A5038707104- Cervical Cancer and HPV Research
- Reproductive tract infections research
- SARS-CoV-2 and COVID-19 Research
- COVID-19 Clinical Research Studies
- Adolescent Sexual and Reproductive Health
- Hepatitis B Virus Studies
- Vaccine Coverage and Hesitancy
- Second Language Learning and Teaching
- Linguistic Education and Pedagogy
- Immunotherapy and Immune Responses
- Health Systems, Economic Evaluations, Quality of Life
- Linguistic research and analysis
- Urinary Tract Infections Management
- Acute Ischemic Stroke Management
- Intracranial Aneurysms: Treatment and Complications
- Histone Deacetylase Inhibitors Research
- Sarcoma Diagnosis and Treatment
- Health and Medical Education
- Plant and Fungal Interactions Research
- HIV/AIDS oral health manifestations
- Breast Lesions and Carcinomas
- Health and Lifestyle Studies
- Neurological Complications and Syndromes
- Gestational Trophoblastic Disease Studies
- Peanut Plant Research Studies
Universidad del Desarrollo
2015-2025
Clínica Alemana
2009-2025
University of Münster
2023
Pontificia Universidad Católica de Chile
1994-2022
University Hospital Carl Gustav Carus
2018-2020
Khon Kaen University
2016
Adolescent Health Clinic
2011
Springer Nature (Germany)
2011
Hospital Padre Hurtado
2009
BACKGROUND: This study in 11- to 15-year-old boys and girls compared the immunogenicity safety of GARDASIL 9 (9-valent human papillomavirus [9vHPV] vaccine) administered either concomitantly or nonconcomitantly with 2 vaccines routinely this age group (Menactra [MCV4; Neisseria meningitidis serotypes A/C/Y/W-135] Adacel [Tdap; diphtheria/tetanus/acellular pertussis]). METHODS: Participants received 9vHPV vaccine at day 1 months 6; concomitant (n = 621) MCV4/Tdap 1; nonconcomitant 620) month...
Post hoc analyses of 9-valent human papillomavirus (9vHPV) vaccine immunogenicity were conducted in five Phase 3 studies that enrolled males. Month 7 antibody geometric mean titers (GMTs) after three 9vHPV doses analyzed 10,024 males/females aged 16–26 years from 001 (NCT00543543), 002 (NCT00943722), 003 (NCT01651949), and 020 (NCT02114385). Covariates considered age, gender, sexual orientation, region residence, race. GMTs among 2599 9–15 (studies 010 [NCT01984697]) assessed 6 months one,...
The purpose of this study was to compare the long-term psychosocial adaptation Hodgkin's disease and adult acute leukemia survivors.Two hundred seventy-three (HD) 206 (AL) survivors were interviewed by telephone concerning their adjustment problems they attributed having been treated for cancer, using identical research procedures a common set instruments. following measures used: Psychosocial Adjustment Illness Scale (PAIS); Brief Symptom Inventory (BSI); current Conditioned Nausea Vomiting...
Multiple vaccines against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) have been evaluated in clinical trials. However, trials addressing the immune response pediatric population are scarce. The inactivated vaccine CoronaVac has shown to be safe and immunogenic a phase 1/2 trial cohort China. Here, we report interim safety immunogenicity results of 3 for healthy children adolescents Chile. Participants 17 years old received two doses 4-week interval until 31 December 2021....
BackgroundThe Omicron variant has challenged the control of COVID-19 pandemic due to its immuno-evasive properties. The administration a booster dose SARS-CoV-2 vaccine showed positive effects in immunogenicity against SARS-CoV-2, effect that is even enhanced after second booster.MethodsDuring phase-3 clinical trial, we evaluated CoronaVac®, an inactivated administered 6 months first booster, neutralization (n = 87). In parallel, cellular immunity 45) was analyzed stimulated peripheral...
<h3>Objective:</h3> To investigate the effects of medical vs interventional management on functional outcome in A Randomized Trial Unruptured Brain Arteriovenous Malformations (ARUBA). <h3>Methods:</h3> We used initial results a nonblinded, randomized, controlled, parallel-group trial involving adults ≥18 years age with an unruptured brain arteriovenous malformation (AVM) to compare (MM) or without therapy (IT) impairment, defined by primary death symptomatic stroke causing modified Rankin...
Chlamydia trachomatis and Neisseria gonorrhoeae are common sexually transmitted diseases among young women little has been doing to study them in Chilean adolescents.Determine the rates of C N women.Urine samples were obtained from 203 active females under 25 year-old, who attended hospitals either high or low-income areas Chile's capital, Santiago. Ngonorrhoeae detected by nucleic acid amplification testing.Seven percent positive for trachomatis. AU negative gonorrhoeae. Among pregnant...
Human papillomavirus (HPV) antibody responses to the 9-valent human (9vHPV) vaccine among girls and boys (aged 9-14 years) receiving 2-dose regimens (months 0, 6 or 12) were noninferior a 3-dose regimen 2, 6) in young women 16-26 4 weeks after last vaccination an international, randomized, open-label trial (NCT01984697). We assessed response durability through month 36.Girls received 2 0 [0, 6]: n = 301; months 12 12]: 151) 3 doses 0,2, 301); ([0, 150); 314) of 9vHPV vaccine. Anti-HPV...
Several vaccines have been developed to control the COVID-19 pandemic. CoronaVac®, an inactivated SARS-CoV-2 vaccine, has demonstrated safety and immunogenicity, preventing severe cases. We investigate non-inferiority of two immunization schedules CoronaVac® in a trial healthy adults. A total 2302 adults were enrolled at 8 centers Chile randomly assigned vaccination schedules, receiving doses with either 14 or 28 days between each. The primary efficacy endpoints solicited adverse events...
OBJECTIVE To prospectively assess, using a questionnaire‐based study, the relative differences and changes in urinary continence bowel symptoms, need for further surgery, within first year after radical retropubic prostatectomy (RRP) patients with no adjuvant radiotherapy (aRT). PATIENTS AND METHODS The study included 96 men clinically organ‐confined adenocarcinoma of prostate who underwent RRP between March 1998 June 1999. A subset 36 was recommended aRT prostatic fossa (median dose 54 Gy)...
The choice of drug treatment in advanced soft tissue sarcoma (STS) continues to be a challenge regarding efficacy, quality life (QoL) and toxicity. Unlike other cancer types, where integrating patient-reported outcomes (PRO) has proven beneficial for QoL, there is no such evidence patients with STS as now. YonLife trial aimed explore the effect tailored multistep intervention on symptoms survival undergoing trabectedin well identifying predictors QoL. cluster-randomised, open-label,...
Abstract Background Multiple vaccines against SARS-CoV-2 have been evaluated in clinical trials, but very few include the pediatric population. The inactivated vaccine CoronaVac ® has shown to be safe and immunogenic a phase 1/2 trial cohort China. This study is an interim safety immunogenicity report of 3 for healthy children adolescents Chile. Methods Participants aged 17 years old received two doses four-week interval. Local systemic adverse reactions were registered 699 participants that...
En este artículo práctico, en base a preguntas y respuestas, se abordan las principales consultas formuladas los especialistas, tales como ¿Porqué vacunar contra VPH? ¿Composición de la vacuna? ¿Cuáles son su eficacia seguridad? ¿Deben vacunarse varones? varias otras.
As alternative for patients that fear genital examination, we assessed adolescent's comfort and ease with self-collected samples nucleic acid amplification testing sexually transmitted infections.Sexually active Chilean adolescents youth under 25 years (174 males 117 females) were enrolled. Females used vaginal swabs collected first-stream urine. A satisfaction survey evaluating self-sampling system was applied.Self-collection considered easy in 99.3% of the interviewees (CI 95% 0.88-0.98)....
During the COVID-19 pandemic, importance of vaccinating children against SARS-CoV-2 was rapidly established. This study describes safety CoronaVac® in and adolescents between 3- 17-years-old a multicenter Chile with two vaccine doses 4-week interval. For all participants, immediate adverse events (AEs), serious AEs (SAEs), special interest (AESIs) were registered throughout study. In subgroup, recorded 28 days after each dose. surveillance performed A total 1139 individuals received first...
Zusammenfassung Der Beitrag setzt sich mit der Frage auseinander, welche diskursiven Merkmale charakteristisch für die Wissensvermittlung in Einführungsvorlesungen sind, um daraus sprachlichen Anforderungen an Rezeption abzuleiten. Grundlage funktionalpragmatischen linguistischen Analyse bilden Datenbank Gesprochenes Deutsch (DGD) veröffentlichte Transkripte und Aufnahmen. In einem zweiten Schritt werden diese Charakteristika Lehrwerksmaterialien zum Hörverstehen verglichen,...