A5084284002- Inflammatory Bowel Disease
- Colorectal Cancer Screening and Detection
- Microscopic Colitis
- Gastric Cancer Management and Outcomes
- Mycobacterium research and diagnosis
- Radiomics and Machine Learning in Medical Imaging
- Genetic factors in colorectal cancer
- Helicobacter pylori-related gastroenterology studies
- Colorectal Cancer Surgical Treatments
- Diagnosis and treatment of tuberculosis
- Eosinophilic Esophagitis
- AI in cancer detection
- Systemic Lupus Erythematosus Research
- Autoimmune and Inflammatory Disorders
- Autoimmune and Inflammatory Disorders Research
- Cytomegalovirus and herpesvirus research
- Appendicitis Diagnosis and Management
- Diverticular Disease and Complications
- Immunodeficiency and Autoimmune Disorders
- Esophageal Cancer Research and Treatment
- Celiac Disease Research and Management
- Immune Response and Inflammation
- Colorectal Cancer Treatments and Studies
- Barrier Structure and Function Studies
- Cancer-related molecular mechanisms research
University College London
2016-2025
University College London Hospitals NHS Foundation Trust
2014-2025
University College Hospital
2015-2024
University Gastroenterology
2016
Hospital Universitari Germans Trias i Pujol
2008
Universitat Autònoma de Barcelona
2008
Magnetic resonance enterography (MRE) and ultrasound are used to image Crohn's disease, but their comparative accuracy for assessing disease extent activity is not known with certainty. Therefore, we did a multicentre trial address this issue.
BackgroundCytomegalovirus (CMV) infection has been reported in ulcerative colitis (UC), especially severe, steroid-refractory disease. However, its role steroid-refractoriness remains unknown. Our goals were to evaluate the prevalence of CMV disease UC, best diagnostic strategy, and influence activity and/or treatment development.
IBD confers an increased lifetime risk of developing colorectal cancer (CRC), and colitis-associated CRC (CA-CRC) is molecularly distinct from sporadic (S-CRC). Here we have dissected the evolutionary history CA-CRC using multiregion sequencing.
OBJECTIVE: It has been suggested that, in inflammatory bowel disease, cytomegalovirus behaves the intestine as a nonpathogenic bystander, and even its finding intestinal mucosa unclear clinical relevance. We report our experience with small series of patients refractory disease infection their outcome. METHODS AND RESULTS: Nine moderate-severe attacks did not respond to i.v. prednisone (1 mg/kg/day) for mean 24 days. Four these were further treated cyclosporine A (4 mg/kg/day)....
Summary Background Magnetic resonance enterography ( MRE ) can measure small bowel motility, reduction in which reflects inflammatory burden Crohn's Disease CD ). However, it is unknown if motility improves with successful treatment. Aim To determine changes segmental reflect response to anti‐ TNF α therapy after induction and longer term. Methods A total of 46 patients (median 29 years, 19 females) underwent before treatment; 35 identified retrospectively repeat median 55 weeks treatment 11...
Crohn's disease is a chronic inflammatory condition largely affecting the terminal ileum and large bowel. A contributing cause failure of an adequate acute response as result impaired secretion pro-inflammatory cytokines by macrophages. This defective arises from aberrant vesicle trafficking, misdirecting to lysosomal degradation. Aberrant intestinal permeability also well-established in disease. Both disordered trafficking increased bowel could abnormal lipid composition. We thus measured...
Restorative proctocolectomy with ileal pouch–anal anastomosis is the operation of choice for patients treatment-refractory ulcerative colitis. However, after this intervention, up to 50% develop pouchitis. Moreover, a subgroup will also inflammation in afferent ileum proximal pouch, condition named prepouch ileitis (PI). Data on 546 who underwent colitis were retrospectively collected from 3 tertiary inflammatory bowel disease referral centers Netherlands, Belgium, and England. PI was...
Abstract Objectives Magnetic resonance enterography (MRE) is a first-line investigation to diagnose Crohn’s disease (CD), but its role for prognostication unknown. Accordingly, we assessed the predictive ability of prognostic models including MRE scores (MRE Global Score (MEGS), simplified MR Index Activity (sMARIA), and Lémann index (LI)) against using clinical predictors alone development modified Beaugerie disabling CD (MBDD) within 5 years diagnosis. Methods This was multicentre,...
There are no universally accepted guidelines regarding surveillance of ulcerative colitis [UC] patients after restorative proctocolectomy and ileal pouch-anal anastomosis [IPAA]. also exists a lack validated quality assurance standards for performing pouchoscopy. To better understand IPAA practices in the face this clinical equipoise, we carried out retrospective cohort study at five inflammatory bowel disease [IBD] referral centres.Records who underwent UC or IBD unclassified [IBDU] were...
Mucosal abnormalities are potentially important in the primary pathogenesis of ulcerative colitis (UC). We investigated mucosal transcriptomic expression profiles biopsies from patients with UC and healthy controls, taken macroscopically noninflamed tissue terminal ileum 3 colonic locations objective identifying abnormal molecules that might be involved disease development.Whole-genome transcriptional analysis was performed on intestinal 24 UC, 26 14 Crohn's disease. Differential gene at...
There is uncertainty regarding the efficacy of artificial intelligence (AI) software to detect advanced subtle neoplasia, particularly flat lesions and sessile serrated (SSLs), due low prevalence in testing datasets prospective trials. This has been highlighted as a top research priority for field.An AI algorithm was evaluated on four video test containing 173 polyps (35,114 polyp-positive frames 634,988 polyp-negative frames) specifically enriched with SSLs, including challenging dataset...
The simplified magnetic resonance enterography [MRE] index of activity [sMARIA], London, and 'extended' scoring systems are widely used in Crohn's disease [CD] to assess activity, although validation studies have usually been single-centre, retrospective, and/or few readers. Here, we evaluated these MRE indices within a prospective, multicentre, multireader, diagnostic accuracy trial.A subset participants [newly diagnosed or suspected relapse] recruited the METRIC trial with available...
To investigate the effect of tumour necrosis factor (TNF)-α antagonists on MRI dynamic contrast-enhanced (DCE) and diffusion-weighted imaging (DWI) parameters in Crohn's disease (CD).42 patients with CD (median age 24 years; 22 females) commencing anti-TNF-α therapy baseline follow-up 51 weeks) 1.5-T MR enterography (MRE) were retrospectively identified. MRE included DCE (n = 20) and/or multi-b-value DWI 17). Slope enhancement (SoE), maximum (ME), area under time-intensity curve (AUC),...
Objective Patients with ulcerative colitis (UC) diagnosed low-grade dysplasia (LGD) have increased risk of developing advanced neoplasia (AN: high-grade or colorectal cancer). We aimed to develop and validate a predictor AN in patients UC LGD create visual web tool effectively communicate the risk. Design In our retrospective multicentre validated cohort study, adult an index diagnosis LGD, identified from four UK centres between 2001 2019, were followed until progression AN. discovery...
Convolutional neural networks (CNN) for computer-aided diagnosis of polyps are often trained using high-quality still images in a single chromoendoscopy imaging modality with sessile serrated lesions (SSLs) excluded. This study developed CNN from videos to classify as adenomatous or nonadenomatous standard narrow-band (NBI) and NBI-near focus (NBI-NF) created publicly accessible polyp video database.
The inflammatory bowel diseases (IBD) are particularly common among the Ashkenazi Jewish (AJ) population. Population-specific estimates of familial risk important for counseling; however, relatively small cohorts AJ IBD patients have been analyzed to date. This study aimed recruit a new cohort patients, mainly from UK, determine occurrence disease. A total 864 were recruited through advertisements, hospital clinics, and primary care. Participants interviewed about their ancestry, disease...
Sequential drug treatment with biological agents in ulcerative colitis (UC) is becoming increasingly complex. There are few studies comparing head-to-head outcomes second-line treatments. The study assesses whether using anti-tumour necrosis factor (anti-TNF)-α therapy following the α4β7 integrin blocker vedolizumab (VDZ) or VDZ after an anti-TNF has more favourable clinical UC a real-world outpatient setting.Patients who were exposed to first-line (adalimumab infliximab) subsequently...
Abstract Background and Aim Lack of visual recognition colorectal polyps may lead to interval cancers. The mechanisms contributing perceptual variation, particularly for subtle advanced neoplasia, have scarcely been investigated. We aimed evaluate errors provide novel mechanistic insights. Methods Eleven participants (seven trainees four medical students) evaluated images from the UCL polyp perception dataset, containing 25 polyps, using eye‐tracking equipment. Gaze were defined as those...
Rare variants are thought to contribute the genetics of inflammatory bowel disease (IBD), which is more common amongst Ashkenazi Jewish (AJ) population. A family-based approach using exome sequencing AJ individuals with IBD was employed a view identify novel rare genetic for this disease. Exome performed on 960 including 513 from 199 multiplex families up eight cases. Rare, damaging in loci prioritized by linkage analysis and those shared multiple affected within same family were identified....