A5007525354- Inflammatory Bowel Disease
- Microscopic Colitis
- Eosinophilic Esophagitis
- Colorectal Cancer Screening and Detection
- Liver Disease Diagnosis and Treatment
- Gastroesophageal reflux and treatments
- Gastric Cancer Management and Outcomes
- Hepatitis B Virus Studies
- Autoimmune and Inflammatory Disorders
- Tuberculosis Research and Epidemiology
- Gastrointestinal Bleeding Diagnosis and Treatment
- Gastrointestinal motility and disorders
- Helicobacter pylori-related gastroenterology studies
- Diverticular Disease and Complications
- Foreign Body Medical Cases
- Liver Diseases and Immunity
- COVID-19 Clinical Research Studies
- Nutrition and Health in Aging
- Diagnosis and treatment of tuberculosis
- Potassium and Related Disorders
- Diagnosis and Treatment of Venous Diseases
- SARS-CoV-2 and COVID-19 Research
- Pathogenesis and Treatment of Hiccups
- Celiac Disease Research and Management
- Health Systems, Economic Evaluations, Quality of Life
National University Hospital
2012-2024
National University of Singapore
2013-2024
National University Health System
2017-2023
Yong In University
2021
University of Malaya
2010-2014
The utility of neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte (PLR) in predicting immune-related adverse events (irAEs) survival have not been well studied the context treatment with immune checkpoint inhibitors (ICIs). We performed a case-control study cancer patients who received at least one dose ICI tertiary hospital. examined NLR PLR irAE cases controls. Logistic Cox regression models were used to identify independent risk factors for irAEs, progression-free (PFS),...
To examine the differences in prevalence and severity of anxiety depression patients with functional dyspepsia (FD), nonerosive reflux disease (NERD), irritable bowel syndrome (IBS) healthy controls.Consecutive undergoing an index endoscopic examination for various symptoms were interviewed. All three gastrointestinal disorders (FGIDs) diagnosed according to Rome III criteria. Anxiety using a locally validated version hospital scale.A total 248 recruited (62 FD, NERD, IBS control groups...
Abstract BACKGROUND Rising incidence and prevalence of inflammatory bowel disease (IBD) observed historically in early-industrialized regions now also appear newly-industrialized emerging regions. The epidemiology IBD has been proposed to progress across epidemiologic stages: 1. Emergence (low prevalence); 2. Acceleration Incidence (rapid rising incidence); 3. Compounding Prevalence (stabilizing incidence, rapid prevalence). AIM To gather real-world data on the characterize global each stage...
Anti-tumor necrosis factor (TNF) antibodies are effective in maintaining remission Crohn's disease. However, a significant proportion of patients lose response to these agents with time. This study aimed determine whether the introduction thiopurine who have lost anti-TNF monotherapy results regained response.Five (four males; aged 22-38 years) active disease, had an initial therapy but response, were commenced on azathioprine or mercaptopurine at standard doses while continuing therapy. All...
Microbiome dysbiosis is associated with inflammatory destruction in Crohn's disease [CD]. Although gut microbiome well established CD, the oral comparatively under-studied. This study aims to characterize of CD patients with/without manifestations. Patients were recruited age-, gender- and race-matched controls. Potential confounders such as dental caries periodontal condition recorded. The was collected using saliva samples. Microbial DNA extracted sequenced shotgun sequencing. Metagenomic...
Hepatocellular carcinoma (HCC) is an important cancer in Malaysia. This study aimed to determine the epidemiological characteristics and clinical presentations of patients a multiracial population consisting three major Asian races: Malays, Chinese Indians.Consecutive with HCC were prospectively studied from 2006 2009. was diagnosed principally on multiphasic computed tomography magnetic resonance imaging scans liver. The tumor staged according Barcelona Clinic Liver Cancer (BCLC)...
Objective Patients with ulcerative colitis (UC) diagnosed low-grade dysplasia (LGD) have increased risk of developing advanced neoplasia (AN: high-grade or colorectal cancer). We aimed to develop and validate a predictor AN in patients UC LGD create visual web tool effectively communicate the risk. Design In our retrospective multicentre validated cohort study, adult an index diagnosis LGD, identified from four UK centres between 2001 2019, were followed until progression AN. discovery...
Summary Background Chronic hepatitis B patients ( CHB ) treated with adefovir were followed up to evaluate nephrotoxicity and its outcome. Aim To assess the incidence of renal dysfunction during therapy in Asian factors associated it, strategies improve adefovir‐related their impact on viral suppression. Methods clinic from a tertiary hospital treatment, clinical laboratory parameters extracted electronic database an observational study design. Patients excluded if they had liver/renal...
There is increasing evidence for the role of microscopic inflammation in patients with IBS. We aimed to examine prevalence colitis and Malaysian IBS diarrhoea (IBS-D). Consecutive who met Rome III criteria IBS-D asymptomatic controls were prospectively recruited. Colonoscopy was performed all study subjects systematic biopsies taken from segments colon. The diagnosis lymphocytic collagenous made using previously defined criteria. Patients post infectious excluded. 120 (74 IBS-D, 46 controls)...
Summary Background Little is known of the outcome patients with perianal Crohn's disease after stopping anti‐tumour necrosis factor (TNF) therapy. Aim To evaluate rate relapse in (CD) anti‐TNF Methods Consecutive CD treated therapy subsequent discontinuation were retrieved from prospective inflammatory bowel database institutes Hong Kong, Shanghai, Taiwan, Malaysia, Thailand and Singapore 1997 to June 2019. Cumulative probability was estimated using Kaplan‐Meier method. Results After a...
Abstract During the 20th century, inflammatory bowel disease (IBD) was considered a of early-industrialized regions in North America, Europe, and Oceania. At turn 21st incidence IBD increased newly-industrialized emerging Africa, Asia, Latin while prevalence started to grow steadily. Changes denote evolution across four epidemiologic stages: Stage 1 (Emergence), characterized by low prevalence; stage 2 (Acceleration Incidence), rapidly rising 3 (Compounding Prevalence), decelerating,...
Abstract Background Dietary beliefs and behaviors in IBD patients may affect both clinical outcome psychosocial aspect of patients’ lives. New emerging studies have shown varying efficacy different diets inducing maintaining remission patients. This study aims to investigate the dietary beliefs, barriers, acceptability diet among Asia-Pacific region. Methods A multi-centre survey was conducted across 4 countries Asia-Pacific. An anonymized online electronic disseminated at 10 participating...
BACKGROUND Genetic factors play an important role in the pathogenesis and development of metabolic dysfunction-associated fatty liver disease (MAFLD). AIMTo study association single nucleotide polymorphisms (SNPs), previously identified Western populations, with risk MAFLD a Singapore Chinese population their interactions environmental medical factors. METHODSA retrospective case-control was conducted 72 cases controls no hepatic steatosis on computed tomography, magnetic resonance imaging,...
Despite the widespread use of transient elastography for non-invasive assessment liver fibrosis, optimal cut-off stiffness measurement (LSM) values remain unclear. This study aimed to validate LSM significant fibrosis and cirrhosis in patients with chronic disease (CLD).Prospective multicentre data CLD who underwent paired biopsy was analysed determine predicting (METAVIR F ≥ 2) F4). A high-quality cohort selected by excluding those failed invalid readings.Of 481 recruited, 322 fulfilled...
Antiplatelet agents and anticoagulants make up the larger group of antithrombotic medications, which have seen increasing use worldwide as populations in developed countries age, ischemic heart disease prevalence rises. Antithrombotic medications reduce risk thromboembolic events susceptible individuals, but increase gastrointestinal bleeding. Cessation drugs prior to endoscopic therapy has been proposed, aimed at reducing immediate early However, interruption is associated with...
Abstract BACKGROUND Epidemiologic stages of inflammatory bowel disease (IBD) have been proposed: 1. Emergence (low incidence and prevalence); 2. Acceleration in Incidence (rapidly rising incidence, low 3. Compounding Prevalence (stabilizing rapidly prevalence). To date, these theoretical without quantified definitions prevalence. AIM use machine learning to determine prevalence ranges corresponding the epidemiologic provide stage classifications across time for global regions. METHODS We...
Abstract BACKGROUND A theoretical framework for population-level transition across four epidemiologic stages has been proposed inflammatory bowel disease (IBD): 1. Emergence (low incidence/prevalence); 2. Acceleration in Incidence (rapid rising incidence); 3. Compounding Prevalence (stabilizing incidence, rapid prevalence); and 4. Equilibrium (decelerated prevalence), which no region entered yet. Many regions of the early-industrialized world (North America, Europe, Oceania) are currently...