A5091850821- Advanced Glycation End Products research
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Immune Response and Inflammation
- Diabetes and associated disorders
- Adipokines, Inflammation, and Metabolic Diseases
- Natural Antidiabetic Agents Studies
- Biochemical Acid Research Studies
- Genomics, phytochemicals, and oxidative stress
- Peroxisome Proliferator-Activated Receptors
- Neuropeptides and Animal Physiology
- Amyotrophic Lateral Sclerosis Research
- Trauma, Hemostasis, Coagulopathy, Resuscitation
- RNA regulation and disease
- Muscle and Compartmental Disorders
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Atherosclerosis and Cardiovascular Diseases
- Neurological Disorders and Treatments
- Systemic Lupus Erythematosus Research
- Signaling Pathways in Disease
- Apelin-related biomedical research
- Trypanosoma species research and implications
- Mitochondrial Function and Pathology
- Immune cells in cancer
- Bone health and treatments
- Inflammasome and immune disorders
Grupo Santa Casa de Belo Horizonte
2012-2024
Santa Casa Hospital
2020-2022
Instituto de Ensino e Pesquisa Santa Casa
2011-2021
Fundação Oswaldo Cruz
2016
Weatherford College
2011
University of Florence
2010
We examined nitric oxide (NO), IL-6, and TNF-<mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" id="M1"><mml:mrow><mml:mi>α</mml:mi></mml:mrow></mml:math>secretion from cultured palmitate-stimulated PBMNCs or in the plasma type 2 diabetes mellitus (T2MD) patients nondiabetic (ND) controls. Free fatty acids (FFA) have been suggested to induce chronic low-grade inflammation, activate innate immune system, cause deleterious effects on vascular cells other tissues through inflammatory...
To evaluate inflammatory, oxidizing, and reducing responses during the progression of type 1 diabetes mellitus (T1DM) in patients without chronic complications.Plasma antioxidant status, reactive oxygen species (ROS), interleukin-6 (IL-6) were measured 42 with T1DM 24 healthy subjects.Significant increases detected median values ROS IL-6 compared subjects (ROS ~ 4,836 vs. 2,036 RLU/min, respectively; P < .05: 14.2 9.7 pg/mL, = .002). No significant between-group differences (P > 0.05)...
Obesity, type 2 diabetes, insulin resistance, dyslipidemia, cardiovascular diseases and atherosclerosis have all been associated with high levels of free fatty acid (FFA). In the present review, we suggest that FFA may act as either pro- or anti-inflammatory agents depending on chemical structure. Saturated acids (SFA) polyunsaturated (PUFA) significantly differ in their contributions to inflammation. While SFAs shown induce inflammation, PUFAs effects by downregulating NF-kappaB, IL-1β,...
Malondialdehyde (MDA), an end product of lipid peroxidation and biomarker for oxidative stress, its soluble receptor (sRAGE) were evaluated in 42 patients with type 1 diabetes mellitus, but without chronic complications, during the early years after diagnosis (0–10 years) through further progression disease (10–20 > 20 diagnosis). Clinical biochemical parameters cohort diabetic compared those determined 24 healthy individuals. The median levels MDA plasma similar subjects. In contrast,...
Oxidative stress is associated with the pathogenesis of MS. Edaravone (EDV) has been proposed as a therapeutic resource for central nervous system diseases, and it was effective in reducing oxidative stress. However, antioxidant mechanisms EDV are poorly studied.This study aimed to evaluate effects on resting, phagocytosis, PKC-activated granulocytes derived from MS patients healthy control group.The ROS production phagocytosis (ROS presence opsonized particles) PKC-stimulated were evaluated...
High mobility group box 1 (HMGB1) has been studied as a molecule associated with severe outcomes in sepsis and thrombomodulin (TM) seems to decrease HMGB1 activity.To investigate the role of thrombomodulin/high (T/H) ratio patients their association clinic, testing hypothesis that higher ratios are better outcomes.Twenty diagnosed or septic shock, according 2016 criteria shock (Sepsis-3), were studied. Patients followed until they left intensive care unit achieved 28 d hospitalization (D28)....
The mutated VAPBP56S (vesicle B associated membrane protein - P56S) has been described in a Brazilian family and classified as Amyotrophic Lateral Sclerosis type 8 (ALS8).
Atorvastatin (ATV) inhibits the conversion of 3-Hydroxy-3-Methylglutaryl Coenzyme A (HMG-CoA) to mevalonate formation and promotes lowering LDL cholesterol fraction. However, ATV exhibits pleiotropic metabolic actions beyond cholesterol-lowering properties. We aimed evaluate effect on oxidizing species generation cytokine secretion in Peripheral Blood Mononuclear Cells (PBMNC) Type 2 Diabetes Mellitus (T2DM) patients comparison healthy control. Both NADPH-oxidase-dependent mitochondrial ROS...
Background: Inflammation plays a significant role in the pathophysiology of Acute Coronary Syndrome (ACS) but is not included current risk stratification. Objective: This study aimed at determining association between thrombolysis Myocardial Infarction (TIMI) score and inflammatory biomarkers ACS, including unstable angina (UA), non-ST segment elevation myocardial infarction (NSTEMI), ST-segment (STEMI). We hypothesized that could add prognostic value to TIMI score. Methods: In this...
Aim: Neuroinflammation is a characteristic of multiple sclerosis (MS). Resveratrol (RSV) has potent antioxidant properties and emerged as promising therapeutic agent for various inflammatory diseases. This study investigated the effects RSV on responses via reactive oxygen species (ROS) production leukocyte cytokine secretion in patients with MS healthy controls. Methods: The ROS resting stimulated granulocytes (in presence opsonized particles) were assessed using luminol-dependent...
Aim & background: Pyruvate is considered as an anti-inflammatory and anti-oxidant produced from glucose metabolism. We examined the effects of sodium pyruvate on reactive oxygen species (ROS) production induced by opsonized particles in phagocytosing or toll-like receptor 4 (TLR4)-stimulated granulocytes obtained type 2 diabetic (T2DM) patients compared with those healthy individuals. Methods: Luminol-dependent chemiluminescence was used to quantify ROS generated. The phagocytosis T2DM...
Objective : To determine the association between Type 2 diabetes mellitus (T2DM) and inflammation based on plasma levels of pro-inflammatory cytokines (IL-1b, IL-6, TNF-a IFN-g), lipid peroxidation (malonaldehyde), vascular endothelial growth factor (VEGF) C-reactive protein (CRP) associated with glycated hemoglobin (HbA1c). Methods The expression oxidative stress markers angiogenic inflammatory were determined in 51 T2DM patients compared 38 healthy controls. CRP measured using ELISA. Lipid...