A5085092121- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Immune Response and Inflammation
- Neuropeptides and Animal Physiology
- Endoplasmic Reticulum Stress and Disease
- Advanced Glycation End Products research
- Acute Myocardial Infarction Research
- Biomarkers in Disease Mechanisms
- Multiple Sclerosis Research Studies
- Apelin-related biomedical research
- Blood disorders and treatments
- Genomics, phytochemicals, and oxidative stress
- Signaling Pathways in Disease
- Pharmacological Effects of Natural Compounds
- Natural Antidiabetic Agents Studies
- Adipokines, Inflammation, and Metabolic Diseases
- Biochemical Acid Research Studies
- Amyotrophic Lateral Sclerosis Research
- RNA regulation and disease
- Autophagy in Disease and Therapy
- Inflammation biomarkers and pathways
- Sirtuins and Resveratrol in Medicine
Grupo Santa Casa de Belo Horizonte
2018-2024
Santa Casa Hospital
2022
Instituto de Ensino e Pesquisa Santa Casa
2021
Oxidative stress is associated with the pathogenesis of MS. Edaravone (EDV) has been proposed as a therapeutic resource for central nervous system diseases, and it was effective in reducing oxidative stress. However, antioxidant mechanisms EDV are poorly studied.This study aimed to evaluate effects on resting, phagocytosis, PKC-activated granulocytes derived from MS patients healthy control group.The ROS production phagocytosis (ROS presence opsonized particles) PKC-stimulated were evaluated...
The mutated VAPBP56S (vesicle B associated membrane protein - P56S) has been described in a Brazilian family and classified as Amyotrophic Lateral Sclerosis type 8 (ALS8).
Background: Inflammation plays a significant role in the pathophysiology of Acute Coronary Syndrome (ACS) but is not included current risk stratification. Objective: This study aimed at determining association between thrombolysis Myocardial Infarction (TIMI) score and inflammatory biomarkers ACS, including unstable angina (UA), non-ST segment elevation myocardial infarction (NSTEMI), ST-segment (STEMI). We hypothesized that could add prognostic value to TIMI score. Methods: In this...
Aim: Neuroinflammation is a characteristic of multiple sclerosis (MS). Resveratrol (RSV) has potent antioxidant properties and emerged as promising therapeutic agent for various inflammatory diseases. This study investigated the effects RSV on responses via reactive oxygen species (ROS) production leukocyte cytokine secretion in patients with MS healthy controls. Methods: The ROS resting stimulated granulocytes (in presence opsonized particles) were assessed using luminol-dependent...
Background: Type 2 diabetes (DM2) and chronic kidney disease (CKD) are inflammatory pathologies. Diabetes is characterized by hyperglycemia CKD the gradual irreversible loss of function. Both diseases develop oxidative stress, reactive oxygen species (ROS) play a pivotal role in pathogenesis. This study aimed to determine ROS production granulocytes from renal patients with or without diabetes. Methods: Granulocytes DM2, CKD, CKD-DM2, healthy controls were purified using Ficoll-Hypaque...