A5083387139- Genetic factors in colorectal cancer
- Colorectal Cancer Screening and Detection
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Inflammatory Bowel Disease
- Gastric Cancer Management and Outcomes
- Cancer Genomics and Diagnostics
- Colorectal Cancer Surgical Treatments
- Microscopic Colitis
- Colorectal Cancer Treatments and Studies
- Colorectal and Anal Carcinomas
- Multiple and Secondary Primary Cancers
- Diverticular Disease and Complications
- Cancer Immunotherapy and Biomarkers
- Liver Diseases and Immunity
- Gastrointestinal disorders and treatments
- Diagnosis and treatment of tuberculosis
- Helicobacter pylori-related gastroenterology studies
- Esophageal Cancer Research and Treatment
- Mycobacterium research and diagnosis
- Immunotherapy and Immune Responses
- Cancer-related gene regulation
- Celiac Disease Research and Management
- Neurofibromatosis and Schwannoma Cases
- Immune Cell Function and Interaction
- Pancreatic and Hepatic Oncology Research
St Mark's Hospital
2016-2025
London North West Healthcare NHS Trust
2016-2022
St. Mark's Hospital
2015-2021
Imperial College London
2012-2016
Color (United States)
2015
Wolfson Foundation
2015
University Hospitals Bristol NHS Foundation Trust
2010
Bristol Royal Infirmary
1999-2010
Royal Victoria Infirmary
1987
Objectives: This study provides an overview of the largest and longest-running colonoscopic surveillance program for colorectal cancer (CRC) in patients with long-standing ulcerative colitis (UC). Methods: Data were obtained from medical records, endoscopy, histology reports. Primary end points defined as death, colectomy, withdrawal surveillance, or censor date (1 January 2013). Results: A total 1,375 UC followed up 15,234 patient-years (median, 11 years per patient). CRC was detected 72...
Magnetic resonance enterography (MRE) and ultrasound are used to image Crohn's disease, but their comparative accuracy for assessing disease extent activity is not known with certainty. Therefore, we did a multicentre trial address this issue.
<h3>Background</h3> Accurate optical characterisation and removal of small adenomas (<10 mm) at colonoscopy would allow hyperplastic polyps to be left in situ surveillance intervals determined without the need for histopathology. Although accurate specialist practice performance narrow band imaging (NBI), routine clinical is poorly understood. <h3>Methods</h3> NBI-assisted diagnosis was compared with reference standard histopathological findings a prospective, blinded study, which...
Objective Ulcerative colitis (UC) is a dynamic disease with its severity continuously changing over time. We hypothesised that the risk of colorectal neoplasia (CRN) in UC closely follows an actuarial accumulative inflammatory burden, which inadequately represented by current stratification strategies. Design This was retrospective single-centre study. Patients extensive who were under colonoscopic surveillance between 2003 and 2012 studied. Each episode scored for microscopic inflammation...
OBJECTIVES: The aim of this study was to identify risk factors associated with development high-grade dysplasia (HGD) or colorectal cancer (CRC) in ulcerative colitis (UC) patients diagnosed low-grade (LGD). METHODS: Patients histologically confirmed extensive UC, who were LGD between 1993 and 2012 at St Mark's Hospital, identified followed up 1 July 2013. Demographic, endoscopic, histological data collected correlated the HGD CRC. RESULTS: A total 172 for a median 48 months from date...
IBD confers an increased lifetime risk of developing colorectal cancer (CRC), and colitis-associated CRC (CA-CRC) is molecularly distinct from sporadic (S-CRC). Here we have dissected the evolutionary history CA-CRC using multiregion sequencing.
The risk of developing advanced neoplasia (AN; colorectal cancer and/or high-grade dysplasia) in ulcerative colitis (UC) patients with a low-grade dysplasia (LGD) lesion is variable and difficult to predict. This major challenge for effective clinical management. We aimed provide accurate AN stratification UC LGD. hypothesised that the pattern burden somatic genomic copy number alterations (CNAs) LGD lesions could predict future risk. performed retrospective multicentre validated...
Evidence links chronic inflammation with cancer, but cellular mechanisms involved in this process remain unclear. We have demonstrated that humans, inflammatory conditions predispose to development of skin and colon tumors are associated accumulation tissues CD33+S100A9+ cells, the phenotype typical for myeloid-derived suppressor cells cancer or immature myeloid (IMCs) tumor-free hosts. To identify direct role these tumor development, we used S100A9 transgenic mice create topical absence...
Summary Background Preliminary data have suggested that interleukin‐2 receptor blockade with basiliximab may increase steroid sensitivity. We previously reported a small case series demonstrating the potential of as novel agent for treatment steroid‐resistant ulcerative colitis. Aim To report further experience efficacy and safety blocking monoclonal antibody basiliximab, in addition to steroids, severe moderate Methods Twenty patients were enrolled – 13 colitis (Ulcerative Colitis Symptom...
Sessile serrated adenomas/polyps (SSA/Ps) are frequently found in the proximal colon, where wall is thinner and easily damaged by diathermy during polypectomy, which also carries a risk of delayed bleeding, perforation, post-polypectomy syndrome. SSA/Ps often flat with subtle, irregular edges making endoscopic assessment their extent difficult [1]. This can lead to incomplete resection post-colonoscopy cancer [2].
BackgroundScreening for Barrett's oesophagus relies on endoscopy, which is invasive and few who undergo the procedure are found to have condition. We aimed use machine learning techniques develop externally validate a simple risk prediction panel screen individuals oesophagus.MethodsIn this prospective study, in (MARK-BE), we used data from two case-control studies, BEST2 BOOST, compile training validation datasets. From analysed questionnaires 1299 patients, of whom 880 (67·7%) had...
Purpose: Duodenal polyposis and cancer are important causes of morbidity mortality in familial adenomatous (FAP) MUTYH-associated (MAP). This study aimed to comprehensively characterize somatic genetic changes FAP MAP duodenal adenomas better understand tumorigenesis these disorders.Experimental Design: Sixty-nine were biopsied during endoscopy 16 10 patients with polyposis. Ten matched blood DNA samples exome sequenced, 42 further underwent targeted sequencing, 47 studied by array...
The simplified magnetic resonance enterography [MRE] index of activity [sMARIA], London, and 'extended' scoring systems are widely used in Crohn's disease [CD] to assess activity, although validation studies have usually been single-centre, retrospective, and/or few readers. Here, we evaluated these MRE indices within a prospective, multicentre, multireader, diagnostic accuracy trial.A subset participants [newly diagnosed or suspected relapse] recruited the METRIC trial with available...
The host local immune response (LIR) to cancer is a determinant of outcome. Regulation this largely achieved through chemokine synthesis from the tumor microenvironment such as C-Chemokine-Receptor-7 (CCR7). We examined LIR measured CCR7 expression, in colorectal cancers (CRC) and explored relationships with body composition (BC) survival.A study paraffin-embedded tissue specimens was carried out 116 patients non-metastatic CRC. expression determined by immunohistochemistry. Analysis...
Abstract Aneuploidy, the loss and gain of whole part chromosomes, is near-ubiquitous in cancer genomes likely defines cell biology. However, temporal evolutionary dynamics that select for aneuploidy remain uncharacterised. Here we perform longitudinal genomic analysis 755 samples from a total 167 patients with colorectal-derived neoplastic lesions represent distinct stages tumour evolution through metastasis treatment. Adenomas typically had few copy number alterations (CNAs) most were...
Abstract Aim The aim was to determine the presentation, management and outcomes of MUTYH ‐associated polyposis (MAP). Method A prospectively maintained database used identify patients with MAP. Demographic data on germline mutation, surgical management, histopathology tumours endoscopic surveillance were collected. Results In all, 134 MAP identified. majority presented symptomatically ( n = 83). Sixty‐eight developed cancer (seven synchronous, 12 metachronous). median age at diagnosis first...
Dendritic cells (DCs) are antigen-presenting that can acquire tumour antigens and initiate cytotoxic T cell reactions. Obesity has been proposed as a cause for tumours escaping immune surveillance, but few studies investigate the impact of other body composition parameters. We examined relationship DC phenotype with computer tomography (CT)-defined parameters in patients colorectal cancer (CRC). DCs were identified within peripheral blood mononuclear by flow cytometry HLA-DR positive...