A5065524319- Prostate Cancer Treatment and Research
- Immune cells in cancer
- Cancer-related gene regulation
- Cancer Cells and Metastasis
- Phagocytosis and Immune Regulation
- Wnt/β-catenin signaling in development and cancer
- Global Cancer Incidence and Screening
- Fullerene Chemistry and Applications
- Advanced Chemical Physics Studies
- Cancer-related molecular mechanisms research
- Energetic Materials and Combustion
- Cancer Immunotherapy and Biomarkers
- Dermatologic Treatments and Research
- Systemic Sclerosis and Related Diseases
- MicroRNA in disease regulation
- Boron and Carbon Nanomaterials Research
- Prostate Cancer Diagnosis and Treatment
- Estrogen and related hormone effects
- Cancer Genomics and Diagnostics
- Extracellular vesicles in disease
- Inflammatory Biomarkers in Disease Prognosis
- Cancer, Lipids, and Metabolism
- Speech Recognition and Synthesis
- Circular RNAs in diseases
- Neuroscience and Music Perception
Troy University
2015-2023
University of Michigan
2004-2018
Tuskegee University
2010-2018
Center for Cancer Research
2010-2018
Saint Louis University
2018
Michigan United
2014
Vanderbilt University
2013
Colorado Center for Bone Research
2013
University of Calgary
2012
Alabama State University
2006-2008
# Effect of screening on incidence and mortality from cancer cervix in England: evaluation based routinely collected statistics {#article-title-2} Objective: To assess the impact cervical cancer. Design: Comparison age specific before after introduction national call recall system 1988. Setting: England. Subjects: Women aged over 19 years. Results: From mid-1960s, number smears taken rose continuously to 4.5 million at end 1980s. Between 1988 1994, coverage target group doubled around 85%....
Tumor cells secrete factors that modulate macrophage activation and polarization into M2 type tumor-associated macrophages, which promote tumor growth, progression, metastasis. The mechanisms mediate this are not clear. Macrophages phagocytic participate in the clearance of apoptotic cells, a process known as efferocytosis. Milk fat globule- EGF factor 8 (MFG-E8) is bridge protein facilitates efferocytosis associated with suppression proinflammatory responses. This study investigated...
During tumor progression, immune system phagocytes continually clear apoptotic cancer cells in a process known as efferocytosis. However, the impact of efferocytosis metastatic growth is unknown. In this study, we observed that macrophage-driven prostate vitro induced expression proinflammatory cytokines such CXCL5 by activating Stat3 and NF-κB(p65) signaling. Administration dimerizer ligand (AP20187) triggered apoptosis 2 vivo syngeneic models bone which apoptosis-inducible were either...
Kaiso, a p120 catenin-binding protein, is expressed in the cytoplasmic and nuclear compartments of cells; however, biological consequences clinical implications shift between these have yet to be established. Herein, we report an enrichment Kaiso expression cells primary metastatic prostate tumors relative normal epithelium. Nuclear correlates with Gleason score (P < 0.001) tumor grade 0.001). There higher tumor/normal matched samples from African American men 0.0001). We further found that...
In the tumor microenvironment, CD11b(+)Gr1(+) bone marrow-derived cells are a predominant source of protumorigenic factors such as matrix metalloproteinases (MMP), but how distal tumors regulate these in marrow is unclear. Here we addressed hypothesis that parathyroid hormone-related protein (PTHrP) potentiates prostate hosts. two xenograft models cancer, levels tumor-derived PTHrP correlated with cell recruitment and microvessel density tissue, evidence for mediation cell-derived MMP-9 not...
// Fabiana N. Soki 1 , Sun Wook Cho 2 Yeo Won Kim Jacqueline D. Jones Serk In Park 3,4 Amy J. Koh Payam Entezami Stephanie Daignault-Newton 5 Kenneth Pienta 6 Hernan Roca and Laurie K. McCauley 1,7 Department of Periodontics Oral Medicine, University Michigan School Dentistry, Ann Arbor, MI, USA Internal National Medical Center, Jung-gu, Seoul, Korea 3 Vanderbilt Nashville, TN, 4 Biochemistry Molecular Biology, College Center for Cancer Biostatistics, Michigan, The James Buchanan Brady...
Macrophages play a dual role in regulating tumor progression. They can either reduce growth by secreting antitumorigenic factors or promote progression variety of soluble factors. The purpose this study was to define the monocyte/macrophage population prevalent skeletal tumors, explore mechanism employed supporting prostate cancer (PCa) metastasis, and examine novel therapeutic target. Phagocytic CD68+ cells were found correlate with Gleason score human PCa samples, M2-like macrophages...
To examine trends in prostate cancer incidence and mortality England Wales between 1971 1998, using a newly developed validated national database the database.Age-standardized death rates were calculated directly relative survival among men with registered during 1971-1990 examined.The annual number of new cases increased by 179% 1993, from 6174 to 17 210. Directly age-standardized 104% 29 59 per 100 000. The deaths 113% 4027 8570. 49% 1995 then decreased 8% an overall increase 38% (20 27...
3 Background: The median survival of AIPCA patients (pts) treated with M+P is 10–12 months. Phase I/II trials pts D+E reported survivals 20–23 SWOG 99–16 was designed to compare the M+P. Methods: 770 men progressive were randomized either Arm 1) Dexamethasone 60 mg premedication; D=60 mg/m2 day(D) 2, E= 280 PO D1–5 Q 21 D or 2) M 12 + P 5 BID q D. Pts dose escalated 70 in 1 and 14 mg/m2in 2 if no Grade(G) 4 toxicities observed cycle 1. Assuming 310 eligible each arm, study had 0.80 power...
In a previously published study, we showed that expression of the ABCD3 gene increased with increasing metastatic potential in panel prostate cancer cell lines derived from African American and Caucasian men. Given importance identifying biomarker(s) can distinguish indolent versus aggressive tumors, conducted an immunohistochemical analysis tumors. each patient population was compared clinicopathologic characteristics, Gleason score, age. score (<mml:math...
Molecules consisting entirely or predominantly of nitrogen have been extensively investigated for their potential as high-energy density materials (HEDM). Such molecules react to produce N2 and large amounts energy, but many such are too unstable practical applications. In the present study, cage isomers N8C8H8 studied using theoretical calculations determine structural features that lead most stable cages energetics dissociation various isomers. The evaluated thermodynamic (isomer vs...
Epithelial to mesenchymal transition (EMT) is believed be crucial for primary tumors escape their original residence and invade metastasize. To properly define EMT, there a need ligands that can identify this phenomenon in tumor tissue invivo. A phage-display selection screening was performed select novel binding phage peptides identification of EMT breast cancer. cancer cell line, MCF-7 transformed phenotype by TGF-β treatment used selection. Breast fibroblasts were subtractive depletion...
Cages of carbon and nitrogen have been studied by theoretical calculations to determine the potential these molecules as high-energy density materials. Following previous studies N6C6H6 N8C8H8 cages, a series on several isomers larger N10C10H10 N12C12H12 is carried out relative stability among variety three-coordinate cage with four-membered, five-membered, and/or six-membered rings. Additionally, are same atoms or ions inside cage. Calculations B3LYP PBE1PBE functional (DFT) methods, MP2...
Kaiso, a bi‐modal transcription factor, regulates gene expression and is elevated in breast, prostate, colon cancers. Depletion of Kaiso other cancer types leads to reduction markers for the epithelial– mesenchymal transition (EMT), however, its clinical implications pancreatic ductal adenocarcinoma (PDCA) have not been widely explored. PDCA rarely detected at an early stage but characterized by rapid progression invasiveness. Herein, we report significance subcellular localization PDCAs...
Large nitrogen cage molecules Nx have been previously shown to prefer elongated, cylindrical structures with triangular caps versus more spherical composed entirely of pentagons and hexagons. It was argued that this preference derived from the electronic properties atoms, including lone pairs. In current study, same structural comparison is carried out, substitution C−H-bonding groups for six nitrogens. Various patterns on (triangular) (hexagonal) frameworks are examined. Isomers N18C6H6...
African American (AA) women with breast cancer are more likely to have higher inflammation and a stronger overall immune response, which correlate poorer outcomes. In this report, we applied the nanostring panel identify differences in inflammatory gene expression by race. We observed of multiple cytokines AA patients compared EA patients, high CD47, TGFB1, NFKB1 associated transcriptional repressor Kaiso. To investigate mechanism pattern, that Kaiso depletion results decreased its ligand...