A5029169332- Inflammatory Bowel Disease
- Colorectal Cancer Screening and Detection
- Microscopic Colitis
- Gastric Cancer Management and Outcomes
- Diverticular Disease and Complications
- Genetic factors in colorectal cancer
- COVID-19 and healthcare impacts
- Esophageal Cancer Research and Treatment
- Diagnosis and treatment of tuberculosis
- Mycobacterium research and diagnosis
- Lung Cancer Treatments and Mutations
- Celiac Disease Research and Management
- Appendicitis Diagnosis and Management
- Healthcare cost, quality, practices
- Advanced Proteomics Techniques and Applications
- Global Health Workforce Issues
- Gastrointestinal Bleeding Diagnosis and Treatment
- COVID-19 diagnosis using AI
- Artificial Intelligence in Healthcare and Education
- Climate Change and Health Impacts
- Cancer Immunotherapy and Biomarkers
- Treatment of Major Depression
- Healthcare Systems and Challenges
- Streptococcal Infections and Treatments
- Anorectal Disease Treatments and Outcomes
University College London
2008-2025
University College Hospital
2017-2025
University College London Hospitals NHS Foundation Trust
2018-2024
Imperial College London
2014-2023
University College Cork
2023
SGS Germany GmbH (Germany)
2023
Cork University Hospital
2023
Whittington Health NHS Trust
2022
St. Mark's Hospital
2019-2022
British Society for Haematology
2022
Abstract Background Small bowel capsule endoscopy (SBCE) has the highest sensitivity and specificity for identifying Crohn’s disease (CD) affecting small bowel. The recent CURE-CD study demonstrated that proactive treatment optimisation with SBCE monitoring led to improved outcomes. [1] We performed a retrospective cohort at tertiary centre in UK evaluate impact of management disease. Methods reviewed database from December 2021 – 2022. 181 were this time period. included patients who either...
Patients with inflammatory bowel disease (IBD) remain at increased risk for colorectal cancer and death from compared the general population despite improvements in inflammation control advanced therapies, colonoscopic surveillance reductions environmental factors. This guideline update 2010 of patients over 16 years colonic was developed by stakeholders representing UK physicians, endoscopists, surgeons, specialist nurses GRADE (Grading Recommendations Assessment, Development Evaluation)...
There are no universally accepted guidelines regarding surveillance of ulcerative colitis [UC] patients after restorative proctocolectomy and ileal pouch-anal anastomosis [IPAA]. also exists a lack validated quality assurance standards for performing pouchoscopy. To better understand IPAA practices in the face this clinical equipoise, we carried out retrospective cohort study at five inflammatory bowel disease [IBD] referral centres.Records who underwent UC or IBD unclassified [IBDU] were...
Objective Patients with ulcerative colitis (UC) diagnosed low-grade dysplasia (LGD) have increased risk of developing advanced neoplasia (AN: high-grade or colorectal cancer). We aimed to develop and validate a predictor AN in patients UC LGD create visual web tool effectively communicate the risk. Design In our retrospective multicentre validated cohort study, adult an index diagnosis LGD, identified from four UK centres between 2001 2019, were followed until progression AN. discovery...
Our aim was to determine aetiology of post-colonoscopy colorectal cancers (PCCRCs) identified from population-based data through local root cause analysis at a high-volume mixed secondary and tertiary referral centre.A subset national cancer registration data, collected by the National Cancer Registration Analysis Service, used PCCRCs diagnosed between 2005 2013 our centre.Root performed for each PCCRC, using World Endoscopy Organisation recommendations, validate it assess most plausible...
Ovarian cancer is characterized by vague, non-specific symptoms, advanced stage at diagnosis and poor overall survival. A nested case control study was undertaken on stored serial serum samples from women who developed ovarian healthy controls (matched for processing storage conditions as well attributes such age) in a pilot randomized controlled trial of screening. The unique feature this that the were screened up to 7 years. underwent prefractionation using reversed-phase batch extraction...
Inflammatory bowel disease [IBD] is associated with high rates of post-colonoscopy colorectal cancer [PCCRC], but further in-depth qualitative analyses are required to determine whether they result from inadequate surveillance or aggressive IBD evolution.
Objective The National Health Service (NHS) produces more carbon emissions than any public sector organisation in England. In 2020, it became the first health service worldwide to commit becoming net zero, same year as COVID-19 pandemic forced healthcare systems globally rapidly adapt delivery. As part of this, outpatient appointments largely remote. Although environmental benefit this change may seem intuitive impact on patient outcomes must remain a priority. Previous studies have...
people conclude too early that they understand it.
Inflammatory bowel disease colitis-associated dysplasia is managed with either enhanced surveillance and endoscopic resection or prophylactic surgery. The rate of progression to cancer after a diagnosis remains uncertain in many cases patients have high thresholds for accepting proctocolectomy. Individualised discussion management options encouraged take place between their multidisciplinary teams best outcomes. We aimed develop toolkit support structured, shared decision-making approach...
Abstract Aim In cases of prognostic uncertainty and equipoise as to the best management (prophylactic colectomy vs. surveillance) for dysplasia in inflammatory bowel disease (IBD), individualized discussion with patient is required. Further understanding patients' preferences needed. Methods A nationwide cross‐sectional survey was distributed adult IBD patients who had never been diagnosed (dysplasia‐naïve) those (dysplasia‐experienced). Risk perceptions factors that influence choices were...
<h3>Introduction</h3> Previous regional pilot studies have suggested that media campaigns for upper gastrointestinal (UGI) cancers successfully increase public awareness of symptoms, two-week wait pathway (2 WW) general practitioner (GP) referrals and the numbers diagnosed.<sup>1</sup> This prompted roll-out a nationwide televised campaign, which promoted dyspepsia as sign cancer, from 26 th January to 22 nd February 2015. study aimed evaluate its impact, is not well known date, on GP made...
The aim of this survey was to understand the impact COVID-19 pandemic and recovery phase on workload, well-being workforce attrition in UK gastroenterology hepatology.
Introduction The evolving landscape of inflammatory bowel disease (IBD) necessitates refining colonoscopic surveillance guidelines. This study outlines methodology adopted by the British Society Gastroenterology (BSG) Guideline Development Group (GDG) for updating IBD colorectal Methods and analysis ‘Grading Recommendations, Assessment, Evaluation’ (GRADE) approach, as outlined in GRADE handbook, was employed. Thematic questions were formulated using either ‘patient, intervention, comparison...
Background Accurate and detailed endoscopy reporting in ulcerative colitis (UC) is critical for clinical decision-making. High-quality involves inclusion of several criteria, previously identified by an independent group experts (Building Research IBD Globally (BRIDGe) group). Few studies have evaluated UC quality. Our aim was to evaluate the impact intervention bundle designed standardise improve reporting. Methods This included: integration a template into software; endoscopist training;...
Background: Malaria infection in children has been of concern this part the world - sub-Saharan Africa. This study was undertaken to determine prevalence deadly attending Usmanu Danfodiyo University Teaching Hospital (UDUTH) Sokoto.Materials and Methods: One hundred twenty four (124) capillary blood samples were collected from patients Emergency Pediatrics Unit side laboratory. The 'gold standard' method applied using Giemsa stain carry out investigation. Both thick thin films investigated...
A successful colitis cancer surveillance programme requires effective action to be taken when dysplasia is detected. This the first international cross-sectional study evaluate clinician understanding of dysplasia-cancer risk and management practice since most recent guidelines were introduced in 2015. 15-item online survey was disseminated gastroenterologists colorectal surgeons. total 294 clinicians [93.5% gastroenterologists] from 60 countries responded; 23% did not have access...
<h3>Introduction</h3> Perianal disease (PD; uncomplicated abscess and/or fistula) is a relatively common condition. There recognised association with Crohn9s (CD) and 11–26% of patients in paediatric1 adult2 case series are purported to develop intestinal CD. However, the temporal relationship unclear, as natural history PD. <h3>Methods</h3> This was single-centre (KCH) retrospective study cohorts having undergone medical or surgical therapy for PD since Jan 2008 (all after MRI) identified...
The natural history and prognosis of low-grade dysplasia (LGD) in ulcerative colitis (UC) is uncertain which makes communication to patients their colorectal cancer (CRC) risk management options (colectomy vs. enhanced colonoscopic surveillance) very challenging. An extensive analysis the significant factors outcomes 172 UC with histologically diagnosed LGD between January 1993 December 2012 from IBD surveillance database at St Mark’s Hospital has been reported by our team.1 Using these data...