A5008658383- Parkinson's Disease Mechanisms and Treatments
- Neurological disorders and treatments
- Neurological diseases and metabolism
- Genetic Neurodegenerative Diseases
- Cerebrovascular and Carotid Artery Diseases
- Ginkgo biloba and Cashew Applications
- Liver Disease Diagnosis and Treatment
- Pancreatic and Hepatic Oncology Research
- Autophagy in Disease and Therapy
- Botulinum Toxin and Related Neurological Disorders
- Epigenetics and DNA Methylation
- EEG and Brain-Computer Interfaces
- Hepatocellular Carcinoma Treatment and Prognosis
- Gastroesophageal reflux and treatments
- Peripheral Neuropathies and Disorders
- Esophageal and GI Pathology
- Transcranial Magnetic Stimulation Studies
- Pituitary Gland Disorders and Treatments
- Autoimmune Neurological Disorders and Treatments
- Amyotrophic Lateral Sclerosis Research
- Intracranial Aneurysms: Treatment and Complications
- Lysosomal Storage Disorders Research
- Metabolism and Genetic Disorders
- Alzheimer's disease research and treatments
- Glycogen Storage Diseases and Myoclonus
Juntendo University
2016-2025
John Wiley & Sons (United States)
2024
Juntendo University Hospital
2023
Fukushima Medical University
2021
Kurume University
1995-2018
Nara Medical University
2005-2017
Juntendo University Urayasu Hospital
2014-2015
Juntendo University Nerima Hospital
2015
Kagoshima University
2011-2013
Kyushu University
2005
Abnormal α-synuclein aggregation is a key pathological feature of group neurodegenerative diseases known as synucleinopathies, which include Parkinson's disease (PD), dementia with Lewy bodies and multiple system atrophy (MSA). The pathogenic β-sheet seed conformation found in various tissues, suggesting potential biomarker, but few studies have been able to reliably detect these seeds serum samples. In this study, we developed modified assay system, called immunoprecipitation-based...
Objective Aging is the highest risk factor for Parkinson disease (PD). Under physiological conditions, spermidine and spermine experimentally enhance longevity via autophagy induction. Accordingly, we evaluated ability of each polyamine metabolite to act as an age‐related, diagnostic, severity‐associated PD biomarker. Methods Comprehensive metabolome analysis plasma was performed in Cohort A (controls, n = 45; PD, 145), followed by 7 metabolites B 49; 186; progressive supranuclear palsy, 19;...
To investigate the kinetics and metabolism of caffeine in serum from patients with Parkinson disease (PD) controls using liquid chromatography-mass spectrometry.Levels its 11 metabolites 108 PD 31 age-matched healthy were examined by spectrometry. Mutations caffeine-associated genes screened direct sequencing.Serum levels 9 downstream significantly decreased even early PD, unrelated to total intake or severity. No significant genetic variations CYP1A2 CYP2E1, encoding cytochrome P450 enzymes...
Purpose To evaluate whether the reduction rate of T1 relaxation time liver (T1 index) before and 20 minutes after gadolinium‐ethoxybenzyl‐diethylenetriaminepentaacetic acid (Gd‐EOB‐DTPA) injection has potential to serve as an magnetic resonance imaging (MRI)‐based function test in comparison with signal intensity‐based indices. Materials Methods Ninety‐nine patients suspected lesions underwent Gd‐EOB‐DTPA‐enhanced MRI. maps using 3D T1‐weighted gradient‐echo volumetric interpolated...
Abstract Objective Parkin is the causative gene for autosomal recessive familial Parkinson's disease ( PD ), although it remains unclear how parkin dysfunction involved with general condition. Recently, serum and/or plasma metabolomics revealed alterations in metabolic pathways that might reflect pathomechanisms of idiopathic iPD ). Thus, we hypothesized patients homozygous or compound heterozygous mutations (namely, PARK 2) due to dysfunction. Methods We enrolled 15 2 (52 ± 17.6 years)...
Abstract Continuous, objective monitoring of motor signs and symptoms may help improve tracking disease progression treatment response in Parkinson’s (PD). This study assessed the analytical clinical validity multi-sensor smartwatch measurements hospitalized home-based settings (96 patients with PD; mean wear time 19 h/day) using a twice-daily virtual examination (VME) at times representing medication OFF/ON states. Digital measurement performance was better during inpatient assessments for...
Myelin-oligodendrocyte glycoprotein antibody (MOG antibodies) was found in various demyelinated diseases. This is the first report of a patient with longitudinally extensive transverse myelitis an extremely high titer MOG antibodies after influenza infection. case supports view that are linked to and infection might trigger antibodies.A 32-year-old healthy male developed fever, dysesthesia paraesthesia below C2 area, muscle weakness bilateral lower extremities, urinary retention ten days...
Recently, the role of T cells in pathology α-synuclein (αS)-mediated neurodegenerative disorders called synucleinopathies, including Parkinson's disease (PD), dementia with Lewy bodies (DLB), and multiple system atrophy, has attracted increasing attention. Although existence αS-specific immunogenicity post-translationally modified αS fragment have been reported PD DLB, key cellular subset associated progression its induction mechanism remain largely unknown. Peripheral blood mononuclear...
Abstract Objective To investigate the oxidized albumin ratio, which is redox ratio of human nonmercaptalbumin (HNA) to serum (%HNA), as a biomarker in idiopathic Parkinson’s disease (iPD) and related neurodegenerative disorders. Methods This prospective study enrolled 216 iPD patients, 15 patients with autosomal recessive familial PD due parkin mutations (PARK2), 30 multiple system atrophy (MSA) 32 progressive nuclear palsy (PSP) 143 healthy controls. HNA was analyzed using modified...
Abstract Parkinson's disease (PD) is a progressive neurodegenerative presenting with motor and non-motor symptoms, including skin disorders (seborrheic dermatitis, bullous pemphigoid, rosacea), pathological changes (decreased nerve endings alpha-synuclein deposition), metabolic of sebum. Recently, transcriptome method using RNA in surface lipids (SSL-RNAs) which can be obtained non-invasively an oil-blotting film was reported as novel analytic Here we report analyses SSL-RNAs the potential...
The objective of this study was to determine comprehensive metabolic changes caffeine in the serum patients with parkinsonian disorders including Parkinson's disease (PD), progressive supranuclear palsy (PSP), and multiple system atrophy (MSA) compare healthy control serum.Serum levels its 11 downstream metabolites from independent double cohorts consisting PD (n = 111, 160), PSP 30, 19), MSA 23, 17), controls 43, 31) were examined by liquid chromatography-mass spectrometry. association each...
Abstract Parkinson’s disease, the second most common neurodegenerative disorder, is characterized by loss of nigrostriatal dopamine neurons. FBXO7 (F-box protein only 7) (PARK15) mutations cause early-onset disease. a subunit SCF (SKP1/cullin-1/F-box protein) E3 ubiquitin ligase complex, but its neuronal relevance and function have not been elucidated. To determine in neurons, we generated cell-specific conditional knockout mice (FBXO7 flox/flox : Nestin-Cre) crossing previously floxed )...
Abstract Background Chronic constipation is a common digestive complication of Parkinson's disease (PD). Objectives To verify the usefulness elobixibat, an ileal bile acid transporter inhibitor, for chronic in PD. Methods This double‐blind, placebo‐controlled study consisted 2‐week observation/washout period and 4‐week treatment period. All patients received Bowel Movement Diary at Week ‐2 were allocated to elobixibat (10 mg) or placebo 0. Patients visited Weeks 2 4 report daily spontaneous...
Hypothyroidism is one of the most important causes treatable dementia, and psychosis occasionally associated with it known as myxedema madness. We report a case 90-year-old patient who developed madness acutely without overt clinical symptoms signs suggestive hypothyroidism. A Japanese man, general practitioner, was admitted to our emergency room because acute-onset lethargy, delusions, hallucinations. He had been actively working until 3 days before admission. Upon admission, his physical...
Immunodeficiency with a thymoma (Good's syndrome) is rare condition occurring in patients adult-onset hypogammaglobulinemia that progressive after the removal of thymoma. Recently, we encountered patient Good's syndrome who suddenly developed opportunistic encephalitis 4 years resection without history infectious complications.A 58-year-old man, underwent surgery to remove at age 54, was admitted because speech difficulties. A brain MRI showed multiple lesions involving frontal lobes, but...
Progressive encephalomyelitis with rigidity and myoclonus (PERM) is a rare disease. PERM consists of the same symptoms as stiff person syndrome, in addition to sensory, brainstem autonomic features. We herein report case 48-year-old woman who initially presented spasticity lower limbs subsequently developed upper limb spasticity, perioral restlessness after three months. The onset potentially fatal dysautonomia was observed at peak Treatment high-dose immunoglobulin (400 mg/kg, 5 days),...
Objective Parkinson's disease (PD) is a common neurodegenerative characterized by initial involvement of the olfactory bulb/amygdala or autonomic nerves followed nigral degeneration. Although innervation strictly regulates multiorgan systems, including endocrine functions, circulation, and digestion, how dysautonomia in PD affects systemic metabolism has not been identified. In this study, we tried to estimate pathogenic linkage nuclear medicine techniques, trans‐omic analysis blood samples,...
Radiological biomarkers have been reported for multiple system atrophy and progressive supranuclear palsy, but serum/plasma each disorder not established. In this context, we performed a pilot study to identify disease-specific plasma palsy. Plasma samples collected from 20 palsy patients, 16 patients controls were investigated by comprehensive metabolome analysis using capillary electrophoresis mass spectrometry liquid chromatography spectrometry. Medication data obtained with correlations...
In super-aged societies, dementia has become a critical issue, underscoring the urgent need for tools to assess cognitive status effectively in various sectors, including financial and business settings. Facial speech features have been tried as cost-effective biomarkers of Alzheimer's disease (AD). We aimed establish an easy, automatic, extensive screening tool AD using chatbot artificial intelligence. Smile images visual auditory data natural conversations with from 99 healthy controls...