A5088482885- Chronic Kidney Disease and Diabetes
- Renal Diseases and Glomerulopathies
- Dialysis and Renal Disease Management
- Liver Disease Diagnosis and Treatment
- Sepsis Diagnosis and Treatment
- Chronic Disease Management Strategies
- Healthcare cost, quality, practices
- Pneumocystis jirovecii pneumonia detection and treatment
- Alcohol Consumption and Health Effects
- COVID-19 and healthcare impacts
- Nutrition and Health in Aging
- Diversity and Career in Medicine
- Renal cell carcinoma treatment
- Renal and Vascular Pathologies
- Blood Pressure and Hypertension Studies
- Folate and B Vitamins Research
- COVID-19 Clinical Research Studies
- Pancreatitis Pathology and Treatment
- Tuberculosis Research and Epidemiology
- Central Venous Catheters and Hemodialysis
- Emergency and Acute Care Studies
- Metabolomics and Mass Spectrometry Studies
- Health and Well-being Studies
- HIV/AIDS drug development and treatment
- Vascular Procedures and Complications
Norwegian University of Science and Technology
2016-2025
St Olav's University Hospital
2011-2025
Creative Commons
2023
The University of Texas Health Science Center at San Antonio
2023
SINTEF
2011
Abstract Background Biobanks that hold blood, urine and kidney tissue are key for translational nephrology research but few have limited availability. We describe the organization, baseline characteristics, generalizability of a low-cost national biobank. Materials methods Eight Norwegian hospitals participated in this multi-center, prospective cohort study biobank initiative. Patients referred routine clinical native biopsies were eligible inclusion, starting September 2020. Extensive...
Background: Chronic kidney disease (CKD) is a growing global public health issue. Physical exercise mitigates several kidney-related pathophysiological pathways, yet its impact on function remains underexplored. We investigated the dose-response effect of physical preservation in older adults. Methods: Post-hoc analysis Generation 100 Study, 5-year open-label, randomized, parallel-arm clinical trial conducted from 2012 to 2018 Trondheim, Norway. All inhabitants aged 70-77 years were invited...
Hypertensive nephrosclerosis is among the leading causes of end-stage renal disease, but its pathophysiology poorly understood. We wanted to explore early metabolic changes using gene expression and targeted metabolomics analysis.We analyzed in kidneys biopsied from 20 patients with 31 healthy controls an Affymetrix array. Thirty-one amino acids were measured by liquid chromatography coupled mass spectrometry (LC-MS) urine samples 62 clinical hypertensive 33 age- sex-matched controls, major...
Hypertensive nephrosclerosis is considered the second most common cause of end-stage renal disease (ESRD), but it still an insufficiently studied and controversial entity. More information on phenotype prognosis needed to improve clinical diagnostics treatment.We included all Norwegian patients with chronic kidney (CKD) referred for biopsy between 1988 2012 whose presentation was consistent with, not primarily suspicious for, hypertensive (n = 4920); follow-up continued until 2013.A total...
Key Points The pathophysiological mechanisms of diabetic kidney disease (DKD) with normal (nonalbuminuric DKD) versus moderately increased albuminuria (A-DKD) are not well-understood. Fatty acid biosynthesis and oxydation, gluconeogenesis, TCA cycle, glucose-alanine cycle were more disturbed in patients A-DKD compared those nonalbuminuric DKD identical eGFR. without microalbuminuria could represent different clinical phenotypes. Background [NA-DKD] A-DKD) currently well-understood have...
Objective: Hypertensive nephropathy (HN) represents a major cause of chronic kidney disease, but it is incompletely understood why some patients show disease progression. Our project aim to identify potential markers progression and novel therapeutic targets. Design method: Adult (n=43; n=16 females, mean age 53 years) with biopsy-verified HN were categorized as ’early’ (estimated glomerular filtration rate (eGFR) >45 ml/min/1.73m2) or ’late’ (eGFR <45 at the time biopsy. Patients...
Abstract Background and Aims Hypertensive nephropathy (HN) is a significant contributor to chronic kidney disease, yet the factors influencing disease progression remains elusive. Notably, late-stage significantly impacts patient outcome. This project aims unveil novel therapeutic targets for of HN using transcriptomic approach. Method A cohort adult patients (n = 21; n 9 females, mean age 57 years) with biopsy-confirmed were selected from Norwegian Kidney Biopsy Registry (NKBR). Patients...
Abstract Background Patients on kidney replacement therapy (KRT) are at very high risk of coronavirus disease 2019 (COVID-19). The triage pathway for KRT patients presenting to hospitals with varying severity COVID-19 illness remains ill-defined. We studied the clinical characteristics initial and subsequent hospital presentations impact patient outcomes. Methods European Renal Association Database (ERACODA) was analysed laboratory features 1423 either hospitalized or non-hospitalized those...
NOE Å LAERE AVNoe å laere av En ung kvinne med nyresvikt1 i 30-årene ble innlagt uttalt anemi etter 14 dager
Abstract Background and Aims Patients on kidney replacement therapy (KRT) are at high risk of developing severe COVID-19 illness often require intensity care utilisation hospital resources. During the ongoing pandemic, optimal pathway triage for KRT patients presenting with varying severity is unknown. We studied clinical factors outcomes associated admission, readmission short-term outcomes. Method Data from European Renal Association Database (ERACODA) was analysed. This database includes...