A5103147088- Neuroscience and Neuropharmacology Research
- Neural dynamics and brain function
- Neuroscience and Neural Engineering
- Transcranial Magnetic Stimulation Studies
- Photoreceptor and optogenetics research
- Memory and Neural Mechanisms
- Neurological disorders and treatments
- Receptor Mechanisms and Signaling
- Atmospheric and Environmental Gas Dynamics
- Carbon Dioxide Capture Technologies
- Neurogenesis and neuroplasticity mechanisms
- Photochromic and Fluorescence Chemistry
- Neuroscience of respiration and sleep
- Nuclear Receptors and Signaling
- Neuroinflammation and Neurodegeneration Mechanisms
- Neuropeptides and Animal Physiology
- Atmospheric chemistry and aerosols
RIKEN Center for Brain Science
2013-2020
Nippon Soken (Japan)
2017
RIKEN
2017
Osaka University
2009-2013
Abstract Transcranical direct current stimulation (tDCS) is a treatment known to ameliorate various neurological conditions and enhance memory cognition in humans. tDCS has gained traction for its potential therapeutic value; however, little about mechanism of action. Using transgenic mouse expressing G-CaMP7 astrocytes subpopulation excitatory neurons, we find that induces large-amplitude astrocytic Ca 2+ surges across the entire cortex with no obvious changes local field potential....
Abstract Astrocytes may function as mediators of the impact noradrenaline on neuronal function. Activation glial α1-adrenergic receptors triggers rapid astrocytic Ca 2+ elevation and facilitates synaptic plasticity, while activation β-adrenergic elevates cAMP levels modulates memory consolidation. However, dynamics these processes in behaving mice remain unexplored, do interactions between distinct second messenger pathways. Here we simultaneously monitored demonstrate that messengers are...
In the brain, glycogen metabolism has been implied in synaptic plasticity and learning, yet distribution of this molecule not fully described. We investigated cerebral mouse by immunohistochemistry (IHC) using two monoclonal antibodies that have different affinities depending on size. The use focused microwave irradiation yielded well‐defined immunoreactive signals compared with conventional periodic acid‐Schiff method. IHC displayed a punctate localized predominantly astrocytic processes....
We report that a brief electrical stimulation of the nucleus basalis Meynert (NBM), primary source cholinergic projection to cerebral cortex, induces biphasic cortical blood flow (CBF) response in somatosensory cortex C57BL/6J mice. This CBF response, measured by laser Doppler flowmetry, was attenuated muscarinic type acetylcholine receptor antagonist atropine, suggesting possible involvement astrocytes this modulation. However, we find IP3R2 knockout mice, which lack cytosolic Ca2+ surges...
Transcranial direct current stimulation (tDCS) has been reported for its beneficial effects on memory formation and various brain disorders. While the electrophysiological readout of tDCS is subtle, astrocytes have demonstrated to elicit Ca 2+ elevations during in a rodent model. This study aimed elucidate another major glial cell type, microglia, by histology vivo imaging. performed awake conditions induced significant change pixel intensity distribution Iba-1 immunohistochemistry,...
Not only from our daily experience but learning experiments in animals, we know that the establishment of long-lasting memory requires repeated practice. However, cellular backgrounds underlying this repetition-dependent consolidation remain largely unclear. We reported previously using organotypic slice cultures rodent hippocampus inductions LTP (long-term potentiation) lead to a slowly developing synaptic enhancement accompanied by synaptogenesis distinct itself and proposed phenomenon as...
Abstract Long‐term potentiation (LTP) in the rodent hippocampus is a popular model for synaptic plasticity, which considered cellular basis brain memory. Because most LTP analysis involves acutely prepared slices, however, longevity of single has not been well documented. Using stable hippocampal slice cultures long‐term examination, we previously found that disappeared within 1 day. In contrast, repeated induction led to development distinct type plasticity lasted more than 3 weeks and was...