A5081710891- SARS-CoV-2 and COVID-19 Research
- COVID-19 Clinical Research Studies
- Vaccine Coverage and Hesitancy
- COVID-19 Impact on Reproduction
- HIV Research and Treatment
- COVID-19 epidemiological studies
- Immune Cell Function and Interaction
- Microbial Metabolism and Applications
- Reproductive System and Pregnancy
- Drug-Induced Adverse Reactions
- Complement system in diseases
- Kawasaki Disease and Coronary Complications
- HIV/AIDS Research and Interventions
- Antimicrobial Resistance in Staphylococcus
- Heparin-Induced Thrombocytopenia and Thrombosis
- Long-Term Effects of COVID-19
Université Libre de Bruxelles
2021-2024
University of Liège
2021-2024
Case Western Reserve University
1997
University School
1997
Objectives To comprehensively analyze the quality of antibody response between children with Multisystem inflammatory syndrome (MIS-C) and age-matched controls at one month after SARS-CoV-2 exposure, infected in same time-period. Methods Serum from 20 MIS-C admission, 14 control were analyzed. Antigen specific isotypes subclasses directed against various antigens as well human common coronavirus (HCoVs) commensal or pathogenic microorganisms assessed by a bead-based multiplexed serological...
Residents of nursing homes (NHs) are at high risk coronavirus disease 2019 (COVID-19)-related and death may respond poorly to vaccination because old age frequent comorbid conditions.Seventy-eight residents 106 staff members, naive infection or previously infected with severe acute respiratory syndrome (SARS-CoV-2), were recruited in NHs Belgium before immunization 2 doses 30 µg BNT162b2 messenger RNA (mRNA) vaccine days 0 21. Binding antibodies (Abs) SARS-CoV-2 receptor-binding domain...
BackgroundMaternal pertussis vaccination with Tdap vaccine is recommended to protect newborns from severe postnatal infection. HIV-exposed uninfected (HEU) infants have a higher incidence of infection and may particularly benefit maternal immunization. The impact HIV on the quality IgG memory B cell (MBC) responses in pregnant women (PW) living (PWH) unknown.MethodsIn this observational study, humoral immune vaccination, including levels, Fc-dependent effector functions, MBC frequencies,...
Abstract Background The basis of the less severe clinical presentation coronavirus disease 2019 (COVID-19) in children as compared with adults remains incompletely understood. Studies have suggested that a more potent boosting immunity to endemic common cold coronaviruses (HCoVs) may protect children. Methods To test this hypothesis, we conducted detailed analysis antibodies induced by acute respiratory syndrome 2 (SARS-CoV-2) infection aged months 14 years. Results Younger had higher titers...
We examined the relationships among CD4+-T-cell counts, spontaneous apoptosis, and Fas expression peripheral blood mononuclear cells obtained from human immunodeficiency virus type 1 (HIV-1)-infected patients. After 2 days of incubation, propidium iodide DNA staining flow cytometry revealed that subjects with lowest CD4+-cell numbers (0 to 99/microl; n = 20) showed highest frequency apoptosis: 22.4% +/- 2.7% (mean standard error) versus 13.8% 1.2% 12.7% 1.4% patients 100 499 CD4+...
Abstract Background Residents of nursing homes (NH) are at high risk COVID-19 related morbidity and death may respond poorly to vaccination because old age frequent comorbidities. Methods Forty residents forty staff members either naïve or previously infected with SARS-CoV-2 were recruited in two NH Belgium before immunization doses 30µg BNT162b2 mRNA vaccine day 0 21. Binding antibodies (Ab) receptor binding domain (RBD), spike domains S1 S2, RBD Ab avidity, neutralizing against wild type...
Nursing home residents, a frail and old population group, respond poorly to primary mRNA COVID-19 vaccination. A third dose has been shown boost protection against severe disease death in this immunosenescent population, but limited data is available on the immune responses it induces.In observational cohort study, peak humoral cellular were compared 28 days after second doses of BNT162b2 vaccine residents staff members two Belgian nursing homes. Only individuals without evidence previous...
To overcome supply issues of COVID-19 vaccines, this partially single blind, multi–centric, vaccine trial aimed to evaluate humoral immunogenicity using lower doses, intradermal vaccination, and heterologous schedules. Also, the immunity after a booster vaccination was assessed. 566 COVID-19-naïve healthy adults were randomized 1 8 treatment arms consisting combinations BNT162b2, mRNA-1273, ChAdOx1-S. Anti-Receptor-Binding Domain immunoglobulin G (RBD IgG) titers, neutralizing antibody...
IntroductionComorbidities and immunosuppressive therapies are associated with reduced immune responses to primary COVID-19 mRNA vaccination in kidney transplant recipients (KTRs). In healthy individuals, prior SARS-COV-2 infection is increased vaccine responses, a phenotype called hybrid immunity. this study, we explored the potential influence of suppression on immunity KTRs.MethodsEighty-two KTRs, including 59 SARS-CoV-2-naive 23 SARS-CoV-2-experienced patients, were prospectively studied...
Abstract As solid organ recipients are at high risk of severe COVID-19 and respond poorly to primary SARS-CoV-2 mRNA vaccination, they have been prioritized for booster vaccination. However, an immunological correlate protection has not identified in this vulnerable population. We conducted a prospective monocentric cohort study 65 kidney transplant who received three doses BNT162b2 Associations between symptomatic breakthrough infection (BTI) vaccine responses, patient demographic clinical...