A5029670576- Neonatal Respiratory Health Research
- Clinical Nutrition and Gastroenterology
- Respiratory Support and Mechanisms
- Congenital Heart Disease Studies
- Diet and metabolism studies
- Mechanical Circulatory Support Devices
- Gastrointestinal disorders and treatments
- Sepsis Diagnosis and Treatment
- Infant Development and Preterm Care
- Neonatal and Maternal Infections
- Tracheal and airway disorders
- Metabolism and Genetic Disorders
- Nuclear Structure and Function
- Congenital Diaphragmatic Hernia Studies
- Pulmonary Hypertension Research and Treatments
- Coronary Artery Anomalies
- Inflammatory Myopathies and Dermatomyositis
- Immunodeficiency and Autoimmune Disorders
- Cardiac Arrhythmias and Treatments
- Child Nutrition and Feeding Issues
- Airway Management and Intubation Techniques
- Pneumonia and Respiratory Infections
- Blood transfusion and management
- Cholesterol and Lipid Metabolism
- Anesthesia and Neurotoxicity Research
University of Bonn
1990-2019
Centre Hospitalier de Luxembourg
2010-2018
Zentrum für Kinderheilkunde
1993-2007
RWTH Aachen University
2005-2007
Universitätsklinikum Aachen
2005-2006
University Hospital Bonn
1999-2005
Children's Hospital
2004
University of Bayreuth
1999
Universitätskinderklinik
1992-1998
Deutsches Herzzentrum der Charité
1988
Abstract The rate of caesarean section delivery (CSD) is increasing worldwide. It remains unclear whether disruption mother-to-neonate transmission microbiota through CSD occurs and it affects human physiology. Here we perform metagenomic analysis earliest gut microbial community structures functions. We identify differences in encoded functions between microbiomes vaginally delivered (VD) neonates. Several functional pathways are over-represented VD neonates, including lipopolysaccharide...
Perturbations to the colonization process of human gastrointestinal tract have been suggested result in adverse health effects later life. Although much research has performed on bacterial and succession, less is known about other two domains life, archaea, eukaryotes. Here we describe succession by bacteria, archaea microeukaryotes during first year life (samples collected around days 1, 3, 5, 28, 150, 365) within infants delivered either vaginally or cesarean section using a combination...
Abstract Congenital generalized lipodystrophy (CGL) is a rare autosomal recessive disorder characterized by near complete absence of adipose tissue from birth. Recently, mutations in 1-acylglycerol-3-phosphate O-acyltransferase 2 (AGPAT2) and Berardinelli-Seip congenital (BSCL2) genes were reported pedigrees linked to chromosomes 9q34 11q13, respectively. There are limited data regarding phenotypic differences between the various subtypes CGL. Furthermore, whether there additional loci for...
We have previously presented evidence that most of the 24S-hydroxycholesterol present in circulation originates from brain and elimination this oxysterol occurs liver. Plasma levels decline by a factor about 5 during first decades life. The concentration enzyme cholesterol 24S-hydroxylase is, however, constant year life, reduced thus cannot explain decreasing plasma infancy. In work we tested hypothesis may reflect size relative to capacity liver eliminate substance. It is shown here...
Abstract We describe a fatal case of encephalitis that might be correlated with primary human metapneumovirus (HMPV) encephalitis. Postmortem HMPV RNA was detected in brain and lung tissue samples from the patient. Furthermore, found culture fluids cells coincubated tissue.
Aerosolised prostacyclin (PGI2) was administered to two neonates with pulmonary hypertension dilate the vessels selectively. The alveolar-arterial oxygen gradient fell from 73.2 (patient 1) and 71.8 kPa 2) 33.8 26.7 respectively. Systemic blood pressure remained stable while declined in patient 1. When inhaled, PGI2 seems improve oxygenation, mainly due reduction of intrapulmonary shunting.
Objective: The objective of this study was to determine the epidemiology acute respiratory distress syndrome (ARDS) in children and adolescents aged 1 mo 18 yrs. Design: authors conducted a population-based prospective multicenter survey from February 28,1997, June 30, 2001, April 2004. Setting: This at 94 intensive care units (ICUs) 1997, 92 ICUs 2001 2004 district Cologne, Germany with population 4.15 (1997), 4.28 (2001), 4.35 million (2004), respectively. not confined children's...
Parenteral nutrition–associated cholestatic liver disease (PNAC) is considered to be multifactorial in origin, and its incidence has decreased during the past years (1). The pathogenesis of PNAC, however, remains poorly understood.Commercially available intravenous fat emulsions are soy-based preparations containing phytosterols (PS) sitosterol, campesterol, sigmasterol at a total concentration approximately 1000 μmol/L (40 mg/dL). observation high plasma levels PS patients with receiving...
In two patients, a 50-year-old woman (case 1) and 2-year-old girl 2) acute shortness of breath requiring artificial ventilation developed 3-5 hours after infusion erythrocyte concentrates in case 1 unfiltered platelet-enriched plasma (20 ml/kg) 2. The chest radiograph showed diffuse infiltrations the lungs both patients. After administration catecholamines respirator therapy, extubation was possible first patient days, second five days. neither had there been any evidence hypervolaemia,...
A neonate suffering from herpes simplex virus type 2 disease with central nervous system involvement developed an early recurrence under acyclovir therapy. Isolates the cerebrospinal fluid and skin lesions were resistant, while viruses blood trachea not. Acyclovir combined foscavir followed by long-term suppressive therapy supported normal neurological development.
<h3>OBJECTIVE</h3> To compare dual therapy (omeprazole and amoxicillin) with triple (omeprazole, amoxicillin, clarithromycin) in the treatment of<i>Helicobacter pylori</i> infection. The efficacy of 1 mg/kg/day omeprazole was randomly compared 2 mg/kg/day. <h3>STUDY DESIGN</h3> 252 patients (median age, 11.0 years; range, 3–18) presenting chronic abdominal pain underwent endoscopy a <sup>13</sup>C-urea breath test. Gastric biopsy specimens were taken for histological examination rapid urease...
Congenital generalized lipodystrophy (CGL) is characterized by the absence of adipose tissue from birth due to a hypothetical differentiation block. The genetic causes CGL are still not completely understood. Subepidermal, fibroblast-like cells were prepared sc an infant with CGL. Preadipocytes and foreskin fibroblasts three healthy patients, respectively, used as controls. Adipose was induced in cultured exposure 10 nm insulin, 200 pm T3, 1 μm cortisol, 2 rosiglitazone. Under these...
To evaluate the experience with "balloon" gastrostomy buttons in pediatric patients. Distributions of shaft lengths and longevity balloon tubes were examined. Parents' caregivers' opinion about this type tube analysed.Retrospective chart review (n=38) short questionnaire (n=21) during regular follow up visits.The mean was 193 days. 90.7% from 1.5 to 2.3 cm. 100% caregivers evaluated handling button as equal or better (81%) than a conventional PEG tube. "Overall" satisfaction 5% 85%...
Hintergrund, Patienten und Methodik: Von November 1997 bis Mai 1998 wurde am Zentrum für Kinderheilkunde der Universität Bonn in einer prospektiven Surveillance-Studie die Inzidenz nosokomialer Infektionen auf interdisziplinären pädiatrischen Intensivpflege- Überwachungsstation untersucht. Die Erfassung erfolgte nach einem standardisierten Konzept (SEKI), das sich an den Vorgaben des U.S.-amerikanischen National Nosocomial Infections Surveillance [NNIS] Systems Centers for Disease Control...