A5059467905- Gut microbiota and health
- Diet and metabolism studies
- Genomics and Phylogenetic Studies
- Molecular Biology Techniques and Applications
- Microbial Community Ecology and Physiology
- COVID-19 epidemiological studies
- Tryptophan and brain disorders
- Gastric Cancer Management and Outcomes
- Gene expression and cancer classification
- Dementia and Cognitive Impairment Research
- Clostridium difficile and Clostridium perfringens research
- COVID-19 and Mental Health
- Oral health in cancer treatment
- Environmental DNA in Biodiversity Studies
- Enhanced Recovery After Surgery
- Bioinformatics and Genomic Networks
- Diabetes and associated disorders
- Pneumonia and Respiratory Infections
- Bacterial Infections and Vaccines
- Microbial Fuel Cells and Bioremediation
- Nosocomial Infections in ICU
- Neutropenia and Cancer Infections
- Restless Legs Syndrome Research
- Aging, Elder Care, and Social Issues
- Reproductive System and Pregnancy
University of Luxembourg
2013-2024
Centre Hospitalier de Luxembourg
2018
University of Kaiserslautern
2015
Abstract The rate of caesarean section delivery (CSD) is increasing worldwide. It remains unclear whether disruption mother-to-neonate transmission microbiota through CSD occurs and it affects human physiology. Here we perform metagenomic analysis earliest gut microbial community structures functions. We identify differences in encoded functions between microbiomes vaginally delivered (VD) neonates. Several functional pathways are over-represented VD neonates, including lipopolysaccharide...
Existing workflows for the analysis of multi-omic microbiome datasets are lab-specific and often result in sub-optimal data usage. Here we present IMP, a reproducible modular pipeline integrated reference-independent coupled metagenomic metatranscriptomic data. IMP incorporates robust read preprocessing, iterative co-assembly, analyses microbial community structure function, automated binning, as well genomic signature-based visualizations. The IMP-based integration strategy enhances usage,...
BACKGROUND: After the World Health Organization declared outbreak of coronavirus disease to be a public health emergency international concern on January 30, 2020, first SARS-CoV-2 infection was detected in Luxembourg February 29, 2020. Representative population-based data, including asymptomatic individuals for assessing viral spread and immune response were, however, lacking worldwide. METHODS: Using panel-based method, we implemented representative sample Luxembourgish population based...
Infections with SARS-CoV-2 have a pronounced impact on the gastrointestinal tract and its resident microbiome. Clear differences between severe cases of infection healthy individuals been reported, including loss commensal taxa. We aimed to understand if microbiome alterations functional shifts are unique or common effect COVID-19. used high-resolution systematic multi-omic analyses profile gut in asymptomatic-to-moderate COVID-19 compared control group.We found striking increase overall...
Free nitrous acid (FNA) exerts a broad range of antimicrobial effects on bacteria, although susceptibility varies considerably among microorganisms. Among nitrifiers found in activated sludge wastewater treatment processes (WWTPs), nitrite-oxidizing bacteria (NOB) are more susceptible to FNA compared ammonia-oxidizing (AOB). This selective inhibition NOB over AOB WWTPs bypasses nitrate production and improves the efficiency costs nitrogen removal process both anaerobic ammonium oxidation...
Sequencing-based analyses of low-biomass samples are known to be prone misinterpretation due the potential presence contaminating molecules derived from laboratory reagents and environments. DNA contamination has been previously reported, yet with RNA is usually considered very unlikely its inherent instability. Small RNAs (sRNAs) identified in tissues bodily fluids, such as blood plasma, have implications for physiology pathology, therefore act disease biomarkers. Thus, possibility...
Background: With continuously aging societies, an increase in the number of people with cognitive decline is to be expected. Aside from development causative treatments, successful implementation prevention strategies utmost importance reduce high societal burden caused by neurodegenerative diseases leading dementia among which most common cause Alzheimer’s disease. Objective: The aim Luxembourgish “programme (pdp)” prevent or at least delay at-risk population through personalized...
The two-component regulatory system CiaRH of Streptococcus pneumoniae is involved in β-lactam resistance, maintenance cell integrity, bacteriocin production, host colonization, virulence, and competence. response regulator CiaR controls, among other genes, expression five highly similar small non-coding RNAs, designated csRNAs. These csRNAs control competence development by targeting comC, encoding the precursor stimulating peptide, which essential to initiate cascade leading In addition,...
Abstract Background During the COVID-19 pandemic swift implementation of research cohorts was key. While many studies focused exclusively on infected individuals, population based are essential for follow-up SARS-CoV-2 impact public health. Here we present CON-VINCE cohort, estimate point and period prevalence infection, reflect spread within Luxembourgish population, examine immune responses to infection vaccination, ascertain psychological wellbeing at a nationwide level. Methods A...
Self-perceived unmet needs in people with typical and atypical parkinsonism (PwP) their caregivers, support network, personalized ways to address self-perceived during confinement, as well the prevalence of self-reported COVID-19 related symptoms, confirmed SARS-CoV-2 infection, hospitalization Luxembourg Greater Region were assessed. From 18th March 10th April 2020, 679 PwP contacted by phone. Data was collected form a semi-structured interview. The thematic synthesis identified 25 themes...
Abstract We present IMP, an automated pipeline for reproducible integrated analyses of coupled metagenomic and metatranscriptomic data. IMP incorporates preprocessing, iterative co-assembly data, microbial community structure function as well genomic signature-based visualizations. Complementary use data improves assembly quality enables the estimation both population abundance activity while allowing recovery analysis potentially important components, such RNA viruses. is containerized...
ABSTRACT Background Sequencing-based analyses of low-biomass samples are known to be prone misinterpretation due the potential presence contaminating molecules derived from laboratory reagents and environments. Due its inherent instability, contamination with RNA is usually considered unlikely. Results Here we report small (sRNA) contaminants in widely used microRNA extraction kits means for their depletion. Sequencing sRNAs extracted human plasma was performed significant levels non-human...
Abstract BACKGROUND Given that in an increasingly ageing society, the number of people with cognitive impairment is expected to increase, prevention strategies reduce high personal and societal burden neurodegenerative diseases leading dementia essence. METHODS As part “Dementia Prevention Programme (pdp)” Luxembourg, individuals Mild Cognitive Impairment (MCI) or Subjective Decline (SCD) are recruited via referring physicians other sources. All participants undergo a comprehensive...