A5032592276- Cystic Fibrosis Research Advances
- Thyroid Cancer Diagnosis and Treatment
- COVID-19 Clinical Research Studies
- Pelvic floor disorders treatments
- Cardiac electrophysiology and arrhythmias
- Diabetes and associated disorders
- ECG Monitoring and Analysis
- Diabetes Management and Research
- Neonatal Respiratory Health Research
- Pancreatic function and diabetes
- Cardiac pacing and defibrillation studies
- Tracheal and airway disorders
- Long-Term Effects of COVID-19
- Thyroid and Parathyroid Surgery
- Thyroid Disorders and Treatments
- Ovarian function and disorders
- Endometriosis Research and Treatment
- Retinal Diseases and Treatments
- Neuroendocrine Tumor Research Advances
- Radiopharmaceutical Chemistry and Applications
- Glaucoma and retinal disorders
- Diverticular Disease and Complications
- Esophageal and GI Pathology
- Ocular Surface and Contact Lens
- Diabetes, Cardiovascular Risks, and Lipoproteins
Sapienza University of Rome
2015-2025
Cystic Fibrosis Research Foundation
2020-2024
Maria Cecilia Hospital
2020-2024
Fondazione Italiana Fegato
2020-2024
Agostino Gemelli University Polyclinic
2022-2024
Università Cattolica del Sacro Cuore
2007-2022
CTO Andrea Alesini
2022
Federico II University Hospital
2017-2021
Azienda Ospedaliera Sant'Andrea
2021
A.P. Giannini Foundation
2021
Background: Gastrointestinal disorders are frequent in COVID-19 and SARS-CoV-2 has been hypothesized to impact on host microbial flora gut inflammation, infecting intestinal epithelial cells. Since there currently no coded therapies or guidelines for treatment of COVID-19, this study aimed evaluate the possible role a specific oral bacteriotherapy as complementary therapeutic strategy avoid progression COVID-19. Methods: We provide report 70 patients positive hospitalized between March 9th...
Ultrasound-guided radiofrequency ablation (RFA) of solid thyroid nodules (TNs) is a minimally invasive procedure that may induce volume reduction symptomatic benign TNs.The aim the study was to evaluate effectiveness and safety RFA in debulking TNs.Eighty-four consecutive patients with cytologically were randomly assigned either single session (group A; n = 42) or follow-up B; at our center. Entry criteria nodule predominantly (with fluid component ≤ 30% volume), normal function, no...
Abstract Background Cardiometabolic disorders may worsen Covid-19 outcomes. We investigated features and outcomes for patients with or without diabetes, cardiometabolic multimorbidity. Methods collected compared data retrospectively from hospitalized multimorbidity (defined as ≥ two of three risk factors hypertension dyslipidaemia). Multivariate logistic regression was used to assess the primary composite outcome (any mechanical ventilation, admission an intensive care unit [ICU] death) in...
The aim of this study was to assess fecal microbiota and metabolome in a population with symptomatic uncomplicated diverticular disease (SUDD).Whether intestinal metabolic profiling may be altered patients SUDD is unknown.Stool samples from 44 consecutive women [15 SUDD, 13 asymptomatic diverticulosis (AD), 16 healthy controls (HCs)] were analyzed. Real-time polymerase chain reaction used quantify targeted microorganisms. High-resolution proton nuclear magnetic resonance spectroscopy...
Latent autoimmune diabetes in adults (LADA) includes a heterogeneous population wherein, based on glutamic acid decarboxylase antibody (GADA) titer, different subgroups of subjects can be identified. The aim the present study was to evaluate GADA titer-related risk for β-cell and other organ-specific autoimmunity LADA subjects. Adult-onset (n = 236) type 2 (T2DM) 450) were characterized protein tyrosine phosphatase (IA-2IC IA-2256–760), zinc transporter 8 (ZnT8), thyroid peroxidase, (TPO),...
Objective The aim of this study was to determine whether glutamic acid decarboxylase antibody (GADA) titer and other clinical parameters could define the risk progression insulin therapy in latent autoimmune diabetes adults (LADA) patients during a 7-year follow-up. Methods This involved 220 LADA 430 type 2 subjects followed up for 7 years from time GADA screening evaluate their toward therapy. Kaplan–Meier curves multivariate logistic regression analysis were performed identify markers...
No defined pre-treatment factors are able to predict the response radiofrequency ablation (RFA) of an autonomously functioning thyroid nodule (AFTN).Primary endpoint was evaluate success rate RFA restore euthyroidism in a cohort adult patients with small solitary AFTN compared medium-sized nodules. Secondary endpoints included volume reduction and conversion from hot nodules cold using scintiscan.This 24-month prospective monocentric open parallel-group trial. Twenty-nine were divided into...
Background: No direct prospective studies comparing laser ablation (LA) and radiofrequency (RFA) for debulking benign non-functioning thyroid nodules (BNTNs) exist. We aimed at the efficacy safety of both techniques in patients with solid or predominantly BNTN. Methods: This six-month, single-use, randomized, open-label, parallel trial compared following primary endpoints between RFA LA groups six months after treatment: (i) nodule volume reduction expressed as a percentage baseline; (ii)...
Selenium is frequently in nutraceuticals for pregnancy, given its role on fertility and thyroid metabolism. However, most evidence rise from non-controlled studies. We aimed to evaluate the protective effect of selenium against autoimmunity during after pregnancy. A multicenter, randomized, double-blind, placebo-controlled trial was performed promoted by Young Italian Endocrinologists Group (EnGioI)—Italian Society Endocrinology. Forty-five women with thyroiditis pregnancy were enrolled...
To compare the number of eye surgical procedures performed in Italy 2 months following beginning lockdown (study period) because COVID-19 epidemic with those two earlier same year (intra-year control) and period 2019 corresponding to (inter-year control).Retrospective analysis carried out at 39 Academic hospitals. A distinction was made between elective urgent procedures. Intravitreal injections were also considered. Percentages for all incidence rate ratios (IRR) rhegmatogenous retinal...
Diabetic foot infections (DFIs) represent one of the most frequent and disabling morbidities longstanding diabetes; therefore, early diagnosis is mandatory. The aim this multicenter retrospective study was to compare diagnostic accuracy white blood cell scintigraphy (WBC), 18F-fluorodeoxyglucose positron emission tomography/computed tomography ((18F) FDG PET/CT), Magnetic Resonance Imaging (MRI) in patients with suspected DFI. Images clinical data from 251 enrolled by five centers were...
Abstract Purpose Bone formation is impaired in both type 1 diabetes and 2 (T2D), whereas sclerostin, an antagonist of bone formation, increased T2D only. No data are available on latent autoimmune adults (LADA), that may clinically resemble at diagnosis. We evaluated serum sclerostin turnover markers LADA compared with those whether metabolic syndrome (MetS) affects or LADA. Methods This cross-sectional study included 98 patients 89 from the Action Non Insulin Requiring Autoimmune Diabetes...
Italian cystic fibrosis registry (ICFR) collects data from (CF) patients through the collaboration with CF referral and support Centres (Italian law 548/93). ICFR contributes: • to analysis of medium long term clinical epidemiological trends disease; identification main health care needs at regional national level contribute Health Care programmes distribution resources; comparison international ones. This latter is based on European and, due COVID-19 pandemic emergency, important global...
Introduction: Thyroidectomy followed by radioactive iodine therapy (RAI) is the treatment of choice for differentiated thyroid carcinoma (DTC). Serum thyroglobulin (Tg) measurement has proved to be useful predicting persistent and/or recurrent disease during follow-up DTC patients. In our study, we evaluated risk recurrence in patients with papillary (PTC), who were treated thyroidectomy and RAI, measuring serum Tg at different time-points: least 40 days after surgery, euthyroidism TSH <...
Artificial tear substitutes are key elements in the first-line treatment of dry eye disease (DED). We hypothesized that GlicoPro®, a new multimolecular complex based on proteins, sulfured and unsulfured glycosaminoglycans opiorphin, was able to significantly improve effect hydroxypropyl-methylcellulose (HPMC) eyedrops treating DED. performed an vitro experiment clinical study, comparing HPMC + GlicoPro®-based HPMC-based ophthalmic formulation (similar kinematic viscosity comparable...
Since December 2019, with the spreading of pandemic, a lot medical centers registered data about their patients. In Italy, most relevant quantity patients was hospitalized in internal medicine wards. this observational, retrospective cross-sectional study, all COVID-19 admitted to some Lazio hospitals from March 01 31, 2020, were collected, and epidemiological data, demographics, signs symptoms on admission, comorbidities, laboratory findings, chest radiography computed tomography treatment...
OBJECTIVE Since patients with type 2 diabetes and positive for 1 diabetes–specific antibodies have wide variations in BMI, this study evaluated whether the frequency pattern of islet autoantibody positivity is related to BMI. RESEARCH DESIGN AND METHODS Clinical biochemical characteristics autoantibodies including GAD protein tyrosine phosphatases antigen-2 (IA-2)IC IA-2(256–760) were 1,850 from Non–Insulin Requiring Autoimmune Diabetes cohort. BMI was all patients, who then subdivided three...