Therapy
- Phagocytosis and Immune Regulation
- Chemokine receptors and signaling
- Cancer Genomics and Diagnostics
- Radiopharmaceutical Chemistry and Applications
- Hepatocellular Carcinoma Treatment and Prognosis
- Cancer, Stress, Anesthesia, and Immune Response
- Medical Imaging Techniques and Applications
- Cancer, Hypoxia, and Metabolism
- Radiomics and Machine Learning in Medical Imaging
- Cancer-related gene regulation
- Circular RNAs in diseases
- Medicinal Plant Pharmacodynamics Research
- Intracerebral and Subarachnoid Hemorrhage Research
- Neurosurgical Procedures and Complications
- Plant-based Medicinal Research
- Cerebral Venous Sinus Thrombosis
- FOXO transcription factor regulation
Soochow University
2022-2023
First Affiliated Hospital of Soochow University
2022-2023
Xian Yang Central Hospital
2019-2023
University of Michigan–Ann Arbor
2015-2021
Ann Arbor Center for Independent Living
2017-2019
China Jiliang University
2017
Beijing Ditan Hospital
2017
Capital Medical University
2017
Second Military Medical University
2016
Changhai Hospital
2016
Several kinase inhibitors that target aberrant signaling pathways in tumor cells have been deployed cancer therapy. However, their impact on the immune microenvironment remains poorly understood. The tyrosine inhibitor cabozantinib showed striking responses clinical trial patients across several malignancies. Here, we show rapidly eradicates invasive, differentiated PTEN/p53-deficient murine prostate cancer. This was associated with enhanced release of neutrophil chemotactic factors from...
During tumor progression, immune system phagocytes continually clear apoptotic cancer cells in a process known as efferocytosis. However, the impact of efferocytosis metastatic growth is unknown. In this study, we observed that macrophage-driven prostate vitro induced expression proinflammatory cytokines such CXCL5 by activating Stat3 and NF-κB(p65) signaling. Administration dimerizer ligand (AP20187) triggered apoptosis 2 vivo syngeneic models bone which apoptosis-inducible were either...
Systemic lupus erythematosus (SLE) is often associated with exaggerated B cell activation promoting plasma generation, immune-complex deposition in the kidney, renal infiltration of myeloid cells, and glomerular nephritis. Type-I IFNs amplify these autoimmune processes promote severe disease. Bruton's tyrosine kinase (Btk) inhibitors are considered novel therapies for SLE. We describe characterization a highly selective reversible Btk inhibitor, G-744. G-744 efficacious, superior to blocking...
Abstract Endovascular therapy (EVT) is effective in the treatment of large vascular occlusive stroke. However, many factors are associated with outcomes acute ischemic stroke (AIS) after EVT. This study aimed to identify main related prognosis AIS patients We analyzed clinical data neurology department our medical center from June 2017 August 2021 following The included patients’ blood pressure upon admission, glucose concentration, National Institutes Health Stroke Scale (NIHSS) score,...
Wnt signaling has been implicated as a driver of prostate cancer-related osteoblast differentiation, and previous studies have linked modifications in function with the induction tumor metastasis. A unique aspect cancer bone metastases mouse models is their relative predilection to hindlimb (femur) compared forelimb (humerus). Comparative gene expression profiling was performed within humerus femur from non–tumor-bearing mice evaluate differences microenvironments these locations. This...
// Daniel H. Hovelson 1, 2 , Chia-Jen Liu 3 Yugang Wang 4 Qing Kang 5 James Henderson Amy Gursky Scott Brockman 1 Nithya Ramnath John C. Krauss Moshe Talpaz Malathi Kandarpa Rashmi Chugh Missy Tuck Kirk Herman Catherine S. Grasso 10, 11 Michael J. Quist Felix Y. Feng 12 Christine Haakenson 13 Langmore Emmanuel Kamberov Tim Tesmer Hatim Husain 14 Robert Lonigro Dan Robinson 3, 8 David Smith 5, Ajjai Alva Maha Hussain 8, 15 Arul M. Chinnaiyan 10 Muneesh Tewari 2, 6, 7, 9 Ryan E. Mills 7 Todd...
Abstract Rates of progression and treatment response in advanced prostate cancer are highly variable, necessitating non‐invasive methods to assess the molecular characteristics these tumors real time. The unique potential circulating tumor cells (CTCs) serve as a clinically useful liquid biomarker is due their ability inform via both enumeration RNA expression. A microfluidic graphene oxide‐based device (GO Chip) used isolate CTCs CTC clusters from whole blood 41 men with metastatic...
There is evidence that cancer stem-like cells (CSC) and neuroendocrine behavior play critical roles in the pathogenesis clinical course of metastatic castration-resistant prostate (m-CRPC). However, there limited mechanistic understanding how CSC phenotypes impact development m-CRPC. In this study, we explored role intracellular chemokine CXCL12γ induction differentiation its on expression was detected small-cell carcinoma tissues circulating tumor from m-CRPC patients displaying an...
The trend toward precision-based therapeutic approaches dictated by molecular alterations offers substantial promise for men with metastatic castration-resistant prostate cancer (mCRPC). However, current characterization are primarily tissue based, necessitating serial biopsies to understand changes over time and limited the challenges inherent extracting genomic material from predominantly bone metastases. Therefore, a circulating tumor cell (CTC)-based assay was developed determine gene...
While circulating tumor cell (CTC)-based detection of AR-V7 has been demonstrated to predict patient response second-generation androgen receptor therapies, the rarity expression in metastatic castrate-resistant prostate cancer (mCRPC) suggests that other drivers resistance exist. We sought use a multiplex gene platform interrogate CTCs and identify potential markers abiraterone enzalutamide. 37 patients with mCRPC initiating treatment enzalutamide (n = 16) or 21) were prospectively enrolled...
A recent phase III trial of the MET kinase inhibitor cabozantinib in men with castration-resistant prostate cancer (CRPC) failed to meet its primary survival end point; however, most CRPC have intact androgen receptor (AR) signaling. As previous work supports negative regulation by AR signaling, we hypothesized that signaling may limited efficacy some these patients. To assess role on inhibition, first performed an silico analysis human tissue samples stratified status (+ or −), which...
Background and purpose The prevalence of cerebral small vessel disease (CSVD) is increasing due to the accelerating global aging process, resulting in a substantial burden on all countries, as cognitive dysfunction associated with CSVD also rise. Clock genes have significant impact decline dementia. Furthermore, pattern DNA methylation clock strongly impairment. Thus, aim this study was explore connection between promoter PER1 CRY1 patients CSVD. Methods We recruited admitted Geriatrics...
The substantial biological heterogeneity of metastatic prostate cancer has hindered the development personalized therapeutic approaches. Therefore, it is difficult to predict course hormone-sensitive (mHSPC), with some men remaining on first-line androgen deprivation therapy (ADT) for several years while others progress more rapidly. Improving our ability risk-stratify patients would allow optimization systemic therapies and support stratified prospective clinical trials focused likely have...
This study aimed to assess the clinical characteristics of cerebral venous sinus thrombosis (CVT) patients with new-onset headache and identify risk factors for in this population.We retrospectively reviewed demographic data 69 CVT recruited between September 2017 2019. Patients were classified into two groups, group non-headache group, according presence or absence symptoms at admission. The following parameters measured analyzed, including gender, age, amount thromboembolic sinus(ATCVS),...
The aim of the present study was to investigate clinical efficacy phased joint intervention [percutaneous transhepatic variceal embolization (PTVE) + partial splenic (PSE)] in patients with portal hypertension complicated by esophageal bleeding and hypersplenism effect this on interleukin-35 (IL-35)/IL-17 expression. A review 53 caused liver cirrhosis treated conducted, hemodynamics, routine blood examinations function were determined. Quantitative polymerase chain reaction (qPCR) used...
Macrophages play a vital role in maintaining tissue homeostasis through efferocytosis. However, their functional and pathophysiological contribution to the bone metastatic microenvironment remains unclear. Therefore, we investigated efferocytic monocyte/macrophage type its supporting PCa metastasis. FACS analysis revealed that M2 marrow macrophage polarization resulted increased efferocytosis pro‐tumorigenic gene expression. Soluble factors released from cell growth by 30%. Using tumor mouse...
<p>Supplementary Figure Legends</p>
<p>Blockade of neutrophil chemotaxis/infiltration rescues cabozantinib-induced tumor regression.</p>
<p>Dexamethasone attenuates the tumor clearance elicited by cabozantinib.</p>
<p>Increased myeloid CD86-expressing APCs following cabozantinib treatment.</p>