A5050258937- Cervical Cancer and HPV Research
- Viral gastroenteritis research and epidemiology
- Hepatitis B Virus Studies
- Viral Infections and Immunology Research
- SARS-CoV-2 and COVID-19 Research
- Vaccine Coverage and Hesitancy
- Hepatitis Viruses Studies and Epidemiology
- Immunotherapy and Immune Responses
- Molecular Biology Techniques and Applications
- Viral Infections and Outbreaks Research
- Cytokine Signaling Pathways and Interactions
- Influenza Virus Research Studies
- Animal Virus Infections Studies
- Reproductive tract infections research
- Virology and Viral Diseases
- Infection Control in Healthcare
- COVID-19 Clinical Research Studies
- Viral Infections and Vectors
- Drug-Induced Adverse Reactions
- Disaster Response and Management
- Vector-Borne Animal Diseases
- Heparin-Induced Thrombocytopenia and Thrombosis
- Respiratory viral infections research
- RNA and protein synthesis mechanisms
- Immunodeficiency and Autoimmune Disorders
University of Antwerp
2014-2025
Infectious Diseases Institute
2019
The live-attenuated oral poliovirus vaccine (OPV or Sabin vaccine) replicates in gut-associated tissues, eliciting mucosa and systemic immunity. OPV protects from disease limits spread. Accordingly, vaccination with is the primary strategy used to end circulation of all polioviruses. However, ability regain replication fitness establish new epidemics represents a significant risk polio re-emergence should immunization cease. Here, we report development type 2 strain (nOPV2) that genetically...
Use of oral live-attenuated polio vaccines (OPV), and injected inactivated (IPV) has almost achieved global eradication wild viruses. To address the goals achieving maintaining minimising risk outbreaks vaccine-derived polioviruses, we tested novel monovalent type-2 poliovirus (OPV2) vaccine candidates that are genetically more stable than existing OPVs, with a lower reversion to neurovirulence. Our study represents first in-human testing these two OPV2 candidates. We aimed evaluate safety...
Two novel type 2 oral poliovirus vaccine (OPV2) candidates, OPV2-c1 and OPV2-c2, designed to be more genetically stable than the licensed Sabin monovalent OPV2, have been developed respond ongoing polio outbreaks due circulating vaccine-derived polioviruses.We did two randomised studies at centres in Belgium. The first was a phase 4 historical control study of OPV2 Antwerp, done before global withdrawal second Antwerp Ghent with OPV2-c2. Eligible participants were healthy adults aged 18-50...
Typhoid fever causes more than 21 million cases of disease and 200,000 deaths yearly worldwide, with 90% the burden being reported from Asia. Epidemiological data show high incidence in young children suggest that immunization programs should target below two years age: this is not possible available vaccines. The Novartis Vaccines Institute for Global Health developed a conjugate vaccine (Vi-CRM₁₉₇) infant vaccination concomitantly EPI vaccines, either starting at 6 weeks DTP or 9 months...
We investigated safety and immunogenicity of 1-2 doses different bivalent virus-like particle (VLP) norovirus vaccine candidate (NoV) formulations in healthy 18- to 64-year-olds.On days 1 28, participants (n = 420) randomized 14 equal groups received intramuscular control (hepatitis A) or 11 NoV containing varying dosages GI.1 GII.4c genotype VLP antigens with aluminum hydroxide [Al(OH)3], 0 μg, 15 50 μg monophosphoryl lipid A (MPL). Immunogenicity was assessed on 1, 56, 208 393. Solicited...
Post hoc analyses of 9-valent human papillomavirus (9vHPV) vaccine immunogenicity were conducted in five Phase 3 studies that enrolled males. Month 7 antibody geometric mean titers (GMTs) after three 9vHPV doses analyzed 10,024 males/females aged 16–26 years from 001 (NCT00543543), 002 (NCT00943722), 003 (NCT01651949), and 020 (NCT02114385). Covariates considered age, gender, sexual orientation, region residence, race. GMTs among 2599 9–15 (studies 010 [NCT01984697]) assessed 6 months one,...
Simplified vaccine preparation steps would save time and reduce potential immunisation errors. The aim of the study was to assess with fully-liquid hexavalent (DTaP-IPV-HB-PRP-T, Sanofi Pasteur MSD) versus non-fully liquid that needs reconstitution (DTPa-HBV-IPV/Hib, GlaxoSmithKline Biologicals).Ninety-six Health Care Professionals (HCPs) participated in a randomised, cross-over, open-label, motion Belgium (2014). HCPs prepared each cross-over manner wash-out period 3-5min. An independent...
Abstract Purpose: Women infected with human papillomavirus (HPV) normal cytology to mild abnormalities currently have no treatment options other than watchful waiting or surgery if high-grade cervical lesions cancer develop. A therapeutic vaccine would offer the possibility of preventing in HPV-infected women. GTL001 is a composed recombinant HPV16 and HPV18 E7 proteins fused catalytically inactive Bordetella pertussis CyaA. This study examined tolerability immunogenicity women cytology....
Sabin-strain oral polio vaccines (OPV) can, in rare instances, cause disease recipients and susceptible contacts or evolve to become circulating vaccine-derived strains with the potential outbreaks. Two novel type 2 OPV (nOPV2) candidates were designed stabilize genome against rapid reversion that is observed following vaccination Sabin (mOPV2). Next-generation sequencing a modified transgenic mouse neurovirulence test applied shed nOPV2 viruses from phase 1 studies mOPV2 4 study. The...
Abstract Assessment of humoral immune responses following human papillomavirus (HPV) vaccination currently relies on invasive blood sampling. This longitudinal cohort study explores the usability first‐void urine as a noninvasive alternative sample for antibody detection. In this study, 58 women receiving three doses 9vHPV vaccine within Gardasil9 (9vHPV) Phase III randomized controlled trial were included. Participants provided paired and samples before (M0), 1 month after third dose (M7),...
The link between infection with high-risk human papillomavirus (hrHPV) and cervical cancer has been clearly demonstrated. Virological end-points showing the absence of persistent HPV are now accepted as a way monitoring impact prophylactic vaccination programs therapeutic vaccine trials. This study investigated use urine samples, which can be collected by self-sampling at home, instead samples for follow-up an intervention trial. Eighteen initially DNA-positive women participating in trial...
Abstract Background OVX836 is a recombinant protein vaccine targeting the highly conserved influenza nucleoprotein (NP), which could confer broad-spectrum protection against this disease. Methods A randomized, placebo-controlled, double-blind, dose-escalating, single- center, first-in-human study was conducted in 36 healthy adults aged 18–49 years. Twelve subjects per cohort (9 and 3 placebo) received 2 intramuscular administrations on days 1 28 at dose level of 30 µg, 90 or 180 µg. Safety...
Inactivated trivalent poliovirus vaccine (IPV) induces humoral immunity, which protects against paralytic poliomyelitis but does not induce sufficient mucosal immunity to block intestinal infection. We assessed the in healthy adults Belgium conferred by a co-formulation of IPV with adjuvant double mutant Labile Toxin (dmLT) derived from Escherichia coli.Healthy fully IPV-vaccinated 18-45-year-olds were randomly allocated three groups: on Day 1 two groups received one full dose (n = 30) or +...
Background: The pediatric dose of the virosomal hepatitis A vaccine Epaxal®, Epaxal® Junior, is safe and immunogenic in children from 1 to 17 years age. present study investigated long-term immunogenicity Junior. standard doses aluminum-adsorbed (Havrix® Junior) were used as comparators. Methods: total 271 who had completed a 0/6-month immunization schedule (priming booster dose) participated this follow-up study. Anti-hepatitis virus (HAV) antibody levels measured using microparticle enzyme...
To overcome supply issues of COVID-19 vaccines, this partially single blind, multi–centric, vaccine trial aimed to evaluate humoral immunogenicity using lower doses, intradermal vaccination, and heterologous schedules. Also, the immunity after a booster vaccination was assessed. 566 COVID-19-naïve healthy adults were randomized 1 8 treatment arms consisting combinations BNT162b2, mRNA-1273, ChAdOx1-S. Anti-Receptor-Binding Domain immunoglobulin G (RBD IgG) titers, neutralizing antibody...
Although global polio eradication is within reach, sustained of all polioviruses requires cessation oral poliovirus vaccine use to mitigate against vaccine-derived circulation and vaccine-associated paralytic poliomyelitis. The first step in this direction was the WHO-recommended withdrawal live attenuated type 2 Sabin from routine immunisation May 2016, with future restricted outbreak response, handling controlled by strict containment provisions (GAPIII). This creates unique challenges for...
In a blinded phase 1 trial (EudraCT 2017-0000908-21; NCT03430349) in Belgium, healthy adults (aged 18-50 years) previously immunized exclusively with inactivated poliovirus vaccine were administered single dose of 2 novel type oral vaccines (nOPV2-c1: S2/cre5/S15domV/rec1/hifi3 (n = 15); nOPV2-c2: S2/S15domV/CpG40 15)) and isolated for 28 days purpose-built containment facility. Using stool samples collected near 0, 14, 21, 28, we evaluated intestinal neutralization immunoglobulin A...
Background: To overcome supply issues of COVID-19 vaccines, this partially single blind, multicentric, vaccine trial aimed to evaluate humoral immunity using lower doses, intradermal vaccination and heterologous schedules. Also, the after a booster was assessed.Methodology: 566 naïve healthy adults were randomized 1 8 treatment arms consisting combinations BNT162b2, mRNA-1273 ChAdOx1-S. Anti-Receptor-Binding Domain immunoglobulin G (RBD IgG) titers, neutralizing antibody titres avidity...
Recent studies demonstrated that human papillomavirus (HPV) specific immunoglobulins (IgG) are present and detectable in non-invasively collected first-void urine (FVU) samples. As IgG levels low, we evaluated the potential of a highly sensitive HPV16-specific assay based on time-resolved fluorescence, DELFIA, compared it with three immunoassays, GST-L1-MIA, M4ELISA, M9ELISA. A total 225 paired serum FVU samples from two cohorts healthy female volunteers were analyzed. Strong Spearman rank...
<h3>Background and aims</h3> Simplified vaccine preparation steps would save time reduce the potential of mishandlings. The aim study was to assess with fully liquid hexavalent (DTaP-IPV-HB-PRP-T, Sanofi Pasteur MSD, Lyon, France) versus that needs reconstitution (DTPa-HBV-IPV/Hib, GlaxoSmithKline Biologicals, Rixensart, Belgium). <h3>Methods</h3> 96 Health Care Professionals (HCPs) participated in a randomised, cross-over, open-label, Time Motion Belgium (2014). HCPs prepared each (time...