A5026350434- Bacterial Infections and Vaccines
- SARS-CoV-2 and COVID-19 Research
- COVID-19 Clinical Research Studies
- Pneumonia and Respiratory Infections
- Olfactory and Sensory Function Studies
- Long-Term Effects of COVID-19
- Complement system in diseases
- Infectious Encephalopathies and Encephalitis
- Kawasaki Disease and Coronary Complications
- Diabetes and associated disorders
- Alcohol Consumption and Health Effects
- Liver Disease Diagnosis and Treatment
- Peripheral Neuropathies and Disorders
- Respiratory viral infections research
- Infective Endocarditis Diagnosis and Management
- COVID-19 Impact on Reproduction
- Virology and Viral Diseases
- Cardiovascular Function and Risk Factors
- Influenza Virus Research Studies
- Viral Infections and Immunology Research
- Pulmonary Hypertension Research and Treatments
- Immune Response and Inflammation
- Monoclonal and Polyclonal Antibodies Research
- Sinusitis and nasal conditions
- Allergic Rhinitis and Sensitization
University of Geneva
2024
Université Libre de Bruxelles
2021-2024
University Hospital of Geneva
2024
Institut Pasteur de Lille
2018-2021
Center for Infection and Immunity of Lille
2018-2021
Inserm
2018-2021
Université de Lille
2018-2021
Centre National de la Recherche Scientifique
2018-2021
Centre Hospitalier Universitaire de Lille
2018-2021
SARS-CoV-2 infection in children is less severe than it adults. We perform a longitudinal analysis of the early innate responses and adults with mild within household clusters. Children display fewer symptoms do, despite similar initial viral load, mount robust anti-viral immune signature typical characterized by interferon gene responses; increases cytokines, such as CXCL10 GM-CSF; changes blood cell numbers. When compared adults, antiviral response resolves faster (within week symptoms),...
Abstract Background The blunting effect of pertussis immunization during pregnancy on infant antibody responses induced by whole-cell (wP) vaccination is not well-defined. Methods This randomized controlled trial (NCT02408926) followed term infants born to mothers vaccinated with tetanus, diphtheria, and acellular (Tdap) vaccine in Thailand. Infants received either (aP)- or wP-containing at 2, 4, 6, 18 months age. A comparison group comprised wP-vaccinated children pregnancy. Antibodies...
Abstract Pertussis has made a spectacular rebound in countries that have switched from whole-cell (wPV) to acellular pertussis vaccines (aPV). Here, we show that, unlike wPV, aPV, while protective against lung colonization by Bordetella (Bp), did not protect BALB/c mice nasal colonization, but instead substantially prolonged carriage. aPV prevented the natural induction of interleukin-17 (IL-17)-producing and interferon-γ (IFN-γ)-producing CD103 + CD44 CD69 CD4 -resident memory T (T RM )...
The aim was to evaluate potential predictive factors of smell recovery in a clinical series 288 patients presenting olfactory dysfunction (OD) related coronavirus disease 2019 (COVID-19). Potential correlations were sought between epidemiological, and immunological characteristics the persistence OD at 60 days.COVID-19 positive prospectively recruited from three European hospitals. Baseline evaluations performed within first 2 weeks after onset repeated 30 days. In subgroup patients,...
Objectives To comprehensively analyze the quality of antibody response between children with Multisystem inflammatory syndrome (MIS-C) and age-matched controls at one month after SARS-CoV-2 exposure, infected in same time-period. Methods Serum from 20 MIS-C admission, 14 control were analyzed. Antigen specific isotypes subclasses directed against various antigens as well human common coronavirus (HCoVs) commensal or pathogenic microorganisms assessed by a bead-based multiplexed serological...
Pulmonary hypertension and right ventricular (RV) dysfunction are major prognostic determinants in patients with heart failure preserved ejection fraction (HFpEF). The underlying pathomechanisms remain unknown. In this context, we sought to study the pathogenesis of pulmonary RV a rat model obesity-associated HFpEF.
Background Tetanus, diphtheria, acellular pertussis (Tdap) vaccination is recommended to be administered in every pregnancy. Although the safety of this strategy has been confirmed, immunogenicity Tdap two successive pregnancies not yet described. This study investigated Tdap-specific immunity levels and transplacental transfer after repeated Tdap-vaccination. Methods Women enrolled prior studies on during pregnancy were invited participate a follow-up if they became pregnant again. who...
Abstract Background The basis of the less severe clinical presentation coronavirus disease 2019 (COVID-19) in children as compared with adults remains incompletely understood. Studies have suggested that a more potent boosting immunity to endemic common cold coronaviruses (HCoVs) may protect children. Methods To test this hypothesis, we conducted detailed analysis antibodies induced by acute respiratory syndrome 2 (SARS-CoV-2) infection aged months 14 years. Results Younger had higher titers...
Abstract Olfactory dysfunction (OD) was one of the most common symptom infection with Wuhan strain severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) and could persist for several months after onset. The pathogenesis prolonged OD remains poorly understood but probably involves sustained viral replication associated limited mucosal immune response to virus. This prospective study conducted investigate potential relationship between nasal SARS‐CoV‐2 load antibody levels in patients...
To the Editors: In spring of 2020, most children presented with an asymptomatic or pauci-symptomatic infection to SARS-CoV-2,1 while a subset developed multisystem inflammatory syndrome (MIS-C). The physiopathology MIS-C has been widely studied, but exact cause leading development in some is still unclear. We have shown previously that 1-month postinfection, neutralizing activity circulating antibodies and level serum IgA against SARS-CoV-2 were higher patients compared uncomplicated...
IntroductionComorbidities and immunosuppressive therapies are associated with reduced immune responses to primary COVID-19 mRNA vaccination in kidney transplant recipients (KTRs). In healthy individuals, prior SARS-COV-2 infection is increased vaccine responses, a phenotype called hybrid immunity. this study, we explored the potential influence of suppression on immunity KTRs.MethodsEighty-two KTRs, including 59 SARS-CoV-2-naive 23 SARS-CoV-2-experienced patients, were prospectively studied...
Bordetella pertussis, the main causative agent of whooping cough, is a reemerging pathogen, and recent vaccine-resistant strain outbreaks emergence macrolides-resistant strains in China raised new concerns for control disease. New vaccines potentially antibiotics are thus needed. B. pertussis tedious to culture requires several days growth count isolated colonies on agar-based media, making large-scale screening anti-B. compounds or functional evaluation large sample sizes immune sera...
Olfactory dysfunction was one of the most common symptom infection with Wuhan strain SARS-CoV-2 and could persist for several months after onset. The pathogenesis prolonged olfactory (OD) remains poorly understood but probably involves sustained viral replication associated limited mucosal immune response to virus. This prospective study conducted investigate potential relationship between nasal load antibody levels in patients loss smell. One hundred five were recruited 2 weeks presenting...