A5060665424- Estrogen and related hormone effects
- Hormonal Regulation and Hypertension
- Adrenal Hormones and Disorders
- Cytokine Signaling Pathways and Interactions
- Stress Responses and Cortisol
- HIV Research and Treatment
- Circadian rhythm and melatonin
- RNA Research and Splicing
- HIV-related health complications and treatments
- Immune Response and Inflammation
- Reproductive System and Pregnancy
- interferon and immune responses
- HIV/AIDS drug development and treatment
- Pregnancy and preeclampsia studies
- Ubiquitin and proteasome pathways
- Growth Hormone and Insulin-like Growth Factors
- Immune Cell Function and Interaction
- Cancer-related molecular mechanisms research
- Adenosine and Purinergic Signaling
- Peroxisome Proliferator-Activated Receptors
- NF-κB Signaling Pathways
- Preterm Birth and Chorioamnionitis
- Adipose Tissue and Metabolism
- Genetic Syndromes and Imprinting
- 14-3-3 protein interactions
Qatar Airways (Qatar)
2015-2025
Sidra Medical and Research Center
2000-2023
National Institutes of Health
2008-2017
Eunice Kennedy Shriver National Institute of Child Health and Human Development
2008-2017
Research for Action
2010-2014
Pontificia Universidad Católica de Chile
2012
Erasmus University Rotterdam
2012
Erasmus MC
2012
Radboud University Nijmegen
2012
Radboud University Medical Center
2012
The availability of nutrients influences cellular growth and survival by affecting gene transcription. Glucocorticoids also influence transcription have diverse activities on cell growth, energy expenditure, survival. We found that the arrest-specific 5 (Gas5) noncoding RNA, which is abundant in cells whose has been arrested because lack or factors, sensitized to apoptosis suppressing glucocorticoid-mediated induction several responsive genes, including one encoding inhibitor 2. Gas5 bound...
Glucocorticoids, end products of the hypothalamic-pituitary-adrenal axis, influence functions virtually all organs and tissues through glucocorticoid receptor (GR). Circulating levels glucocorticoids fluctuate naturally in a circadian fashion regulate transcriptional activity GR target tissues. The basic helix-loop-helix protein CLOCK, histone acetyltransferase (HAT), its heterodimer partner BMAL1 are self-oscillating transcription factors that generate rhythms both central nervous system...
Adenosine (ADO) exerts potent anti-inflammatory and immunosuppressive effects. In this paper we address the possibility that these effects are partly mediated by inhibition of secretion IL-12, a proinflammatory cytokine major inducer Th1 responses. We demonstrate 5'-N-ethylcarboxamidoadenosine (NECA), nonspecific ADO analogue, 2-p-(2-carbonyl-ethyl)phenylethylamino-5'-N-ethylcarboxamidoadenos ine (CGS-21680), specific A2a receptor agonist, dose-dependently inhibited, in whole blood ex vivo...
The HIV-1 virion-associated accessory protein Vpr affects both viral replication and cellular transcription, proliferation, differentiation. We report that enhances the activity of glucocorticoids in lymphoid muscle-derived cell lines by interacting directly with glucocorticoid receptor general transcription factors, acting as a coactivator. contains signature motif LXXLL also present nuclear coactivators, such steroid coactivator 1 p300/CREB-binding protein, which mediates their interaction...
Context and Objective Circulating cortisol fluctuates diurnally under the control of “master” circadian CLOCK, while peripheral “slave” counterpart latter regulates transcriptional activity glucocorticoid receptor (GR) at local target tissues through acetylation. In this manuscript, we studied effect CLOCK-mediated GR acetylation on sensitivity to glucocorticoids in humans. Design Participants We examined mRNA expression GR, CLOCK-related glucocorticoid-responsive genes blood mononuclear...
Abstract Context: Aldosterone production in the adrenal zona glomerulosa is mainly regulated by angiotensin II, [K+], and ACTH. Genetic deletion of subunits K+-selective leak (KCNK) channels TWIK-related acid sensitive K+-1 and/or K+-3 mice results primary hyperaldosteronism, whereas mutations KCNJ5 (potassium inwardly rectifying channel, subfamily J, member 5) gene are implicated hyperaldosteronism and, certain cases, autonomous cell proliferation humans. Objective: The objective study was...
Glucocorticoids have strong regulatory actions on the immune system and act as potent therapeutic compounds for autoimmune inflammatory diseases. We previously reported that long noncoding RNA growth arrest-specific 5 (Gas5), which accumulates inside cells in response to cellular starvation/growth arrest, functions a repressor of glucocorticoid receptor (GR) through its "glucocorticoid element (GRE)". To evaluate potential roles Gas5 immune-related disorders, we examined levels various...
Multidrug antiretroviral regimens that include human immunodeficiency virus-1 (HIV-1) protease inhibitors are associated with distinct lipodystrophy, hypertriglyceridemia, hyperinsulinemia, and deposition of visceral abdominal adipose tissue. To determine whether these findings related to abnormalities adrenal function, we compared the hypothalamic-pituitary-adrenal axes HIV-positive patients who had evidence inhibitor-associated lipodystrophy (PIAL), control volunteers (CON), Cushing's...