A5081227488- Obesity, Physical Activity, Diet
- Growth Hormone and Insulin-like Growth Factors
- Children's Physical and Motor Development
- Estrogen and related hormone effects
- Sexual Differentiation and Disorders
- Adipose Tissue and Metabolism
- Cardiovascular Disease and Adiposity
- Vitamin D Research Studies
- Child and Adolescent Health
- Obesity and Health Practices
- Genetic Syndromes and Imprinting
- Diabetes and associated disorders
- Retinoids in leukemia and cellular processes
- Diabetes Management and Research
- Childhood Cancer Survivors' Quality of Life
- Cardiovascular and exercise physiology
- Cancer, Hypoxia, and Metabolism
- Neuroblastoma Research and Treatments
- Metabolism, Diabetes, and Cancer
- Biotin and Related Studies
- Muscle Physiology and Disorders
- Cardiovascular Function and Risk Factors
- Bone health and osteoporosis research
- Diet and metabolism studies
- Genetics and Neurodevelopmental Disorders
Nepean Hospital
2019-2024
The University of Sydney
2019-2024
Mater Children's Hospital
2007-2024
Queensland Children’s Hospital
2015-2024
University of Macau
2024
The University of Queensland
2010-2023
UNSW Sydney
2023
California State University, Dominguez Hills
2017
Wesley Hospital
2016
University of Illinois Chicago
2016
Disorders of sex development (DSD) are congenital conditions in which chromosomal, gonadal, or phenotypic is atypical. Clinical management DSD often difficult and currently only 13% patients receive an accurate clinical genetic diagnosis. To address this we have developed a massively parallel sequencing targeted gene panel allows us to sequence all 64 known diagnostic genes candidate simultaneously. We analyzed DNA from the largest reported international cohort with (278 46,XY 48 46,XX DSD)....
Oral estrogen administration attenuates the metabolic action of growth hormone (GH) in humans. To investigate mechanism involved, we studied effects on GH signaling through Janus kinase (JAK)2 and signal transducers activators transcription (STATs) HEK293 cells stably expressing receptor (293GHR), HuH7 (hepatoma) T-47D (breast cancer) cells. 293GHR were transiently transfected with an receptor-α expression plasmid luciferase reporters binding elements for STAT3 STAT5 or β-casein promoter....
Abstract Caveolin-1 (CAV1) is a structural protein of caveolae involved in lipid homeostasis and endocytosis. Using newly generated pure Balb/C CAV1 null (Balb/CCAV1−/−) mice, CAV1−/− mice from Jackson Laboratories (JAXCAV1−/−), developed the Kurzchalia Laboratory (KCAV1−/−), we show that under physiological conditions expression mouse tissues necessary to guarantee an efficient progression liver regeneration survival after partial hepatectomy. Absence compensated by development...
Actin has an ill‐defined role in the trafficking of GLUT4 glucose transporter vesicles to plasma membrane ( PM ). We have identified novel actin filaments defined by tropomyosin Tpm3.1 at uptake sites white adipose tissue WAT ) and skeletal muscle. In Tpm 3.1‐overexpressing mice, insulin‐stimulated was increased; while Tpm3.1‐null mice they were more sensitive impact high‐fat diet on uptake. Inhibition function 3T3‐L1 adipocytes abrogates translocation , amount filamentous is determined...
1,25-Dihydroxyvitamin D3(vitamin D) and transforming growth factor-β (TGF-β) regulate diverse biological processes including cell proliferation differentiation through modulation of the expression target genes. Members Smad family proteins function as effectors TGF-β signaling pathways whereas vitamin D receptor (VDR) confers signaling. We investigated molecular mechanisms by which interact in regulation human osteocalcin promoter. Synergistic activation gene promoter was observed transient...
Transforming growth factor-β (TGF-β) signaling requires the action of Smad proteins in association with other DNA-binding factors and coactivator corepressor to modulate target gene transcription. Smad2 Smad3 both associate c-Ski Sno oncoproteins repress transcription genes via recruitment a nuclear complex. Ski-interacting protein (SKIP), hormone receptor coactivator, was examined as possible modulator transcriptional regulation TGF-β-responsive promoter from plasminogen activator inhibitor...
Suppressors of cytokine signaling (SOCS) are important negative regulators action. We recently reported that estrogen stimulates SOCS-2 expression and inhibits GH in kidney cells. The effects on SOCS other tissues unclear. aim this study was to investigate vivo vitro whether affected the liver, a major target organ GH. hepatic ovariectomized mice lacking receptor (ER)-alpha, ERbeta, or both their wild-type littermates were examined by DNA microarray analysis. In vitro, human hepatoma cells...
The long-term effects on bone and fat mass in children with endogenous CS are unknown. In 14 followed for 3-7 years into young adulthood after cure of CS, whereas largely recovered, persisting increases total body visceral suggests an increase risk the metabolic syndrome.Endogenous Cushing syndrome (CS) is associated decreased increased central mass. Whereas seems to improve successful treatment, little known about whether persists.This was a prospective study (10 girls 4 boys) adolescents...
Differences in fundamental movement skills and self-perceptions of physical ability appearance overweight non-overweight children were investigated.Overweight (n = 89, mean age 8.75 ± 1.4 years, BMI z-score 2.22, SD 0.46, 46% male) 27, 8.25 1.5 0.03, 0.73, 62.1% participants enrolled the KOALA (Kinder Overweight Activity Lifestyle Actions) project included. The overall objective was to determine a randomized controlled trial effect Triple P (Positive Parenting Program), family 'Eat Well Be...
Summary Objective We examined parental and early‐life variables in order to identify risk factors for adulthood overweight obesity offspring. report here on the longitudinal prevalence of Australian children born between 1989 1991 followed from birth age 22. Methods Data were analysed 1355 participants Western Pregnancy Cohort (Raine) Study, with anthropometry collected during pregnancy, at birth, one year three yearly intervals thereafter. Multivariate analyses cross‐sectional logistic...
Introduction The prevalence of paediatric obesity is increasing, and with it, lifestyle-related diseases in children adolescents. High-intensity interval training (HIIT) has recently been explored as an alternate to traditional moderate-intensity continuous (MICT) adults chronic disease shown induce a rapid reversal subclinical markers obese primary aim this study compare the effects HIIT MICT on myocardial function Methods analysis Multicentre randomised controlled trial 100 adolescents...
As endogenous Cushing's syndrome (CS) in children occurs during a critical developmental period, when the majority of peak bone mass is acquired, we hypothesized that with CS might be at an increased risk osteoporosis. To determine effects on density, metabolism, and growth, studied 15-yr-old female identical twin pair, one whom had (twin A), other was healthy B). Before therapy for CS, A showed severe loss mineral density [BMD; -3.2SD lumbar spine (LS)] compared to B (-0.1 SD), which...