A5084886088- Trypanosoma species research and implications
- Geology and Paleoclimatology Research
- Research on Leishmaniasis Studies
- Viral Infections and Immunology Research
- Planetary Science and Exploration
- Methane Hydrates and Related Phenomena
- Geological formations and processes
- Galectins and Cancer Biology
- Isotope Analysis in Ecology
- Cardiomyopathy and Myosin Studies
- Pain Mechanisms and Treatments
- Urticaria and Related Conditions
- Streptococcal Infections and Treatments
- Dermatological and COVID-19 studies
- Health, Nursing, Elderly Care
- Business and Management Studies
- Cardiovascular Function and Risk Factors
- Vasculitis and related conditions
- Lysosomal Storage Disorders Research
- Building materials and conservation
- Geological and Geochemical Analysis
- RNA modifications and cancer
- Botulinum Toxin and Related Neurological Disorders
- Healthcare and Venom Research
- Hygrothermal properties of building materials
Universidade de São Paulo
2013-2023
Instituto de Geociencias
2017
Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo
2011
Millennium Institute
2007
Background Chronic Chagas cardiomyopathy (CCC), a life-threatening inflammatory dilated cardiomyopathy, affects 30% of the approximately 8 million patients infected by Trypanosoma cruzi. Even though Th1 T cell-rich myocarditis plays pivotal role in CCC pathogenesis, little is known about factors controlling cell migration to myocardium. Methods and Results Using confocal immunofluorescence quantitative PCR, we studied surface staining gene expression CXCR3, CCR4, CCR5, CCR7, CCR8 receptors...
The pathogenesis of Chagas disease cardiomyopathy (CCC) is not well understood. Since studies show that myocarditis more frequent during the advanced stages disease, and prognosis CCC worse than other dilated cardiomyopathies non-inflammatory aetiology, which suggest inflammatory infiltrate plays a major role in myocardial damage. In last decade, increasing evidence has shown cytokines chemokines play generation tissue patients have an increased peripheral production Th1 IFN-gamma TNF-alpha...
Abstract In the present study, we used electronic version of von Frey test to investigate role cytokines (TNF‐α and IL‐1β) chemokines (KC/CXCL‐1) in genesis mechanical hypernociception during antigen‐induced inflammation mice. The nociceptive consisted evoking a hindpaw flexion reflex with hand‐held force transducer (electronic anesthesiometer) adapted 0.5mm 2 polypropylene tip. intraplantar administration methylated bovine serum albumin (mBSA) previously immunized (IM), but not...
Chronic Chagas disease cardiomyopathy (CCC), a late consequence of Trypanosoma cruzi infection, is an inflammatory with prognosis worse than those noninflammatory etiology (NIC). Although the T cell-rich myocarditis known to play pathogenetic role, relative contribution each functional cell subsets has never been thoroughly investigated. We therefore assessed gene expression cytokines and transcription factors involved in differentiation effector function subset (TH1/TH2/TH17/Treg) CCC, NIC,...
Chagas disease, caused by the protozoan Trypanosoma cruzi is endemic in Latin America. Thirty percent of infected individuals develop chronic cardiomyopathy (CCC), an inflammatory dilated that is, far, most important clinical consequence T. infection. The others remain asymptomatic (ASY). A possible genetic component to disease progression was suggested familial aggregation cases and association markers innate adaptive immunity genes with CCC development. Migration Th1-type T cells play a...
Abstract Human chronic Chagas disease cardiomyopathy (CCC) is an inflammatory‐dilated occurring years after infection by the protozoan Trypanosoma cruzi . The heart inflammatory infiltrate in CCC shows a 2:1 predominance of CD8 + relation to CD4 T cells, with typical Th1‐type cytokine profile. However, vitro expansion infiltrating cells from biopsy‐derived fragments interleukin‐2 (IL‐2) and phytohaemagglutinin leads outgrowth over cells. We hypothesized that survival cytokines, such as IL‐2,...
Rheumatic fever (RF) is an autoimmune disease triggered by Streptococcus pyogenes infection frequently observed in infants from developing countries. heart (RHD), the major sequel of RF, leads to chronic inflammation myocardium and valvular tissue. T cells are main population infiltrating cardiac lesions; however, chemokines that orchestrate their recruitment not clearly defined. Here, we investigated expression chemokine receptors tissue biopsies obtained RHD patients. Our results showed...
AimsChagas disease, caused by the protozoan Trypanosoma cruzi is endemic in Latin America, and may lead to a life-threatening inflammatory dilated, chronic Chagas cardiomyopathy (CCC). One third of T. cruzi-infected individuals progress CCC while others remain asymptomatic (ASY). A possible genetic component disease progression was suggested familial aggregation cases association markers innate adaptive immunity genes with development. Since mutations multiple sarcomeric genes, including...
ABSTRACT: The development of optically stimulated luminescence (OSL) dating sediments has led to considerable advance in the geochronology Quaternary. OSL is a well established technique determine sediment burial ages from tens years few hundred thousand years. Recent studies have shown that Quaternary Brazil are dominated by quartz grains with high sensitivity, allowing determination precise and reliable ages. In this paper, we show examples aliquots single different regions Brazil,...
Salivary gland extracts (SGE) from Lutzomyia longipalpis potentate L. major infection by inducing a Th2 immune response. However, the effect of SGE on effector phase response is not known. Herein, we demonstrate that inhibited neutrophil migration in ovalbumin (OVA)-induced peritonitis immunized mice. pretreatment mice OVA-induced CD4+ and CD8+ T lymphocyte migration. The production TNF-alpha, IL-1beta leukotriene B4 (LTB4), chemotactic mediators this model, were SGE. On other hand, enhanced...
Introdução A Hipertensão Arterial Resistente é definida quando a pressão arterial se mantém acima das metas pressóricas recomendadas mesmo com uso de três fármacos anti-hipertensivos ação sinérgica em dose máxima preconizada e tolerada adesão comprovada, preferencialmente, sendo um deles diuréticos ou aqueles que utilizam quatro mais anti-hipertensivo para controle da arterial. Apresentando uma prevalência torno 10 20% população hipertenso do mundo, porém maior morbimortalidade comparado não...
The Amazonia biome hosts upland closed and open vegetation ecosystems, in which the current biogeographical patterns relate to evolution of physical landscape. Therefore, understanding origin timing substrates supporting different ecosystems is indispensable for better comprehension Amazonian biogeography. Here we used quartz optically stimulated luminescence (OSL) thermally transferred (TT-OSL) dating sandy environments Central Eastern Amazonia, from both outcrop drill core samples (Autazes...
In order to evaluate the suitability of minerals other than quartz and feldspar for luminescence dating sediments, properties from almandine kyanite relevant dosimetry such as signal stability, bleachability by sunlight exposure, dose response are investigated. Thermoluminescence (TL) signals (UV emission) aliquots present athermal instability entire tested TL temperature range (25 – 450 °C). Almandine also presents a significant infrared stimulated (IRSL), post-infrared IRSL (post-IR IRSL)...
A região da foz do rio Itaguaré, localizada no Parque Estadual Restinga de Bertioga-SP, apresenta uma miscelânea processos sedimentares e formas leito atuais gerados pela ação marés, ondas próprio rio. Ocorrem também depósitos quaternários expostos ao longo falésia dezenas metros extensão por até 4m altura, formados análogos aos observados na praia adjacente. Seus são compostos areias finas, moderadamente a bem selecionadas, com estratificação plano-paralela, tendo em sua porção inferior...