A5030024694- Hippo pathway signaling and YAP/TAZ
- Cell Adhesion Molecules Research
- RNA modifications and cancer
- Cancer-related molecular mechanisms research
- Islamic Thought and Society Studies
- Families in Therapy and Culture
- RNA Research and Splicing
- Turkish Literature and Culture
- Tissue Engineering and Regenerative Medicine
- 3D Printing in Biomedical Research
- Alcohol Consumption and Health Effects
- Endoplasmic Reticulum Stress and Disease
- Metallurgy and Material Forming
- Metal Alloys Wear and Properties
- Induction Heating and Inverter Technology
- Pluripotent Stem Cells Research
- Genetics, Aging, and Longevity in Model Organisms
- Congenital heart defects research
Lund University
2020-2023
University of Jordan
2022
Lund Science (Sweden)
2020
Abstract Recent advances in 3D bioprinting allow for generating intricate structures with dimensions relevant human tissue, but suitable bioinks producing translationally tissue complex geometries remain unidentified. Here, a tissue‐specific hybrid bioink is described, composed of natural polymer, alginate, reinforced extracellular matrix derived from decellularized (rECM). rECM has rheological and gelation properties beneficial while retaining biologically inductive supporting maturation ex...
Inadequate adaption to mechanical forces, including blood pressure, contributes development of arterial aneurysms. Recent studies have pointed a mechanoprotective role YAP and TAZ in vascular smooth muscle cells (SMCs). Here, we identified reduced expression YAP1 human aortic Vascular SMC-specific knockouts (KOs) YAP/TAZ were thus generated using the integrin α8-Cre (Itga8-Cre) mouse model (i8-YT-KO). i8-YT-KO mice spontaneously developed aneurysms abdominal aorta within 2 weeks KO induction...
Hypertension remains a major risk factor for cardiovascular diseases, but the underlying mechanisms are not well understood. We hypothesize that appropriate mechanotransduction and contractile function in vascular smooth muscle cells crucial to maintain wall integrity. The Hippo pathway effectors YAP (yes-associated protein 1) TAZ (WW domain containing transcription regulator have been identified as mechanosensitive transcriptional coactivators. However, their role cell has investigated...
YAP (Yap1) and TAZ (Wwtr1) are transcriptional co-activators downstream effectors of the Hippo pathway, which play crucial roles in organ size control cancer pathogenesis. Genetic deletion YAP/TAZ has shown their critical importance for embryonic development heart, vasculature, gastrointestinal mesenchyme. The aim this study was to determine functional role adult smooth muscle cells vivo. Because mutually redundant, we used double-floxed mice crossed with that express tamoxifen-inducible...
Abstract Smooth muscle cells (SMCs) are characterized by a high degree of phenotypic plasticity. Contractile differentiation is governed myocardin‐related transcription factors (MRTFs), in particular myocardin (MYOCD), and when their drive lost, the become proliferative synthetic with an expanded endoplasmic reticulum (ER). ER responsible for assembly folding secreted proteins. When load on surpasses its capacity, three stress sensors (activating factor 6 [ATF6], inositol‐requiring enzyme 1α...
Smooth muscle cells contribute significantly to lipid-laden foam in atherosclerotic plaques. However, the underlying mechanisms transforming smooth into are poorly understood. The purpose of this study was gain insight molecular regulating cell formation. Using human coronary artery we found that transcriptional co-activator MRTFA promotes lipid accumulation via several mechanisms, including direct control LDL receptor, enhanced fluid-phase pinocytosis and reduced efflux. Inhibition MRTF...
Vascular smooth muscle cell plasticity plays a pivotal role in the pathophysiology of vascular diseases. Despite compelling evidence demonstrating importance transcription factor GATA6 muscle, functional remains poorly understood. The aim this study was to elucidate on migration and gain insight into GATA6-sensitive genes muscle. We found that overexpression promotes human coronary artery cells vitro, silencing resulted reduced cellular motility. Furthermore, complete microarray screen gene...