A5102776023- SARS-CoV-2 and COVID-19 Research
- COVID-19 Clinical Research Studies
- Natural Compounds in Disease Treatment
- Dermatology and Skin Diseases
- Hepatitis B Virus Studies
- Biomedical Text Mining and Ontologies
- Topic Modeling
- Hepatitis C virus research
- Natural Language Processing Techniques
- Hedgehog Signaling Pathway Studies
- Climate variability and models
- Liver Disease Diagnosis and Treatment
- Viral gastroenteritis research and epidemiology
- COVID-19 Impact on Reproduction
- Oceanographic and Atmospheric Processes
- Viral Infections and Immunology Research
- SARS-CoV-2 detection and testing
- Psoriasis: Treatment and Pathogenesis
- Evaluation Methods in Various Fields
- Vaccine Coverage and Hesitancy
- Whipple's Disease and Interleukins
- Medicine and Dermatology Studies History
- Pregnancy and Medication Impact
- vaccines and immunoinformatics approaches
- Inhalation and Respiratory Drug Delivery
Sinovac Biotech
2020-2024
Weihai Municipal Hospital
2024
First Affiliated Hospital of Zhengzhou University
2024
Weatherford College
2024
University of Oxford
2023
Ocean University of China
2023
Yueyang Hospital
2019-2021
Shanghai University of Traditional Chinese Medicine
2019-2021
Dartmouth College
2019
Kingmed Diagnostics
2017
Multiple vaccines against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) have been evaluated in clinical trials. However, trials addressing the immune response pediatric population are scarce. The inactivated vaccine CoronaVac has shown to be safe and immunogenic a phase 1/2 trial cohort China. Here, we report interim safety immunogenicity results of 3 for healthy children adolescents Chile. Participants 17 years old received two doses 4-week interval until 31 December 2021....
Radiologists are expected to expediently communicate critical and unexpected findings referring clinicians prevent delayed diagnosis treatment of patients. However, competing demands such as heavy workload along with lack administrative support resulted in communication failures that accounted for 7% the malpractice payments made from 2004 2008 United States. To address this problem, we have developed a novel machine learning method can automatically accurately identify cases require prompt...
Abstract Prediction of El Niño–Southern Oscillation (ENSO) is hindered by a spring predictability barrier (SPB). In this paper, we investigate the effects Indian Ocean (IO) on SPB. Using seasonally varying extended IO–ENSO recharge oscillator model, find that SPB much weakened when IO coupled with ENSO. To gauge relative role dipole (IOD) and Basin (IOB) modes in weakening ENSO SPB, develop an empirical dynamical linear inverse model (LIM). By coupling/decoupling IOB or IOD mode ENSO, show...
Natural killer-like B (NKB) cells are a newly identified immune subset, which separated from NK and cells. NKB demonstrated immunoregulatory functions in elimination of microbial infection inflammation through secretion interleukin (IL)-12 IL-18. However, the role hepatitis virus (HBV)-related diseases has not been reported. In this study, peripheral T cells, HBV-associated acute-on-chronic liver failure (ACLF), chronic (CHB), asymptomatic HBV carriers (AsC), controls were investigated by...
Abstract We examined the Indian Ocean Dipole (IOD)'s predictive ability for El Niño‐Southern Oscillation (ENSO). Our findings indicate that positive IODs have a stronger impact on subsequent year's ENSO compared to negative IODs. To explain this asymmetry, we proposed “IOD‐Atlantic‐Pacific” pathway, which involves Atlantic in boreal winter as an intermediary. The pathway comprises two stages: (a) asymmetric “IOD‐Atlantic” connection, where autumn trigger Niño while cannot Niña. This...
Abstract Objective This study assessed the outcomes of elderly patients with limited‐stage small cell lung cancer (LS‐SCLC), which may be linked to timing thoracic radiotherapy (TRT) following chemotherapy. Methods Elderly ( n = 78) LS‐SCLC were divided into three groups depending on radiotherapy. The in TRT group stratified early (TRT after 1–2 cycles chemotherapy, 29), medium‐term 3–4 33), and late 5–6 16) groups. overall survival (OS) progression‐free (PFS) compared. Results demonstrated...
Background: A broad-spectrum anti-SARS-CoV-2 monoclonal antibody (mAb), SA55, is highly effective against SARS-CoV-2 variants. This trial aimed at demonstrating the safety, tolerability, local drug retention and neutralizing activity, systemic exposure level, immunogenicity of SA55 nasal spray in healthy individuals. Methods: phase I, dose-escalation clinical combined an open-label design with a randomized, controlled, double-blind design. Healthy participants aged 18–65 years were enrolled...
Abstract Background Multiple vaccines against SARS-CoV-2 have been evaluated in clinical trials, but very few include the pediatric population. The inactivated vaccine CoronaVac ® has shown to be safe and immunogenic a phase 1/2 trial cohort China. This study is an interim safety immunogenicity report of 3 for healthy children adolescents Chile. Methods Participants aged 17 years old received two doses four-week interval. Local systemic adverse reactions were registered 699 participants that...
Previous phase I to III clinical trials have shown that the inactivated SARS-CoV-2 vaccine namely CoronaVac has good efficacy, safety, and immunogenicity. This IV trial aims evaluate lot-to-lot consistency, immunogenicity, safety on a commercial scale in healthy adults, which could provide data support stable manufacturing. In this single-center, randomized, double-blind study, 1,080 adults aged 26-45 years were randomly assigned into three groups receive one of lots vaccines. All subjects...
Machine learning methods have recently achieved high-performance in biomedical text analysis. However, a major bottleneck the widespread application of these is obtaining required large amounts annotated training data, which resource intensive and time consuming. Recent progress self-supervised has shown promise leveraging corpora without explicit annotations. In this work, we built contextual language representation model using BERT, deep bidirectional transformer architecture, to identify...
Background: Safe and effective vaccines against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) are urgently needed to halt the spread of disease 2019 (COVID-19) pandemic. As a promising inactivated SARS-CoV-2 vaccine, CoronaVac (developed by Sinovac Life Sciences, Beijing, China) is currently undergoing its clinical trials in several countries showing good results. We investigated immune mechanisms underlying from perspective single-cell gene expressions function...
The Sinovac enterovirus 71 (EV71) vaccine has been given to children aged 6-35 months with good safety, immunogenicity, and efficacy. Further exploration is needed for the application of EV71 in older children.A phase III, double-blind, single-center, randomized, controlled, non-inferiority, bridging-designed trial enrolled 300 participants 600 36-71 months. Non-inferiority superiority analyses were made determine immunogenicity (Older-S group), comparing that control same age group (Older-C...
Old community renovation is an important project about the livelihood of people, and nation catching work. This paper firstly analyzes definition livable condition old renovation, establishing index system evaluation model renovation. The employs Analytic Hierarchy Process to determine weighs takes use Fuzzy Comprehensive Evaluation Method analyze case.
Chronic hepatitis B (CHB) infection affects approximately 90 million people in China, where there are profoundly unmet clinical and public health needs. This study evaluated patient demographics, disease progression, treatment management using national administrative claims data. retrospective, observational used anonymized data from the China Health Insurance Research Association database (January 1-December 31, 2016); that could not be validated, or duplicate entries, were excluded....
Background Vaccine effectiveness against SARS-CoV-2 infection has been somewhat limited due to the widespread dissemination of Omicron variant, its subvariants, and immune response dynamics naturally infected with virus. Methods Twelve subjects between 3-17 years old (yo), vaccinated two doses CoronaVac ® , were followed diagnosed as breakthrough cases starting 14 days after receiving second dose. Total IgGs different proteins neutralizing capacity these antibodies measured in plasma. The...
Safe and effective vaccines against COVID-19 for children adolescents are needed. This international multicenter, randomized, double-blind, placebo-controlled, phase III clinical trial assessed the efficacy, immunogenicity, safety of CoronaVac® in (NCT04992260). The study was carried out Chile, South Africa, Malaysia, Philippines. enrollment ran from September 10, 2021 to March 25, 2022. For efficacy assessment, median follow-up duration 14 days after second dose 169 days. A total 11,349...