Deborah McIntyre
A5007624249- Parkinson's Disease Mechanisms and Treatments
- Animal Nutrition and Physiology
- Neurological disorders and treatments
- Counseling, Therapy, and Family Dynamics
- Neurological diseases and metabolism
- RNA regulation and disease
- Vascular Procedures and Complications
- Alcoholism and Thiamine Deficiency
- Healthcare innovation and challenges
- Neurological and metabolic disorders
- Livestock and Poultry Management
- Infectious Encephalopathies and Encephalitis
- Child Therapy and Development
- Meat and Animal Product Quality
- Geriatric Care and Nursing Homes
- Migration, Aging, and Tourism Studies
- Dementia and Cognitive Impairment Research
- Central Venous Catheters and Hemodialysis
- Ginkgo biloba and Cashew Applications
- Restless Legs Syndrome Research
- Homicide, Infanticide, and Child Abuse
- Biochemical and Molecular Research
- Gut microbiota and health
- Bird parasitology and diseases
- Immune responses and vaccinations
Luxembourg Institute of Health
2022-2025
Centre Hospitalier de Luxembourg
2011-2024
Laboratoire National de Santé
2024
University of Luxembourg
2024
Diamond V (United States)
2013-2017
The University of Queensland
2016
Center for Food Safety and Applied Nutrition
2001
United States Food and Drug Administration
2001
West Virginia University
1993
Elwyn
1991
Abnormal α-synuclein aggregation is a key pathological feature of group neurodegenerative diseases known as synucleinopathies, which include Parkinson's disease (PD), dementia with Lewy bodies and multiple system atrophy (MSA). The pathogenic β-sheet seed conformation found in various tissues, suggesting potential biomarker, but few studies have been able to reliably detect these seeds serum samples. In this study, we developed modified assay system, called immunoprecipitation-based...
Abstract Parkinson’s disease (PD) is a highly heterogeneous disorder influenced by several environmental and genetic factors. Effective disease-modifying therapies robust early-stage biomarkers are still lacking, an improved understanding of the molecular changes in PD could help to reveal new diagnostic markers pharmaceutical targets. Here, we report results from cohort-wide blood plasma metabolic profiling patients controls Luxembourg Study detect disease-associated alterations at level...
Abstract Heterozygous variants in the glucocerebrosidase GBA1 gene are an increasingly recognized risk factor for Parkinson’s disease (PD). Due to GBAP1 pseudogene, which shares 96% sequence homology with coding region, accurate variant calling by array-based or short-read sequencing methods remains a major challenge understanding genetic landscape of -associated PD. We analyzed 660 patients PD, 100 Parkinsonism and 808 healthy controls from Luxembourg study, sequenced using amplicon-based...
Background: With continuously aging societies, an increase in the number of people with cognitive decline is to be expected. Aside from development causative treatments, successful implementation prevention strategies utmost importance reduce high societal burden caused by neurodegenerative diseases leading dementia among which most common cause Alzheimer’s disease. Objective: The aim Luxembourgish “programme (pdp)” prevent or at least delay at-risk population through personalized...
Double-blind studies have demonstrated that motor complications in Parkinson's disease (PD) can be reduced with continuous delivery of levodopa. The DopaFuse system is a novel, intraoral micropump attaches to retainer and uses propellant deliver levodopa/carbidopa (LD/CD) continuously into the mouth.
Abstract MicroRNAs act via targeted suppression of messenger RNA translation in the DNA–RNA–protein axis. The dysregulation microRNA(s) reflects epigenetic changes affecting cellular processes multiple disorders. To understand complex effect dysregulated microRNAs linked to neurodegeneration, we performed a cross-sectional microRNA expression analysis idiopathic Parkinson's disease (n = 367), progressive supranuclear palsy 35) and healthy controls 416) from Luxembourg Study, followed by...
Several phenotypic differences observed in Parkinson's disease (PD) patients have been linked to age at onset (AAO). We endeavoured find out whether these are due the ageing process itself by using a combined dataset of idiopathic PD (n = 430) and healthy controls (HC; n 556) excluding carriers known PD-linked genetic mutations both groups. found several significant effects AAO on motor non-motor symptoms PD, but when comparing with HC (using assessment, AAA), only positive associations AAA...
Background Deep phenotyping of Parkinson’s disease (PD) is essential to investigate this fastest-growing neurodegenerative disorder. Since 2015, over 800 individuals with PD and atypical parkinsonism along more than control subjects have been recruited in the frame observational, monocentric, nation-wide, longitudinal-prospective Luxembourg study. Objective To profile baseline dataset explore risk factors, comorbidities clinical profiles associated PD, controls. Methods Epidemiological...
3 Abstract: An experiment was conducted to test the effects of different levels a Saccharomyces cerevisiae fermentation product on performance and gut characteristics male turkeys 18 weeks age. Turkeys were housed in 32 pen facility (800 birds) with eight replicates three (0.0625, 0.125, 0.25%) XPC (Diamond V Mills) compared negative control without XPC. Experimental parameters measured included: body weight, feed intake, conversion, mortality (villi height, crypt depth, section...
Biological supplements in poultry feed are of continued interest due to the improvements growth performance, protection from pathogen invasion, and benefits overall host health. The fermentation metabolites Diamond V Original XPC™ (XPC) have previously been shown improve commercial performance reduce Salmonella poultry. current study sought characterize cecal microbiota using culture-independent analysis based on 16S rRNA gene Coccivac-D sprayed broilers supplemented with XPC and/or...
ABSTRACT This article examines the current theoretical constructions of phenomenon domestic violence, and their therapeutic implications. It attempts to draw out latent socio‐political content that theorizing, arguing throughout various approaches there is a consistent de‐emphasizing woman's position as victim violent act. An alternative analysis offered, one which recognizes gender inequality fundamental any understanding implications for work in this area are briefly explored.
Factors affecting production of Large White turkey hens were examined. Six flocks (n = 136 to 149 per flock) housed at commercial facilities in the United States and two 40 Kingdom (UK). Effects time-in-lay on egg duration clutches pauses determined using all flocks. Also, effects time-in-lay, molt, characteristics individual eggs (size, sequence position, grade, incubational weight loss) fertility, hatchability, embryonic mortality UK Each flock showed a distinctive pattern production; it...
Abstract The authors argue that the phrase "feminist family therapy" suggests a compatibility between two bodies of knowledge and practice-feminism therapy -which they believe has not been adequately articulated. Accordingly, field lacks clear theoretical framework which could yield consistent practice methodology reflective both feminist systemic/cybernetic understandings. While it is yet such integration possible-or even necessarily desirable-the explore possibility Bateson's concept...
In an effort to improve broiler performance in environment with increasing feed costs, researchers have investigated breeder diet modification as a nontraditional way without affecting costs. Broiler of vitamins and minerals has received considerable attention, but feeding hens yeast fermentation products affect progeny is under-researched area. this study, Cobb 500 were allocated floor pens fed mash diets (from 20 wk onward) or Saccharomyces cerevisiae product. Hens artificially inseminated...
Abstract Gut microbiome differences between people with Parkinson’s disease (PD) and control subjects without Parkinsonism are widely reported, but potential alterations related to PD mild cognitive impairment (MCI) have yet be comprehensively explored. We compared gut microbial features of MCI ( n = 58) cognitively unimpaired 60) 90) normal cognition. Our results did not support a specific signature in PD.
Abstract Introduction While there is an interest in defining longitudinal change people with chronic illness like Parkinson’s disease (PD), statistical analysis of data not straightforward for clinical researchers. Here, we aim to demonstrate how the choice method may influence research outcomes, (e.g., progression apathy), specifically size effect estimates, a cohort. Methods In this retrospective 802 typical Luxembourg Parkinson's study, compared mean apathy scores at visit 1 and 8 by...
Abstract Twenty-three laboratories participated in a collaborative study to compare the relative effectiveness of Rappaport-Vassiliadis (RV) medium incubated at 42°C, selenite cystine (SC) broth (35°C), and tetrathionate (TT) (35 43°C) for recovery Salmonella from following foods with low microbial load: dried egg yolk, dry active yeast, ground black pepper, guar gum, instant nonfat milk. For lauryl tryptose (LT) broth, 35°C, was used instead SC broth. All were artificially inoculated single...
An experiment was conducted to compare different strategies for feed formulation in commercial broiler production. Table values the total amino acid (TAA) contents of ingredients are most common source information formulation. Near-infrared reflectance spectroscopy (NIRS) is a tool rapid and cost-effective prediction composition plant animal tissue can be calibrated predict nutrient content ingredients. A 1,400 one-day-old Ross 308 mixed-sex chickens were fed diets formulated 2 feeding...
Purpose: Many adults aged less than 65 years with high-care needs resulting from acquired disabilities are unable to access age-appropriate housing and support, reside in residential care or live family members who may struggle navigate the disability support system. This qualitative study aimed investigate experiences of their regarding pathways related support.Method: Two in-depth semi-structured interviews were conducted six months apart 21 people 18 varying etiology living different...
Abstract Background Parkinson's disease (PD), while often associated with its distinctive motor symptoms, can also exert a notable impact on the cardiovascular system due to development of severe autonomic dysfunction. One initial indicators PD is appearance dysautonomia. As such, it vital monitor and manage health individuals PD, as may have clinical implications in commonly recognized non-motor aspects disease. To study association history (CVD) occurrence severity here, we lend data CVD...
Preferences for risk disclosure in population-based studies assessing Parkinson's disease (PD) have not been assessed so far. To examine preferences a subset of the European Healthy Brain Aging (HeBA) multicenter study. After remote PD assessment, structured pilot-questionnaire on was first presented to participants (≥50 years, without neurodegenerative diseases) during in-person visits at Innsbruck study site. From included 81 (63% females, median age 65 years), 79% expressed an...