A5047292283- Cardiovascular Disease and Adiposity
- Bone health and treatments
- Thyroid Cancer Diagnosis and Treatment
- Parathyroid Disorders and Treatments
- Pancreatic function and diabetes
- Diabetes Management and Research
- Diabetes Treatment and Management
- Adipose Tissue and Metabolism
- Diet and metabolism studies
- Adipokines, Inflammation, and Metabolic Diseases
- Metabolism, Diabetes, and Cancer
- Cardiovascular, Neuropeptides, and Oxidative Stress Research
- Obesity, Physical Activity, Diet
- Nutritional Studies and Diet
- Cardiovascular Function and Risk Factors
- Bone health and osteoporosis research
- Eating Disorders and Behaviors
- Food composition and properties
- Bone Metabolism and Diseases
- Metabolomics and Mass Spectrometry Studies
- Peroxisome Proliferator-Activated Receptors
- Neuroendocrine Tumor Research Advances
- Thyroid and Parathyroid Surgery
- Liver Disease Diagnosis and Treatment
- Vitamin D Research Studies
Campus Bio Medico University Hospital
2024
Università Campus Bio-Medico
2014-2023
IRCCS Policlinico San Donato
2008-2018
Diabetes Australia
2018
Policlinico San Matteo Fondazione
2015
Istituti di Ricovero e Cura a Carattere Scientifico
2015
University of Milan
2010
Although there is an evidence of correlation between irisin and osteoporotic fractures, previous studies have not elucidated the relationship either lean or fat mass. The main aim this study to investigate body composition in postmenopausal women with osteoporosis impact levels on fragility vertebral fractures.In cross-sectional study, 36 overweight subjects affected by at least one fracture confirmed X-ray morphometry nonosteoporotic were enrolled. Serum measured using competitive ELISA. We...
Objective Thyroid ultrasound is crucial for clinical decision in the management of thyroid nodules. In this study, we aimed to estimate and compare performance ATA, AACE/ACE/AME ACR TI-RADS classifications discriminating nodules with high-risk cytology. Design Cross-sectional study. Methods 1077 undergoing fine-needle aspiration were classified according by an automated algorithm. Odds ratios (ORs) receiver operating characteristic (ROC) curves cytology categories (TIR3b, TIR4 TIR5)...
Abstract Context The clinical and radiological aspects of normocalcemic hyperparathyroidism (NHPT) are confounded by the differing methods used to rule out secondary small sample size. Objective To assess clinical, biochemical, profile NHPT compared with primary (PHPT) control subjects Design Multicentric cross-sectional study Setting Outpatient clinic Patients 47 NHPT, 41 PHPT, 39 age- sex-matched subjects. Main Outcome Measures Calcium metabolism bone turnover markers (BTMs). Lumbar spine,...
Objective To evaluate whether a school‐based multicomponent educational program could improve adiposity measures in middle‐school adolescents. Methods A non‐randomized controlled pilot study was conducted six state middle schools (487 adolescents, 11‐15 years) townships an urban area around Milan, three ( n = 262 adolescents) being assigned to the intervention group and 225 control group. The two‐school‐year included changes school environment (alternative healthy vending machines, posters)...
Increased expression of receptor for advanced glycation end products (RAGE) in adipose tissue has been associated with inflammation, adipocyte hypertrophy, and impaired insulin signal. Epicardial (EAT), a visceral fat surrounding the myocardium, is potentially involved onset/progression coronary artery disease (CAD). To date, role RAGE EAT not explored much. We examined whether was adiposity metabolic dysfunctions normally found CAD patients. samples were obtained from 33 patients undergoing...
Antibodies specific to oxidative post-translational modifications (oxPTM) of insulin (oxPTM-INS) are present in most individuals with type 1 diabetes, even before the clinical onset. However, antigenic determinants such response still unknown. In this study, we investigated antibody oxPTM-INS neoepitope peptides (oxPTM-INSPs) and evaluated their ability stimulate humoral T cell responses diabetes. We also assessed concordance between neoantigenic peptides.oxPTM-INS was generated by exposing...
Interleukin-15 (IL-15) is a pro-inflammatory cytokine which signals via specific alpha receptor subunit (IL-15Rα). Increased IL-15 level has been observed in cardiovascular patients and immunoreactivity detected at vulnerable atherosclerotic plaques. Due to the association between adipose tissue distribution, inflammation coronary artery disease (CAD), we quantified IL-15Rα CAD with different adiposity distribution evaluated whether epicardial (EAT), visceral fat depot surrounding...
There are no studies evaluating teriparatide for prevention of post-thyroidectomy hypocalcemia.Our objective was to evaluate whether can prevent postsurgical hypocalcemia and shorten the hospitalization in subjects at high risk following thyroid surgery.This a prospective phase II randomized open-label trial.This trial set on surgical ward.Twenty-six (six males, 20 females) with intact PTH lower than10 pg/ml 4 hours after thyroidectomy were included.Subjects (1:1) receive SC administration...
Microvascular complications' risk differs between people with latent autoimmune diabetes in adults (LADA) and type 2 diabetes. We aimed to investigate whether the prevalence of cardiac autonomic neuropathy, a life-threatening complication diabetes, also varies depending on type.In this cross-sectional study, 43 LADA, 80 1 61 were screened for neuropathy recommended tests. Logistic regression models used test differences types adjusting confounders.Cardiac was diagnosed 17 (40%) participants...
"Lipid accumulation product" (LAP) is a continuous variable based on waist circumference and triglyceride concentration previously associated with insulin resistance. We investigated the accuracy of LAP in identifying oral glucose tolerance test (OGTT) abnormalities compared it to homeostasis model assessment resistance (HOMA-IR) population overweight/obese outpatients presenting nondiabetic fasting glucose. studied 381 (male: 23%) adult (age: 18-70 years) Caucasians (body mass index: 36.9 ±...
<b><i>Introduction:</i></b> Thyroid ultrasound (US) is crucial for clinical decision in the management of thyroid nodules. In this cross-sectional study, we aimed to test if evaluation nodules’ vascularization could improve risk stratification ability American College Radiology (ACR) TI-RADS classification system. <b><i>Methods:</i></b> A total 873 nodules undergoing fine-needle aspiration were classified according ACR US classification. Three...
Poor glucose control has been associated with increased mortality in COVID-19 patients type 1 diabetes (T1D).
Objective: To evaluate stent-induced artifacts by 64-row multidetector computed tomography (MDCT). Methods: We studied 26 stented patients with MDCT before conventional coronary angiography (CCA). The CT values were measured. Stents classified as occluded, significant stenosis, nonsignificant or patent. For the patent stents, mean in-stent and out-stent compared; stents 3 mm smaller compared larger than mm. Multidetector was CCA. Results: analyzed 42 stents. At CCA, 34 patent, 5...
We studied the effect of soluble fiber-enriched products on anthropometric and biochemical variables in 30 healthy non-obese, non-diabetic subjects. This was a randomized, controlled crossover, single-blind, dietary intervention study performed for 8 weeks. Subjects received an isocaloric diet with first 4 weeks regular flour following weeks, or vice versa. Weight, height, measures fat distribution (waist, hip circumference), glucose, insulin triglycerides were measured at baseline, after...