A5006244396- Helminth infection and control
- Parasites and Host Interactions
- Parasite Biology and Host Interactions
- Animal testing and alternatives
- Coccidia and coccidiosis research
- Veterinary Pharmacology and Anesthesia
- Pharmacogenetics and Drug Metabolism
- Pharmacological Effects and Assays
- Veterinary Equine Medical Research
- Plant and fungal interactions
- Pesticide Residue Analysis and Safety
- Animal health and immunology
- Poisoning and overdose treatments
- Drug Transport and Resistance Mechanisms
- Drug-Induced Hepatotoxicity and Protection
- Drug-Induced Adverse Reactions
- Ruminant Nutrition and Digestive Physiology
- Anesthesia and Pain Management
- Veterinary Oncology Research
- Exercise and Physiological Responses
- Pharmacological Effects and Toxicity Studies
- Microbial infections and disease research
- Molecular Biology Techniques and Applications
- Spectroscopy Techniques in Biomedical and Chemical Research
- Plant Toxicity and Pharmacological Properties
Consejo Nacional de Investigaciones Científicas y Técnicas
2014-2024
Universidade de São Paulo
2024
Universidad Nacional del Centro de la Provincia de Buenos Aires
2016-2024
University of Saskatchewan
2023-2024
Centro Científico Tecnológico - Tandil
2014-2021
Multiple vaccines against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) have been evaluated in clinical trials. However, trials addressing the immune response pediatric population are scarce. The inactivated vaccine CoronaVac has shown to be safe and immunogenic a phase 1/2 trial cohort China. Here, we report interim safety immunogenicity results of 3 for healthy children adolescents Chile. Participants 17 years old received two doses 4-week interval until 31 December 2021....
The family of ATP ‐binding cassette ( ABC ) transporters is composed several transmembrane proteins that are involved in the efflux a large number drugs including ivermectin, macrocyclic lactone ML endectocide, widely used human and livestock antiparasitic therapy. aim work reported here was to assess interaction between three different anthelmintic with substrates P‐glycoprotein (P‐gp) breast cancer resistance protein BCRP ). ability ivermectin IVM ), moxidectin MOX closantel CST modulate...
Combinations of bioactive phytochemicals with synthetic compounds have been suggested as promissory tools for the improvement nematode control in livestock. Bioactive may interfere activity drug-metabolizing enzymes and delay metabolic conversion anthelmintics into less potent metabolites.This research assessed effect monoterpene thymol (TML) on vitro hepatic metabolism anthelmintic albendazole (ABZ) sheep.Liver microsomes from four (4) Texel lambs were incubated ABZ (50 µM) absence or...
Monepantel (MNP) is a new amino-acetonitrile derivative anthelmintic drug used for the treatment of gastrointestinal (GI) nematodes in sheep. The present work investigated main enzymatic pathways involved hepatic biotransformation MNP sheep and cattle. metabolic stability ruminal fluid both parent its metabolite (monepantel sulphone, MNPSO2 ) was characterized as well. Additionally, relative distribution molecules between particulate phases content studied. Liver microsomal fractions from...
Monepantel (MNP) is a novel anthelmintic compound launched into the veterinary pharmaceutical market. MNP not licenced for use in dairy animals due to prolonged elimination of its metabolite monepantel sulphone (MNPSO2 ) milk. The goal this study was evaluate presence potential vivo drug-drug interactions affecting pattern milk excretion after coadministration anthelmintics and oxfendazole (OFZ) lactating cows. concentrations both parent drugs their metabolites were measured plasma samples...
1. Precision-cut liver slices (PCLS) from food-producing animals have not been extensively used to study xenobiotic metabolism, and thus information on this field of research is sparse. 2. The aims the present work were further validate technique production culture bovine PCLS characterize metabolic interaction between anthelmintic albendazole (ABZ) flavin-monooxygenase (FMO) inhibitor methimazole (MTZ). 3. Nine steers as donors. produced incubated under two methods: a dynamic organ (DOC)...
Parasitic diseases have a significant impact on livestock production. Nematodicidal drugs, such as fenbendazole (FBZ) or its oxidized metabolite oxfendazole (OFZ), can be used along with the trematodicidal triclabendazole (TCBZ), to broaden spectrum of anthelmintic activity. However, co-exposure these compounds could lead drug-drug (D-D) interactions and eventually alter clinical profile each active principle. The aim this study was assess presence by means two in vitro models, namely bovine...
A mass was removed surgically from the right orbit of a 1-d-old Holstein calf. Grossly, filled rostral part an enlarged and compressed globe toward caudal pole orbit. The brown, 6-cm tumor had central yellow brown areas, smooth, glistening cut surface. Microscopically, neoplasm highly cellular composed spindle cells arranged in irregular, broad, interlacing streams bundles, forming herringbone pattern supported by sparse collagenous matrix. Neoplastic infiltrated surrounding soft tissues...
In vitro systems are useful tools for unravelling species differences in xenobiotic metabolism.The current work aimed to validate the technique of precision-cut liver slices (PCLS) comparative studies on metabolism swine and cattle.PCLS from (n = 3) cattle were produced using a Brendel-Vitron