A5053793957- Cervical Cancer and HPV Research
- Reproductive System and Pregnancy
- Reproductive Physiology in Livestock
- Reproductive tract infections research
- T-cell and B-cell Immunology
- Retinal Development and Disorders
- Genital Health and Disease
- Cancer-related molecular mechanisms research
- Hepatitis B Virus Studies
- Endometrial and Cervical Cancer Treatments
- Psoriasis: Treatment and Pathogenesis
- Endometriosis Research and Treatment
- T-cell and Retrovirus Studies
- Intracranial Aneurysms: Treatment and Complications
- Immune Cell Function and Interaction
- Immune Response and Inflammation
- Hepatitis C virus research
- Immunotherapy and Immune Responses
- Retinal Diseases and Treatments
- Reproductive Biology and Fertility
- Ectopic Pregnancy Diagnosis and Management
- Childhood Cancer Survivors' Quality of Life
- Cerebrovascular and Carotid Artery Diseases
- Asthma and respiratory diseases
- Colorectal and Anal Carcinomas
Boehringer Ingelheim (China)
2025
Grupo Santa Casa de Belo Horizonte
2009-2024
Boehringer Ingelheim (Germany)
2024
Weatherford College
2023
CASA
2023
Universidade Federal de Minas Gerais
2022
Instituto de Ensino e Pesquisa Santa Casa
2012-2020
Insper
2014-2020
Délégation Paris 7
2012-2016
Sorbonne Paris Cité
2012-2016
// Layale Yaghi 1, 2, 3 , Isabelle Poras 2 Renata T. Simoes 4 Eduardo A. Donadi 5 Jörg Tost 6, 7 Antoine Daunay 6 Bibiana Sgorla de Almeida Edgardo D. Carosella Philippe Moreau 1 Commissariat à l'Energie Atomique et aux Energies Alternatives, Institut des Maladies Emergentes Thérapies Innovantes, Service Recherches en Hémato-Immunologie, Hôpital Saint-Louis, Paris, France Université Paris-Diderot, Sorbonne Paris-Cité, UMR E5, Universitaire d'Hématologie, Lebanese University, School of...
Definite causes for several pathologies of pregnancy remain unknown. In light recent studies, however, diminished or aberrant HLA-G expression may be associated with certain complication and linked to polymorphism. We analyzed DNA from 60 normal placentas (controls), 140 miscarriage, 36 preeclampsia, 76 fetal hypotrophy, 34 hypoxia variations in coding regions (allelic groups G*0101 G*0107) the 14-bp deletion/insertion into 3'-untranslated region. No statistically significant differences...
Human leukocyte antigen-G (HLA-G) is a nonclassical major histocompatibility complex (MHC) class I molecule involved in immune tolerance processes, playing an important role the maintenance of semi-allogeneic fetus. Although HLA-G expression restricted normal tissues, it broadly expressed malignant tumors and may favor tumor escape. We analyzed protein mRNA samples from patients with glioblastoma collected France, Denmark, Brazil. found 65 108 20 21 samples. The absence was associated better...
Generalized pustular psoriasis (GPP) is a heterogeneous, neutrophilic inflammatory disease associated with chronic skin and systemic symptoms, potentially life-threatening flares. We present safety efficacy data from real-world expanded access program (EAP) in China (12 sites; May 2022–July 2023), which provided early to spesolimab (an anti-interleukin-36 receptor antibody) for patients not eligible clinical trials no alternative treatment. Spesolimab was later approved the treatment of GPP...
HLA-G and HLA-E are two nonclassical class I molecules, which have been well recognized as modulators of innate adaptive immune responses, the expression these molecules in virus infected cells has associated with subversion response.In this study we performed a cross-sectional study, systematically comparing benign, pre-malignant malignant laryngeal lesions, correlating demographic clinical variables presence high-risk low-risk HPV types.Laryngeal lesions were collected from 109 patients...
The genetic heterogeneity of Mendelian disorders results in a significant proportion patients that are unable to be assigned confident molecular diagnosis after conventional exon sequencing and variant interpretation. Here, we evaluated how many with an inherited retinal disease (IRD) have variants uncertain significance (VUS) disrupting splicing known IRD gene by means other than affecting the canonical dinucleotide splice site. Three silico splice-affecting predictors were leveraged...
Human leukocyte antigen-G (HLA-G) is a non-classical major histocompatibility complex class Ib molecule that acts as specific immunosuppressor. Some studies have demonstrated human papillomavirus (HPV) seems to be involved in lower or absent HLA-G expression, particularly cervical cancer. In this study, we performed cross-sectional systematically comparing the qualitative expression of HLA-G5 isoform invasive carcinoma (ICC), stratifying patients according presence [ICC with metastasis...
The HLA-G and HLA-E molecules, Ki67, progesterone (PR), estrogen (ER) androgen receptors (AR), p53, COX-2, HER2 were studied to assess whether the biological behavior of grade I meningiomas is related their expression. Tissue samples from 96 patients with intracranial analyzed by immunohistochemistry on tissue microarray blocks (TMA) using antibodies specific for HLA-G, HLA-E, PR, ER, AR, HER2. Meningiomas classified as small (≤2 cm, 1.0%), medium (>2 ≤4 32.3%), large (>4 66.7%). Tumor size...
Abstract HLA‐G (human leukocyte antigen‐G) plays an important role in the modulation of maternal immune system during pregnancy. alleles presenting a 14‐bp insertion at exon 8 have been associated with decreased messenger RNA levels, preeclampsia, and miscarriages. This suggests that natural selection may exert strong influence against allele isolated populations. DNA samples from 384 Amazonian Indians spread across seven tribes were evaluated for polymorphism. The frequency (38.54%) was...
HPV persistence is a key determinant of cervical carcinogenesis. The influence postpartum on clearance has been debated. This study aimed to assess in later pregnancy and among HIV-positive negative women. We conducted follow-up with 151 HPV-positive women coinfected HIV, 2007–2010. After baseline assessment, all were retested for infection using PCR after delivery. Multivariable logistic regressions assessed the putative association covariates status between each one successive visits....
Leber congenital amaurosis (LCA) is a severe disease that leads to complete blindness in children, typically before the first year of life. Due clinical and genetic heterogeneity among LCA other retinal diseases, providing patients with molecular diagnosis essential assigning an accurate diagnosis. Using our gene panel targets 300 genes are known cause disease, including 24 reported LCA, we sequenced 43 unrelated probands Brazilian ancestry. We identified 42 unique variants were able assign...
The larynx is the most common site of malignancy in upper aerodigestive tract. In Brazil, malignant laryngeal lesions represent 2% all cancers, with approximately 3000 annual deaths. association between human papillomavirus (HPV) and cancer still controversial. aim present retrospective study was to determine expression galectin-3 immunoperoxidase carcinoma by examining paraffin-embedded biopsies from 65 patients, 10 situ carcinomas, 27 carcinomas without metastases, 28 metastases....
Objective To determine the frequency of sexually transmitted infections (STIs) in asymptomatic women and association STIs with cervical intraepithelial neoplasia (CIN). Methods A cross-sectional study was performed, enrolling examined a general gynecology clinic colposcopy referral center from October 2014 to 2015. The group consisted 71 women, 55 women. Cervical samples were collected for cytology multiplex real-time polymerase chain reaction (PCR) developed detect human papillomavirus...
We examined whether the allelic and/or genotypic profile of locus -1562C/T matrix metalloproteinase (MMP-9) gene influences protein expression levels MMP-9 in patients with colorectal cancer (CRC) compared controls.A total 104 CRC and 84 controls were evaluated.Peripheral blood was collected from both groups DNA extraction performed for genotyping; plasma used quantification.The CT genotype associated increased (P = 0.0211).High protein, independently polymorphisms, observed patient group <...