A5015479579- COVID-19 Clinical Research Studies
- Cardiac Valve Diseases and Treatments
- Cardiac Structural Anomalies and Repair
- Venous Thromboembolism Diagnosis and Management
- Long-Term Effects of COVID-19
- COVID-19 and healthcare impacts
- Pulmonary Hypertension Research and Treatments
- Cardiac Imaging and Diagnostics
- Congenital Heart Disease Studies
- Cardiovascular Function and Risk Factors
- SARS-CoV-2 and COVID-19 Research
- Coronary Interventions and Diagnostics
- Cardiovascular and exercise physiology
- Blood Coagulation and Thrombosis Mechanisms
- Acute Myocardial Infarction Research
- Cardiac and Coronary Surgery Techniques
- Sympathectomy and Hyperhidrosis Treatments
- Corporate Finance and Governance
- Adipokines, Inflammation, and Metabolic Diseases
- Orthopaedic implants and arthroplasty
- Porphyrin Metabolism and Disorders
- Italy: Economic History and Contemporary Issues
- Biochemical Analysis and Sensing Techniques
- Thermal Regulation in Medicine
- Cardiac Arrhythmias and Treatments
IRCCS Policlinico San Donato
2003-2022
Ospedale Papa Giovanni XXIII
2020-2021
University of Milan
2013
Istituti di Ricovero e Cura a Carattere Scientifico
2009
Abstract Background Tocilizumab blocks pro-inflammatory activity of interleukin-6 (IL-6), involved in pathogenesis pneumonia the most frequent cause death COVID-19 patients. Methods A multicenter, single-arm, hypothesis-driven trial was planned, according to a phase 2 design, study effect tocilizumab on lethality rates at 14 and 30 days (co-primary endpoints, priori expected being 20 35%, respectively). further prospective cohort patients, consecutively enrolled after first accomplished,...
Introduction: Aim of the study is to assess occurrence early stage coagulopathy and disseminated intravascular coagulation (DIC) in patients with mild moderate respiratory distress secondary SARS-CoV-2 infection. Materials methods: Data hospitalized from 18 March 2020 20 April were retrospectively reviewed. Two scores for screening (SIC non-overt DIC scores) calculated. The thrombotic complication, death, worsening function requiring non-invasive ventilation (NIV) or admission ICU recorded,...
Interleukin-15 (IL-15) is a pro-inflammatory cytokine which signals via specific alpha receptor subunit (IL-15Rα). Increased IL-15 level has been observed in cardiovascular patients and immunoreactivity detected at vulnerable atherosclerotic plaques. Due to the association between adipose tissue distribution, inflammation coronary artery disease (CAD), we quantified IL-15Rα CAD with different adiposity distribution evaluated whether epicardial (EAT), visceral fat depot surrounding...
The aim of the study was to analyse early and long-term outcomes a consecutive series patients who underwent sequential coronary artery bypass grafting (CABG) compare them with matched population totally arterial revascularized patients.From January 1994 December 1996, 209 total myocardial revascularization at our institution [arterial (ART) group]. In same period, 2097 CABG left internal thoracic on anterior descending great saphenous vein right circumflex branches sequentially [sequential...
Abstract We aimed to investigate the prevalence of pulmonary thromboembolism (PTE) and its association with clinical variables in a cohort hospitalized coronavirus disease 2019 (COVID-19) patients receiving low-molecular-weight heparin (LMWH) at prophylactic dosage. In this retrospective observational study we included COVID-19 LMWH from admission but still referred for lower-limbs venous Doppler ultrasound (LL-US) computed tomography angiography (CTPA) PTE suspicion. A dedicated radiologist...
The placement of temporary epicardial pacing wires (EPWs) at the completion cardiac surgery is a routine procedure in most centres. Complications related to their insertion, removal and retention are infrequent, yet potentially severe, including hemorrhage, tamponade, infection death. Here, we describe an unusual case retained EPW migration.
Myocardial infarction leaves a spectrum of LV shape abnormalities. Surgical Ventricular Restoration(SVR) can be applied to any but there are no data that relates its effectiveness pre-op shape. Aim. To assess cardiac function and survival following SVR in patients with different post-MI Methods. Ninety-eight (69 ± 9yrs) submitted for heart failure and/or angina. was classified by Echo 2CH: Type 1 ( true aneurysm): is geometrically delimited two “borders” identified an abrupt change...
Background. LV-End diastolic volume (EDV) following surgical ventricular restoration (SVR) is highly dependent on induced changes in chamber. Aim. To investigate the role of pre and post-operative EDV SVR cardiac function. Methods. We analyzed 298 patients submitted to an anterior MI. All had echo study post-operatively. was conducted arrested heart using endoventricular sizing. Results. Post-op directly related pre-op EDV, r=0.63; P<.001.The larger greater reduction (average −32%) EF...
Background. Experimental studies and theoretical considerations suggest that reduction of left ventricle (LV) stroke volume (SV) following Surgical Ventricular Restoration (SVR) is a consequence diastolic dysfunction. Aim. To analyze changes in SV SVR assess if related to Patients. 134 consecutive patients submitted for symptoms HF and/or angina. Patients with mitral regurgitation were excluded. Results. improved 43 (54 ± 13 60 15 ml; p 0.0001)-G1- decreased 91 (69 19 48 ml, 0.0001)-G2-. The...