A5010323667- HIV Research and Treatment
- HIV/AIDS drug development and treatment
- SARS-CoV-2 and COVID-19 Research
- COVID-19 Clinical Research Studies
- Monoclonal and Polyclonal Antibodies Research
- Complement system in diseases
- Renal Transplantation Outcomes and Treatments
- Olfactory and Sensory Function Studies
- Herpesvirus Infections and Treatments
- Long-Term Effects of COVID-19
- Alcohol Consumption and Health Effects
- Liver Disease Diagnosis and Treatment
- Neonatal and Maternal Infections
- Parvovirus B19 Infection Studies
- Hepatitis C virus research
- Pneumonia and Respiratory Infections
- RNA Interference and Gene Delivery
- Streptococcal Infections and Treatments
- Cytomegalovirus and herpesvirus research
- Diabetes and associated disorders
- Immune Cell Function and Interaction
- Peripheral Neuropathies and Disorders
- Chemokine receptors and signaling
- Galectins and Cancer Biology
- Sinusitis and nasal conditions
Université Libre de Bruxelles
2021-2025
University of Liverpool
2024
Jawaharlal Nehru Centre for Advanced Scientific Research
2012-2018
SARS-CoV-2 infection in children is less severe than it adults. We perform a longitudinal analysis of the early innate responses and adults with mild within household clusters. Children display fewer symptoms do, despite similar initial viral load, mount robust anti-viral immune signature typical characterized by interferon gene responses; increases cytokines, such as CXCL10 GM-CSF; changes blood cell numbers. When compared adults, antiviral response resolves faster (within week symptoms),...
We demonstrate that at least three different promoter variant strains of HIV-1 subtype C have been gradually expanding and replacing the standard viruses in India, possibly South Africa other global regions, over past decade. The new viral contain an additional NF-κB, NF-κB-like, or RBEIII site promoter. Although acquisition is a property shared by all subtypes, acquiring NF-κB remains exclusive C. acquired κB genetically distinct, binds p50-p65 heterodimer, strengthens levels transcription...
The aim was to evaluate potential predictive factors of smell recovery in a clinical series 288 patients presenting olfactory dysfunction (OD) related coronavirus disease 2019 (COVID-19). Potential correlations were sought between epidemiological, and immunological characteristics the persistence OD at 60 days.COVID-19 positive prospectively recruited from three European hospitals. Baseline evaluations performed within first 2 weeks after onset repeated 30 days. In subgroup patients,...
Antibody-mediated rejection (AMR) is the leading cause of graft failure. While donor-specific antibodies (DSAs) are associated with a higher risk AMR, not all patients DSAs develop rejection, suggesting that characteristics alloantibodies determining their pathogenicity remain undefined. Using human leukocyte antigen (HLA)-A2-specific as model, we apply systems serology tools to investigate qualitative features immunoglobulin G (IgG) including Fc-glycosylation patterns and FcγR-binding...
Abstract Background Human immunodeficiency virus (HIV) infection during pregnancy is associated with reduced transplacental transfer of maternal antibodies and increased risk severe infections in children who are exposed uninfected HIV. The basis this immunity has not yet been defined but could involve modifications the biophysical features antibodies. objective study was to assess impact HIV on serum IgG antibody transfer. Methods Maternal subclass levels, Fc glycosylation, receptor (FcR)...
Background. Most humans have been infected by Cytomegalovirus (CMV) the time they reach forty years of age. Whereas most these CMV infections are well controlled immune system, congenital infection can lead to serious health effects and death for fetus neonate. bywith cytomegalovirus mid-life without clinical signs disease. However, in settings which system is undeveloped or compromised, virus not adequately controlled, consequently presents a major infectious cause both disease during...
Abstract Background The basis of the less severe clinical presentation coronavirus disease 2019 (COVID-19) in children as compared with adults remains incompletely understood. Studies have suggested that a more potent boosting immunity to endemic common cold coronaviruses (HCoVs) may protect children. Methods To test this hypothesis, we conducted detailed analysis antibodies induced by acute respiratory syndrome 2 (SARS-CoV-2) infection aged months 14 years. Results Younger had higher titers...
HIV-1 subtype C (HIV-1C) may duplicate longer amino acid stretches in the p6 Gag protein, leading to creation of an additional Pro-Thr/Ser-Ala-Pro (PTAP) motif necessary for viral packaging. However, biological significance a duplication PTAP replication and pathogenesis has not been experimentally validated. In longitudinal study two different clinical cohorts select seropositive, drug-naive individuals from India, we found that 8 50 these harbored mixed infection strains discordant...
Abstract Olfactory dysfunction (OD) was one of the most common symptom infection with Wuhan strain severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) and could persist for several months after onset. The pathogenesis prolonged OD remains poorly understood but probably involves sustained viral replication associated limited mucosal immune response to virus. This prospective study conducted investigate potential relationship between nasal SARS‐CoV‐2 load antibody levels in patients...
HIV-1 subtype C demonstrates several biological properties distinct from other viral subtypes. One such variation is the duplication of PTAP motif in p6 Gag. a key player budding. Here, we studied prevalence strains longitudinal study.In prospective follow-up study, 65 seropositive drug-naive subjects were monitored two different clinical cohorts India for 2 years with repeated sampling at 6-month intervals. The RNA was extracted plasma, gag segment amplified and sequenced. From subset...
IntroductionComorbidities and immunosuppressive therapies are associated with reduced immune responses to primary COVID-19 mRNA vaccination in kidney transplant recipients (KTRs). In healthy individuals, prior SARS-COV-2 infection is increased vaccine responses, a phenotype called hybrid immunity. this study, we explored the potential influence of suppression on immunity KTRs.MethodsEighty-two KTRs, including 59 SARS-CoV-2-naive 23 SARS-CoV-2-experienced patients, were prospectively studied...
Using several HIV-1 tat exon 1 amino acid sequences available from public databases and additional derived a southern Indian clinical cohort, we compared the profile of signature residues (SAR) between two different time periods, 1986–2004 2005–2014. The analysis identified eight positions as in subtype C Tat demonstrated changing pattern at four these periods. At three locations (histidine 29, serine 57, proline 60), there appears to be nonuniform negative selection against SAR. severe,...
Background: Significant disparities in Group B Streptococcus (GBS) colonisation and neonatal disease rates are documented among high-, middle-, low-income countries, with Bangladesh reporting notably lower than the United Kingdom (UK) Malawi. This study investigates whether this epidemiological variability correlates immune response to GBS these regions.Methods: Qualitative quantitative analysis of naturally acquired immunoglobulin G (IgG) antibodies against capsular polysaccharides (CPS)...
Abstract Most humans have been infected by Cytomegalovirus (CMV) the time they reach forty years of age. Whereas most these CMV infections are well controlled immune system, congenital infection can lead to serious health effects and death for fetus neonate. With clear evidence that risk is lower during chronic maternal infection, varies in association with gestational age at primary further research on humoral responses pregnancy needed. Here, systems serology tools were applied...
Significant disparities in group B Streptococcus (GBS) colonization and neonatal disease rates have been documented across different geographic regions. For example, Bangladesh reports notably lower as compared with the United Kingdom Malawi. This study investigates whether this epidemiologic variability correlates immune response to GBS these Qualitative quantitative analyses of naturally acquired immunoglobulin G (IgG) antibodies against capsular polysaccharide Alp protein family were...
Summary Antibody-mediated rejection (AMR) is the leading cause of graft failure. While donor-specific antibodies (DSA) are associated with a higher risk AMR, not all patients DSA develop suggesting that characteristics alloantibodies determine their pathogenicity remain undefined. Using human leukocyte antigen (HLA)-A2-specific as model, we applied systems serology tools to investigate qualitative features immunoglobulin G (IgG) including Fc-glycosylation patterns and Fc γ R binding...
Methods In a prospective study, cohort of select seropositive drug naive subjects is being monitored at YRG CARE, Chennai for period two years with repeated sampling 6-month intervals. The viral RNA was extracted from plasma and Gag amplified, followed by Sanger sequencing. samples interest were further subjected to next-generation sequencing using Illumina MiSeq analyzed the CLC Genomics Workbench software.