A5089904607- Neonatal Respiratory Health Research
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Pulmonary Hypertension Research and Treatments
- Congenital Diaphragmatic Hernia Studies
- Silicon Carbide Semiconductor Technologies
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Respiratory viral infections research
- Birth, Development, and Health
- Pregnancy and preeclampsia studies
- Extracellular vesicles in disease
- Gestational Diabetes Research and Management
- Influenza Virus Research Studies
- Tissue Engineering and Regenerative Medicine
- Medical Imaging and Pathology Studies
- Semiconductor materials and interfaces
- Copper Interconnects and Reliability
- Congenital Heart Disease Studies
- Kawasaki Disease and Coronary Complications
- Child Nutrition and Feeding Issues
- Aluminum Alloys Composites Properties
- Advanced ceramic materials synthesis
- Congenital Anomalies and Fetal Surgery
- Silicon and Solar Cell Technologies
- Infectious Encephalopathies and Encephalitis
- Smoking Behavior and Cessation
Tohoku University
2015-2025
Tohoku University Hospital
2019-2024
National Livestock Breeding Center
2024
Toshiba (Japan)
2019-2023
Kyoto University
2023
Tokai Gakuen University
2022
Ministry of Education, Culture, Sports, Science and Technology
2022
National Institute for Environmental Studies
2022
Ministry of Health Labour and Welfare
2022
Community Link
2022
Idiopathic pulmonary fibrosis (IPF) is a devastating lung disease with poor prognosis and limited therapeutic options. The incidence of IPF increases age, ageing-related mechanisms such as cellular senescence have been proposed pathogenic drivers. alveolar epithelium represents major site tissue injury in this cell population probably detrimental to repair. However, the potential pathomechanisms epithelial impact senolytic drugs on senescent cells remain unknown. Here we demonstrate that...
Abstract Recent advances in 3D bioprinting allow for generating intricate structures with dimensions relevant human tissue, but suitable bioinks producing translationally tissue complex geometries remain unidentified. Here, a tissue‐specific hybrid bioink is described, composed of natural polymer, alginate, reinforced extracellular matrix derived from decellularized (rECM). rECM has rheological and gelation properties beneficial while retaining biologically inductive supporting maturation ex...
<h3>Rationale</h3> The influence of COPD exacerbation on the endothelium is not completely understood. Circulating endothelial microparticles (EMPs) are membrane vesicles in circulating blood that shed by activated or apoptotic cells. <h3>Objective</h3> To compare EMP numbers stable patients with those during and after exacerbation. <h3>Methods</h3> We examined 80 patients, 27 exacerbated COPD, 20 healthy non-COPD volunteers. EMPs were defined as CD144+ MPs (VE-cadherin EMPs), CD31+/CD41−...
Idiopathic pulmonary fibrosis (IPF) is a disease with poor prognosis. Although the median survival 3 years, clinical course varies to large extent among IPF patients. To date, there has been no definitive prognostic marker. Extracellular vesicles (EVs) are known hold nucleic acid, including microRNAs, and regulate gene expression in recipient cells. Moreover, EVs have shown express distinct surface proteins or enveloped microRNAs depending on parent cell pathological condition. We aimed...
Idiopathic pulmonary fibrosis (IPF) is a fatal interstitial lung disease. Repetitive injury and reprogramming of the epithelium are thought to be critical drivers disease progression, contributing fibroblast activation, extracellular matrix remodeling, subsequently loss architecture function. To date, Pirfenidone Nintedanib only approved drugs known decelerate however, if how these affect epithelial cell function, remains largely unexplored.We treated murine human 3D ex vivo tissue cultures...
Abstract Background The excess and persistent accumulation of fibroblasts due to aberrant tissue repair results in fibrotic diseases such as idiopathic pulmonary fibrosis. Recent reports have revealed significant changes microRNAs during fibrosis evidence support a role for myofibroblast differentiation the epithelial-mesenchymal transition context It has been reported that microRNA-21 is up-regulated myofibroblasts promotes transforming growth factor-beta signaling by inhibiting Smad7....
ABSTRACT Aims This study investigated the association between maternal age and early late gestational diabetes mellitus (GDM). Methods In total, 72,270 pregnant women were included in this prospective birth cohort study. Associations GDM (diagnosed at <24 weeks) ≥24 evaluated using a multinomial logistic regression model with possible confounding factors. The reference category was of 30–34.9 years. Results Higher associated higher odds ( P ‐value for trend <0.0001 <0.0001,...
Abstract Wnt/β-catenin signaling regulates progenitor cell fate decisions during lung development and in various adult tissues. Ectopic activation of promotes tissue repair emphysema, a devastating disease with progressive loss parenchymal tissue. The identity responsive cells the potential impact on distal epithelial function emphysema are poorly understood. Here, we used TCF/Lef:H2B/GFP reporter mice to investigate role organoid formation. We identified an organoid-forming population...
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ABSTRACT Aims This study aimed to investigate the association of maternal birth weight (MBW) with early and late gestational diabetes mellitus (GDM). Methods A total 69318 pregnant Japanese women were included in this cohort study. The associations between (diagnosed at <24 weeks) GDM ≥24 investigated using a multinomial logistic regression model, an 3000–3499 g as reference category. Results Lower was associated higher odds developing ( P < 0.0001 0.0001, respectively). adjusted...
Background/Objectives: Malocclusion in primary dentition affects permanent dentition. However, the factors contributing to malocclusion oral cavities of children have not been fully elucidated. We hypothesized that environmental affect Japanese population and aimed identify associated with anterior occlusion Methods: The study involved 3793 parent-child pairs from Miyagi Regional Centre as part a supplementary survey Japan Environment Children's Study, cohort study. A questionnaire assessing...
Previous studies have demonstrated that paternal involvement in childcare for infants up to 6 months of age can prevent injuries children 18 age. However, the relationship after has not been clearly established. Therefore, this study investigated association between at and birth 4 years This analysed data from 72,343 mothers who participated Japan Environment Children's Study (JECS). Seven items age—indoor play, outdoor feeding child, diaper changing, dressing, bathing, putting child...
This study aimed to investigate the association and population-attributable fraction (PAF) of maternal smoking secondhand smoke (SHS) exposure during pregnancy with placental abruption. Prospective cohort study. 15 regional centres in Japan. Pregnant women registered between January 2011 March 2014 from Japan Environment Children's Study. Data were transcribed medical records two self-administered questionnaires. The outcome measure was incidence Maternal categorised based on number...
Functional constipation is the most common gastrointestinal disorder during childhood. Oral stimulation (mastication and toothbrushing) reportedly improves bowel movements, but association between daily toothbrushing behavior functional remains unknown. Data (n = 83,660) from fetal records 104,059) in Japan Environment Children's Study, an ongoing prospective birth cohort, were analyzed to investigate impact of frequency on childhood, using ROME III diagnostic criteria. After multiple...
Abstract Obesity during development has been reported to be a determinant factor in the future of non-communicable diseases (NCDs). Parental obesity is suggested predictor children’s obesity, and it important consider parental factors prevent NCDs progeny. Previously, we showed that paternal height had stronger association with infant birth weight than body mass index (BMI) Japanese population. However, only few studies have examined between physique postnatal obesity. This study aimed...
Abstract Few studies have evaluated the association between duration of mothers’ digital media use (including mobile phones, tablets, and PCs) while with their children children’s development. Using data from Japan Environment Children’s Study, we explored this relationship through multiple regression analysis. Self-administered questionnaires measured use. Developmental outcomes were assessed using Kyoto Scale Psychological Development 2001 (KSPD), administered to two-year-olds by trained...
The relationship of pre-pregnancy body mass index (BMI) and gestational weight gain (GWG) with continued breastfeeding (BF) in Japanese women remains unclear. To evaluate different maternal BMI GWG categories according to the initial BMI, we conducted an analysis BF until 6 months postpartum a large cohort. This study used data from Japan Environment Children's Study, which included approximately 100,000 pregnant women. Pre-pregnancy (kg/m2) was categorized as underweight (BMI < 18.5),...
Aim: Surfactant protein-C (SP-C) of alveolar epithelial type II cells (ATII) plays a key role in maintaining integrity and repair. Mutations or decreased expression SFTPC, the gene encoding SP-C, causes ATII injury aberrant repair lung tissue to develop pulmonary fibrosis. Histone deacetylases (HDACs) epigenetically remove acetyl groups from acetylated histones regulate transcription. HDAC inhibitors attenuated epithelial-to-mesenchymal transition (EMT) fibrotic disorders. The aim this study...
Abstract Mechanisms of injury and repair in alveolar epithelial cells (AECs) are critically involved the progression various lung diseases including idiopathic pulmonary fibrosis (IPF). Homeobox only protein x (HOPX) contributes to formation distal during development. In adult lung, type (AT) I express HOPX lineage-labeled Hopx + give rise both ATI ATII after pneumonectomy. However, cell function HOPX-expressing fibrotic has not been investigated. this study, we have established a flow...
Expression of c-Kit and its ligand, stem cell factor (SCF), in developing human lung tissue was investigated by immunohistochemistry. Twenty-eight fetal lungs [age range 13 to 38 gestational wk (GW)] 12 postnatal (age 1-79 yr) were evaluated. We identified c-Kit(+) cells the mesenchyme as early GW. These mesenchymal did not express mast tryptase or α-smooth muscle actin. However, these CD34, VEGFR2, Tie-2, indicating their endothelial lineage. Three-dimensional reconstructions confocal laser...
Objective The changes in the prevalence of acute meningitis during coronavirus disease 2019 (COVID-19) pandemic remain unclear. This study aimed to compare before and COVID-19 Japan. Methods We retrospectively reviewed Japanese nationwide administrative medical payment system database, Diagnosis Procedure Combination (DPC), from 2016 2022. A total 547 hospitals consistently seamlessly offered DPC data this period. period was divided into following three periods: April March 2018 (fiscal...
Excess production of neutrophil elastase contributes to the pathogenesis acute lung injury (ALI) and respiratory distress syndrome (ARDS). However, role in repair process following ALI/ARDS is not well understood. The objective this study was evaluate effect on tissue after mice. C57BL/6 mice were exposed sublethal irradiation followed by intranasal instillation lipopolysaccharide (LPS) generate a model impaired repair. authors assessed histopathology, mechanics, total collagen content 7...