A5102730871- Inflammatory Bowel Disease
- Microscopic Colitis
- Autoimmune and Inflammatory Disorders
- Tuberculosis Research and Epidemiology
- Eosinophilic Esophagitis
- COVID-19 and healthcare impacts
- Healthcare professionals’ stress and burnout
- Pregnancy and Medication Impact
- Pelvic floor disorders treatments
- Colorectal Cancer Screening and Detection
- Diverticular Disease and Complications
- Diversity and Career in Medicine
- Helicobacter pylori-related gastroenterology studies
- Adolescent and Pediatric Healthcare
- Medical Malpractice and Liability Issues
- T-cell and B-cell Immunology
- Hemoglobinopathies and Related Disorders
- Potassium and Related Disorders
- Cytokine Signaling Pathways and Interactions
- Mycobacterium research and diagnosis
- Reproductive System and Pregnancy
- Patient Safety and Medication Errors
- Single-cell and spatial transcriptomics
- Urological Disorders and Treatments
- Biosimilars and Bioanalytical Methods
National University Hospital
2013-2021
National University of Singapore
2021
Joint Base San Antonio
2017
Brooke Army Medical Center
2017
UNSW Sydney
2016
Hospital Alemán
2016
Liverpool Hospital
2016
Kardiologie Frankfurt-Sachsenhausen
2016
Crohn's and Colitis UK
2016
Vifor Pharma (Switzerland)
2016
<h3>Objective</h3> The rising incidence of inflammatory bowel disease in Asia supports the importance environmental risk factors aetiology. This prospective population-based case-control study Asia-Pacific examined prior to patients developing IBD. <h3>Design</h3> 442 incident cases (186 Crohn9s (CD); 256 UC; 374 Asians) diagnosed between 2011 and 2013 from eight countries Australia 940 controls (frequency-matched by sex, age geographical location; 789 completed an factor questionnaire at...
Living in an urban environment may increase the risk of developing inflammatory bowel disease (IBD). It is unclear if this observation seen globally. We conducted a population-based study to assess relationship between urbanization and incidence IBD Asia-Pacific region.Newly diagnosed cases 2011 2013 from 13 countries or regions were included. Incidence was calculated with 95% confidence interval (CI) pooled using random-effects model. Meta-regression analysis used rates their association...
Abstract Background This study aims to characterize, the gut and oral microbiome in Asian subjects with Crohn’s disease (CD) using whole genome shotgun sequencing, thereby allowing for strain-level comparison. Methods A case–control age, sex ethnicity matched healthy controls was conducted. CD were limited well-controlled patients without manifestations. Fecal saliva samples collected characterization of respectively. Microbial DNA extracted, libraries prepared sequenced reads profiled....
Chronic mucosal inflammation is associated with a greater risk of gastric cancer (GC) and, therefore, requires tight control by suppressive counter mechanisms. Gastrokine-2 (GKN2) belongs to family secreted proteins expressed within normal cells. GKN2 expression frequently lost during GC progression, suggesting an inhibitory role; however, causal link remains unsubstantiated. Here, we developed Gkn2 knockout and transgenic overexpressing mice investigate the functional impact loss in...
Abstract Background and Aims Poor knowledge of inflammatory bowel disease [IBD] in pregnancy underlies unwarranted voluntary childlessness [VC], risks poorer obstetric outcomes adverse fetal outcomes. IBD is increasing worldwide but education on issues might be heterogeneous based cultural differences variations models care. Methods Consecutive female subjects aged 18–45 years were prospectively recruited from two dedicated IBD-pregnancy clinics, multidisciplinary clinics nine general...
Anti-tumor necrosis factor (TNF) antibodies are effective in maintaining remission Crohn's disease. However, a significant proportion of patients lose response to these agents with time. This study aimed determine whether the introduction thiopurine who have lost anti-TNF monotherapy results regained response.Five (four males; aged 22-38 years) active disease, had an initial therapy but response, were commenced on azathioprine or mercaptopurine at standard doses while continuing therapy. All...
Persons with inflammatory bowel disease (IBD) may be particularly vulnerable to COVID-19 either because of their underlying or its management. Guidance has been presented on the management persons IBD in time this pandemic by different groups. We aimed determine how gastroenterologists around world were approaching IBD.
Mucosal healing is associated with improved long-term clinical outcomes in patients ulcerative colitis. This population-based study assessed endoscopic and histological mucosal within the first year of diagnosis.Consecutive diagnosed colitis from six countries Asia were prospectively enrolled. Clinical demographics, blood markers inflammatory activity at baseline. Mayo score Nancy index used to assess activities, respectively. Clinical, evaluations repeated 1 year. Logistic regression was...
Abstract Background Physician adherence to guidelines for colorectal cancer ( CRC ) surveillance in inflammatory bowel disease IBD is often poor. This may lead adverse patient outcomes and excess endoscopic workload. Aims To assess the attitudes practice of specialists a tertiary centre towards colonoscopic surveillance. Methods First, questionnaire evaluating approach was issued 36 clinicians at one referral hospital. Second, retrospective audit colonoscopy over 2‐year period performed....
Crohn's disease (CD) is increasing in incidence and prevalence Asia, but there a paucity of population-based studies on risk factors for surgery Asian patients with CD. This will be useful to identify who may benefit from top-down treatment. study describes the rates abdominal identifies associated Singaporean CD.This was retrospective observational study. The medical records Singaporeans diagnosed CD 1970 2013 were reviewed 8 different hospitals Singapore. cumulative probability CD-related...
INTRODUCTION. Tumour cell implantation is a rare complication in patients with head and neck cancers, who have undergone percutaneous endoscopic gastrostomy (PEG) tube placement. It has not been reported underwent PEG insertion via the radiological or introducer technique. We describe novel case presentation of metastatic disease patient placement (Russell) technique which, to best our knowledge, previously described. CASE PRESENTATION. The was 37-year-old Malay woman developed squamous...
The coronavirus disease 2019 pandemic has impacted gastroenterology practices worldwide; however, its protracted effects within Southeast Asia were unknown. primary aim of the study was to determine impact on clinical demands including burnout among gastroenterologists region. secondary identify risk factors for and regional stressors.This a mixed-methods study. Gastroenterologists surveyed electronically between September 1 December 7, 2020, via endoscopy societies Brunei, Indonesia,...
Background/Aims To examine the association between use of oral contraceptive pills (OCPs) and risk developing inflammatory bowel diseases (IBD), in a modern cohort. Methods A prospective nested case-control study across sites Asia-Pacific region was conducted; involving female IBD cases asymptomatic controls. Subjects completed questionnaire addressing questions related to OCP use. Primary outcome development those exposed versus non-exposure. Secondary outcomes were Crohn's disease (CD)...
Real-world clinical data on the use of vedolizumab in patients with inflammatory bowel disease (IBD) is lacking Asian populations. We aim to report efficacy and safety outcomes a nation-wide cohort Singapore. A retrospective study adult IBD from 6 largest local hospitals who completed induction between 2015 2018 was conducted. The primary outcome measure steroid-free remission (SFCR) at 14, 24 54 weeks after initiation therapy. SFCR defined as complete tapering steroids absence symptoms...
Background: Initial management of urethral injury remains controversial concerning the use suprapubic urinary diversion and delayed repair, primary open realignment, endoscopic realignment. To our knowledge, we present first reported case a penetrating because an animal attack, without concomitant extragenitourinary system involvement, managed entirely endoscopically. Case Presentation: This is 82-year-old male who presented to emergency department after attack by semidomesticated deer. He...
Background Clinician burnout is an important occupational hazard that may be exacerbated by the novel COVID-19 pandemic. Within Southeast Asia, in gastroenterology understudied. The primary objective of this study to estimate prevalence symptoms within gastroenterology, member states Associations Asian Nations (ASEAN), during and after secondary identify work-related stressors contribute ASEAN gastroenterologists. Methods analysis This observational will use anonymised online surveys at two...