A5034882985- Multiple Myeloma Research and Treatments
- Inflammatory Bowel Disease
- Cancer Mechanisms and Therapy
- RNA Interference and Gene Delivery
- Microscopic Colitis
- Protein Degradation and Inhibitors
- SARS-CoV-2 and COVID-19 Research
- COVID-19 and healthcare impacts
- Immune Cell Function and Interaction
- COVID-19 Clinical Research Studies
- Colorectal Cancer Screening and Detection
- IL-33, ST2, and ILC Pathways
- Bone health and treatments
- Helicobacter pylori-related gastroenterology studies
- Immunodeficiency and Autoimmune Disorders
- Nanoparticle-Based Drug Delivery
- Eosinophilic Esophagitis
- Autoimmune and Inflammatory Disorders
- Vaccine Coverage and Hesitancy
- Chemokine receptors and signaling
- CAR-T cell therapy research
- Mycobacterium research and diagnosis
- Cardiac tumors and thrombi
- Bone Metabolism and Diseases
- Gastric Cancer Management and Outcomes
Ospedale Annunziata di Cosenza
2019-2025
Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico
2018-2025
Ospedale Maggiore
2021-2025
SGS Germany GmbH (Germany)
2023
Cork University Hospital
2023
University College Cork
2023
University of Milan
2012-2022
IRCCS Policlinico San Donato
2021-2022
Gastroenterology Hospital "Saverio de Bellis"
2022
University of Brescia
2020-2021
Deregulated expression of miRNAs has been shown in multiple myeloma (MM). A promising strategy to achieve a therapeutic effect by targeting the miRNA regulatory network is enforce that act as tumor suppressor genes, such miR-34a.Here, we investigated potential synthetic miR-34a against human MM cells vitro and vivo.Either transient mimics or lentivirus-based miR-34a-stable enforced triggered growth inhibition apoptosis vitro. Synthetic downregulated canonic targets BCL2, CDK6, NOTCH1 at both...
Abstract Skeletal homeostasis relies upon a fine tuning of osteoclast (OCL)‐mediated bone resorption and osteoblast (OBL)‐dependent formation. This balance is unsettled by multiple myeloma (MM) cells, which impair OBL function stimulate OCLs to generate lytic lesions. Emerging experimental evidence disclosing key regulatory role microRNAs (miRNAs) in the regulation suggesting miRNA network as potential novel target for treatment MM‐related disease (BD). Here, we report that miR‐29b...
MicroRNAs (miRNAs) with tumor-suppressor potential might have therapeutic applications in multiple myeloma (MM) through the modulation of still undiscovered molecular pathways. Here, we investigated effects enforced expression miR-29b on apoptotic occurrence MM and highlighted its role context a new transcriptional loop that is finely tuned by proteasome inhibitor bortezomib. In details, vitro growth inhibition apoptosis cells was induced either transient synthetic or stable...
// Maria Teresa Di Martino 1,2 , Annamaria Gullà 1 Eugenia Gallo Cantafio Marta Lionetti 3 Emanuela Leone Nicola Amodio Pietro Hiram Guzzi 4 Umberto Foresta Francesco Conforti 2 Mario Cannataro Antonino Neri Antonio Giordano 5,6 Pierosandro Tagliaferri and Pierfrancesco Tassone 1,2,6 Department of Experimental Clinical Medicine, Magna Graecia University, Catanzaro, Italy Medical Oncology, Tommaso Campanella Cancer Center, Sciences University Milan, Hematology1, IRCCS Policlinico Foundation,...
Abstract Background Tocilizumab blocks pro-inflammatory activity of interleukin-6 (IL-6), involved in pathogenesis pneumonia the most frequent cause death COVID-19 patients. Methods A multicenter, single-arm, hypothesis-driven trial was planned, according to a phase 2 design, study effect tocilizumab on lethality rates at 14 and 30 days (co-primary endpoints, priori expected being 20 35%, respectively). further prospective cohort patients, consecutively enrolled after first accomplished,...
Objective Progressive Supranuclear Palsy (PSP) is a severe neurodegenerative disease characterized by tangles of hyperphosphorylated tau protein and tufted astrocytes. Developing treatments for PSP challenging due to the lack models reproducing its key pathological features. This study aimed model sporadic PSP‐Richardson's syndrome (PSP‐RS) using multi‐donor midbrain organoids (MOs). Methods The MOs were generated pooling induced pluripotent stem cells (iPSCs) from 4 patients with probable...
Abstract Background Linked color imaging (LCI) is a newly developed image-enhancing endoscopy technology that provides bright endoscopic images and increases contrast. We investigated whether LCI improves the detection of neoplastic lesions in right colon when compared with high definition white-light (WLI). Methods Consecutive patients undergoing colonoscopy were randomized (1:1) after cecal intubation into inspection at first pass by or WLI. At hepatic flexure, scope was reintroduced to...
Abstract Background and Aims Endoscopic activity is associated with an increased risk of surgery in patients ulcerative colitis [UC]. Transmural activity, as defined by Milan Ultrasound Criteria [MUC] > 6.2, reliably detects endoscopic UC. The present study aimed to assess UC whether transmural severity a better predictor colectomy compared endoscopy. Methods Consecutive adult were recruited two IBD Referral Centres underwent colonoscopy intestinal ultrasound blinded fashion. need for...
Abstract Background and aims Inflammatory bowel disease (IBD) patients with Clostridioides difficile infection (CDI) are at increased risk of adverse outcomes. Data on fidaxomicin use in IBD remains scarce. We assessed the effectiveness safety for CDI its impact outcomes a large international cohort. Methods Adult ulcerative colitis (UC) or Crohn’s (CD) treated documented were retrospectively included. The primary outcome was recurrence rate within 8 weeks (C. toxin detection CDI-targeted...
Abstract Data regarding double switching from originator infliximab (IFX) to IFX biosimilars in inflammatory bowel diseases (IBDs) are lacking. The purpose of this study was evaluate the safety and efficacy CT‐P13 subsequently SB2 (double switch) patients with IBD. Patients undergoing IFX‐double switch eight Centers Lombardy (Italy) November 2018 May 2019 were retrospectively analyzed. discontinuation rate, incidence type adverse events (AEs), clinical remission rate recorded. A comparison a...
IFNγ-producing ex-Th17 cells ['Th1/17'] were shown to play a key pathogenic role in experimental colitis and are abundant the intestine. Here, we identified characterised novel, potentially colitogenic subset of Th17 intestine patients with Crohn's disease [CD]. Human expressing CCR5 ['pTh17'] co-expressed T-bet RORC/γt produced very high levels IL-17, together IFN-γ. They had gene signature effector distinct from established Th1/17 cells. pTh17 cells, but not associated intestinal...
Lay Summary Upadacitinib has recently been approved for treating Crohn’s disease (CD). Here, we report on the effectiveness and safety of upadacitinib in a cohort patients with difficult-to-treat CD being cared at clinical centers across Italy.
Recent studies suggest that in patients with carpal tunnel syndrome, pathological changes occur the subsynovial connective tissue. Such are non-inflammatory synovial fibrosis and vascular proliferation. Thickening of tendon sheet may cause an increase canal pressure damages to median nerve wrist; however, causes such events still remain be clarified. We examined specimens from 26 operated on for idiopathic syndrome. Analysis included histological, ultrastructural immunohistochemical...
Invariant natural killer T [iNKT] cells perform pleiotropic functions in different tissues by secreting a vast array of pro-inflammatory and cytotoxic molecules. However, the presence function human intestinal iNKT capable immunomodulatory molecules such as IL-10 has never been reported so far. Here we describe for first time IL10-producing [NKT10 cells] lamina propria healthy individuals Crohn's disease [CD] patients.Frequency phenotype NKT10 were analysed ex vivo from specimens [n = 17]...
Abstract Background Indoleamine 2,3 dioxygenase ( IDO ) interferes with immune responses. Host response against Helicobacter pylori is involved in the persistence of infection and its related diseases. Aim To investigate role regulation Th1/Th2 Th17 pathways H. infection. Methods Gastric biopsy samples were taken from 42 patients who underwent endoscopy evaluated for expression by Western blotting. Gastritis was assessed Sydney system score. In a subgroup patients, biopsies treated inhibitor...
A number of available studies have focused on the role mastocytes and their angiogenic factors, such as tryptase expression, in cancer growth a major research objective. Cardiac myxoma is rare neoplasia most common primary tumor heart. The cellular elements cardiac an endothelial phenotype; however, its histogenesis remains unclear. Currently, no correlated pathological characteristics myxomas, cell differentiation vascularization, with factors mast cells. aim present study was to...
Since the outbreak of COVID-19, concerns have been raised as to whether inflammatory bowel disease (IBD) patients under biologic therapy may be more susceptible disease. This study aimed determine incidence and outcomes COVID-19 in a large cohort IBD on therapy.This observational retrospective multicenter collected data about Italy, between February May 2020. The main end-points were (i) assess both cumulative clinical outcome according different agents (ii) compare them with general...