CONTEXT AND OBJECTIVE: Previous studies have suggested that the occurrence of pregnancy concomitantly with a diagnosis breast cancer may affect evolution neoplasia. The present study aimed to compare pregnancy-associated (PABC) patients non-pregnant (controls) in relation time taken diagnose disease, tumor characteristics and mortality. DESIGN SETTING: A retrospective, paired case-control was conducted at Hospital da Santa Casa de Misericórdia Centro Quimioterapia Antiblástica e Imunoterapia...

The HLA-G and HLA-E molecules, Ki67, progesterone (PR), estrogen (ER) androgen receptors (AR), p53, COX-2, HER2 were studied to assess whether the biological behavior of grade I meningiomas is related their expression. Tissue samples from 96 patients with intracranial analyzed by immunohistochemistry on tissue microarray blocks (TMA) using antibodies specific for HLA-G, HLA-E, PR, ER, AR, HER2. Meningiomas classified as small (≤2 cm, 1.0%), medium (>2 ≤4 32.3%), large (>4 66.7%). Tumor size...

ABSTRACT Objectives: to develop and validate a diabetes booklet for Community Health Workers. Methods: methodological study developed in seven steps: Bibliographic review; Development of the booklet; Calculation readability comprehensibility scores; Validation by committee judges; Discussion between experts; target audience; Final discussion experts. was performed 10 judges via e-Surv on face-to-face test with 5 Workers, considering minimum Content Validity Coefficient 0.80. Results: had...

Androgen deprivation therapy (ADT) is the mainstay of for advanced prostate cancer. Studies addressing efficacy different depot formulations long acting luteinizing hormone releasing agonists in Brazilian population are lacking. We aimed to compare three schedules leuprolide acetate lowering PSA a real world population.We reviewed medical records patients with cancer seen at our institution between January 2007 and July 2018. analyzed treated long-acting grouped these into strata according...

Dengue is a public health problem in Brazil. Therefore, this study aimed to analyze factors associated with deaths from dengue residents of the municipality Contagem, Metropolitan Region Belo Horizonte, state Minas Gerais, Brazil, during 2016 epidemic.To determine due dengue, we used logistic regression model (univariate and multivariable) which response variable (outcome) was death dengue. Independent variables analyzed included demographic those related symptoms, treatment,...

To evaluate the introduction of coaching in interdisciplinary care individuals with type 1 diabetes mellitus public health system.Ten patients routinely attending a service and glycated hemoglobin (HbA1c) level above 75% participated eight sessions. This study evaluated patients' self-management disease personal behavior. The participants were assessed at beginning program on two occasions after intervention, evaluation biochemical anthropometric data, frequency self-monitoring blood glucose...

to elaborate an e-book about children and adolescents' rights duties concerning diabetes in schools.we developed this methodological study nine steps: Creation process definition, bibliographic survey, elaboration, readability apprehensibility examination, illustration, committee of judges targeted audience validation (students' moms with school staff), experts' meetings final discussion. We have considered acceptable the Content Validity Coefficient minimum 0.80.we obtained average 0,97 for...

Objective: To evaluate prognostic factors and survival determinants of patients with prostate cancer (PC) admitted to an oncology hospital. Methods: Retrospective cohort study on 3,450 medical records undergoing treatment from 2009 2018, follow-up until 2020, at the Center for High Complexity in Oncology (CACON), Muriaé, Minas Gerais, Brazil. Overall was estimated using Kaplan-Meier method. For paired comparisons, log-rank test used. multivariate analysis, Cox Proportional Hazards Results:...

e17065 Background: The Gleason Score (GS) is a fundamental prognostic indicator in prostate adenocarcinoma. Despite this significant clinical relevance, the determinants underlying disease aggressiveness relation to GS remain largely unknown. To explore gene expression profiles among patients diagnosed with metastatic adenocarcinoma, considering variation. Methods: This study prospective nature and was approved by CONEP-SCBH-CAAE 42638620.3.0000.5138. included 30 histologically confirmed...

e17066 Background: The need to identify genetic, prognostic and predictive markers for prostate cancer (PC), metastatic or not, is fundamental choosing the best treatment. Prevalence of pathogenic DNA damage repair (gDDR) mutations, mainly BRCA2 (gBRCA), was identified in Anglo-American populations with mPC (5.3%), Chinese (4.3%), Spanish (3.3%) Italian (3%). In this sense, highlighting similarities discrepancies genetic changes different important development therapeutic strategies. To...

Objective: The aim of this study was to describe the initial experience applying vacuum-assisted excision (VAE) associated with cavity margins sampling shaving (CMSH) breast lesions (BL), smaller than 15 mm and suspected malignancy, as a single-step approach in diagnosing treating early cancers (EBC). Methodology: An open interventional conducted recruiting patients Category 4 5 ACR BI-RADS™ BL, mm, candidates for VAE. Patients diagnosed multifocal/multicentric cancer (BC) were excluded. VAE...

Breast cancer is the leading type among women globally, and its chemotherapy often results in multiple side effects, compromising patient's quality of life. Our study aimed to analyze impact neoadjuvant on life Brazilian with breast within public health system. This research was a one-year, observational, longitudinal study, conducted at charitable facility, examining effect these women's Sociodemographic clinical data were extracted from medical records. Quality parameters gauged using...

Early identification of COVID-19 symptoms and burnout among residents is essential for proper management. Digital assistants might help in the large-scale screening residents.To assess implementation a chatbot tele-screening emotional exhaustion at hospital Brazil.From August to October 2020, sent participants' phones daily question about weekly exhaustion. After 8 weeks, answered Maslach Burnout Inventory-Human Services Survey (MBI-HSS). The primary outcome was reliability identifying...

Background: Several tools are available for predicting the risk of anastomotic leakage (AL) in patients undergoing colectomy colorectal cancer (CRC) treatment. However, these prognostic indexes have limitations applicability and efficiency.
 Aim: Developing validated, efficient easily applicable to help physicians predict AL.
 Methods: From a meta-analysis retrospective cohort, factors associated with development AL were used construct validate two new (Urgency Index Preoperative...

RESUMO Analisa o perfil das demandas por levantamento bibliográfico no Serviço de Referência da Biblioteca Hospitalar. Trata-se pesquisa retrospectiva, com amostra 189 formulários solicitados entre 2016 e 2021. Entre os solicitantes do predominou sexo masculino (50,8%), tempo médio gasto para realização foi 6,5 (±7,1) dias. As especialidades que mais solicitaram serviço foram ginecologia (12,2%), mastologia (11,6%) cirurgia geral (11,6%). abordagens procuradas se relacionaram ao tratamento...

To develop, adapt and validate an instrument named "CSII - Brazil" to assess users' conceptual procedural knowledge of continuous subcutaneous insulin infusion systems.Methodological exploratory study developed in three stages: a) development; b) content validation cultural adaptation (evaluation by a committee experts pre-test with CSII users); c) psychometric through application sample 60 patients means the web tool e-Surv. Internal consistency reproducibility analyses were performed...

Objective : To determine the association between Type 2 diabetes mellitus (T2DM) and inflammation based on plasma levels of pro-inflammatory cytokines (IL-1b, IL-6, TNF-a IFN-g), lipid peroxidation (malonaldehyde), vascular endothelial growth factor (VEGF) C-reactive protein (CRP) associated with glycated hemoglobin (HbA1c). Methods The expression oxidative stress markers angiogenic inflammatory were determined in 51 T2DM patients compared 38 healthy controls. CRP measured using ELISA. Lipid...