A5021969681- HIV Research and Treatment
- HIV-related health complications and treatments
- Immune Cell Function and Interaction
- COVID-19 Clinical Research Studies
- Infectious Diseases and Tuberculosis
- HIV/AIDS drug development and treatment
- Tuberculosis Research and Epidemiology
- Antibiotic Use and Resistance
- Antibiotics Pharmacokinetics and Efficacy
- Cytomegalovirus and herpesvirus research
- Antibiotic Resistance in Bacteria
- Polyomavirus and related diseases
- Infectious Disease Case Reports and Treatments
- COVID-19 and healthcare impacts
- Pneumocystis jirovecii pneumonia detection and treatment
- Bacterial Infections and Vaccines
- Bone Metabolism and Diseases
- HIV/AIDS Research and Interventions
- Systemic Lupus Erythematosus Research
- Syphilis Diagnosis and Treatment
- Long-Term Effects of COVID-19
- SARS-CoV-2 and COVID-19 Research
- Intraperitoneal and Appendiceal Malignancies
- Plant Virus Research Studies
- Hereditary Neurological Disorders
Sapienza University of Rome
2013-2024
Policlinico Umberto I
1996-2021
Istituto Superiore di Sanità
2021
The University of Texas Medical Branch at Galveston
2019
Istituto Pasteur
2011-2016
Ministero della Salute
2002
University Hospital of Lausanne
2000
University of Lausanne
2000
Abstract Background Cardiometabolic disorders may worsen Covid-19 outcomes. We investigated features and outcomes for patients with or without diabetes, cardiometabolic multimorbidity. Methods collected compared data retrospectively from hospitalized multimorbidity (defined as ≥ two of three risk factors hypertension dyslipidaemia). Multivariate logistic regression was used to assess the primary composite outcome (any mechanical ventilation, admission an intensive care unit [ICU] death) in...
Available therapeutic options against carbapenem-resistant Klebsiella pneumoniae (CR-Kp) are limited because of the high level resistance to other antimicrobial classes including polymyxins. The double-carbapenem regimen has been recently considered a possible strategy. In present study, we evaluated in vitro bactericidal and synergistic activity consisting ertapenem plus high-dose meropenem series patients with healthcare-associated CR-Kp infections whom use colistin was not indicated...
Abstract Background Patients with coronavirus disease 2019 (Covid-19) may experience venous thrombosis while data regarding arterial are sparse. Methods Prospective multicenter study in 5 hospitals including 373 patients Covid-19-related pneumonia. Demographic data, laboratory findings coagulation tests and comorbidities were reported. During the follow-up any or thrombotic events death registered. Results Among patients, 75 (20%) had a event died. Thrombotic included 41 thromboembolism 34...
We evaluated the in vitro activity of different antimicrobial combinations with and without colistin against 39 carbapenem-resistant Klebsiella pneumoniae (CR-Kp) strains (colistin + meropenem/doripenem, tigecycline, rifampicin, gentamicin meropenem, tigecycline double-carbapenem regimen meropenem ertapenem) using chequerboard method. The triple combination was also tested. In addition, killing studies were performed for ertapenem.Gentamicin-based showed a high level synergy. Meropenem...
To investigate the immunological and virological interactions between interleukin (IL)-15 HIV in antiretroviral-naive highly active antiretroviral therapy (HAART)-treated patients.Three groups of HIV-infected patients were studied: 20 untreated with advanced disease; eight viral suppression response to HAART; 10 treatment failure. Eleven healthy blood donors included as controls.The following parameters evaluated: production IL-15 by peripheral mononuclear cells (PBMC) stimulated...
Background Dysregulation of host immune responses plays a critical role in the pathogenesis severe 2009 pandemic H1N1 infection. Whether virus could escape innate defense vivo remains to be investigated. The aim this study was evaluate pattern response during human We performed enumeration circulating myeloid dendritic cells (mDC) and plasmacytoid DC (pDC) blood from patients with pneumonia shortly after onset symptoms follow-up at different intervals time. analysis CD4 CD8 count, CD38...
SUMMARY The concentrations of the chemokines IL-8, monocyte chemotactic protein-1 (MCP-1) and macrophage inflammatory protein-1α (MIP-1α) were measured in 120 CSF samples from 23 patients with pyogenic meningitis 11 tuberculous (TBM) 10 subjects non-infectious neurological diseases. chemokine significantly higher than control (P < 0.0001). highest levels found for IL-8 (median 2917 pg/ml) MCP-1 2557 pg/ml), whereas those MIP-1α less elevated 24 Patients had TBM In serial declined...
To investigate whether antiretroviral therapy (ART) influences the release of matrix metalloproteinase (MMP)-9 from peripheral blood mononuclear cells (PBMC) HIV-infected individuals.Culture supernatants were collected PBMC isolated 46 subjects and 19 healthy donors (HD). Among subjects, 30 receiving ART therapy, while 16 naive for any treatment.Zymography culture was followed by determination MMP-9 using computered scanning densitometry. net enzymatic activity determined sensitive...
The anti-CD49d monoclonal antibody natalizumab is currently an effective therapy against the relapsing-remitting form of multiple sclerosis (RRMS). Natalizumab therapeutic efficacy limited by reactivation John Cunningham polyomavirus (JCV) and development progressive multifocal leukoencephalopathy (PML). To correlate natalizumab-induced phenotypic modifications peripheral blood T-lymphocytes with JCV reactivation, JCV-specific antibodies (serum), JCV-DNA (blood urine), CD49d expression...
HIV-infected patients have a significantly greater risk of cardiovascular disease. Several markers including osteoprotegerin been shown to be involved in the development and progression atherosclerosis. We investigated relationship between T-cell phenotype, osteoprotegerin, atherosclerosis evaluated by carotid intima-media thickness (c-IMT) 94 HIV+ on suppressive antiretroviral therapy with Framingham score <10%. As for control group, 24 HIV-negative subjects were enrolled. c-IMT was...
Polymorphonuclear leukocytes (PMNL) from human immunodeficiency virus (HIV)—infected patients exhibit accelerated apoptosis and impaired functional activity. HIV protease inhibitor—based therapy produces improvements in both acquired innate immune responses. Ex vivo vitro effects of inhibitors on chemotaxis PMNL were evaluated. After therapy, there was a rapid significant decrease apoptosis, which correlated with increased chemotactic function. These findings found immunological virological...
John Cunningham virus (JCV), the etiological agent of progressive multifocal leukoencephalopathy (PML), contains a hyper-variable non-coding control region usually detected in urine healthy individuals as archetype form and brain cerebrospinal fluid (CSF) PML patients rearranged form. We report case HIV-related with clinical, immunological virological data longitudinally collected. On admission (t0), after 8-week treatment rescue highly active antiretroviral therapy (HAART), patient showed...
HIV-infected patients appear to have a significantly greater risk of non-AIDS comorbidities such as osteoporosis and atherosclerosis. Subjects with are at higher developing cardiovascular disease than those normal bone mass, therefore possible relation between these two conditions can be hypothesized. In the setting HIV infection, several factors might contribute endothelial dysfunction. The aim our study was evaluate relationship investigate role traditional factors, T-cell phenotype...
Cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC) showed promising results in selected patients. High morbidity restrains its wide application. The aim of this study was to report postoperative infectious complications investigate possible correlations with the preoperative nutritional status other prognostic factors patients peritoneal metastases treated CRS HIPEC. For study, we reviewed clinical records all from different primary cancers HIPEC our...
Interleukin (IL)-7 is a critical cytokine regulating T-lymphocyte development, regeneration, and function. Purpose: This study analyzes the endogenous IL-7 production in HIV-infected patients receiving highly active antiretroviral treatment (HAART). Method: Plasma levels of were measured by enzyme-linked immunosorbent assay (ELISA) 11 with untreated advanced HIV disease, 8 who successfully responded to HAART, 9 individuals virological immunological failure. Results: We found that disease no...
The aim of the study was to investigate changes matrix metalloproteinase (MMP)-2 and MMP-9 plasma levels during natalizumab treatment their correlation with JC virus (JCV) reactivation T-lymphocyte phenotypic modifications in peripheral blood samples from 34 relapsing-remitting multiple sclerosis (RRMS) patients. were assessed by zymography samples. JCV-DNA detected through quantitative real time PCR phenotype flow cytometry. resulted increased 12 24 infusions. Stratifying according...