A5027116725- MicroRNA in disease regulation
- Multiple Myeloma Research and Treatments
- Cancer Mechanisms and Therapy
- Epigenetics and DNA Methylation
- Histone Deacetylase Inhibitors Research
- RNA Interference and Gene Delivery
- Platelet Disorders and Treatments
- Heparin-Induced Thrombocytopenia and Thrombosis
- Protein Degradation and Inhibitors
- Hemophilia Treatment and Research
- Cancer therapeutics and mechanisms
- Peptidase Inhibition and Analysis
- Growth Hormone and Insulin-like Growth Factors
- Glioma Diagnosis and Treatment
- Migraine and Headache Studies
- RNA modifications and cancer
- Intramuscular injections and effects
- Regulation of Appetite and Obesity
- Monoclonal and Polyclonal Antibodies Research
- Vestibular and auditory disorders
- Adipose Tissue and Metabolism
- Cardiovascular and exercise physiology
- RNA Research and Splicing
- Estrogen and related hormone effects
- Pneumocystis jirovecii pneumonia detection and treatment
Presidio Ospedaliero
2024
Azienda Ospedaliera Pugliese Ciaccio
2022-2023
University of Palermo
2016
Magna Graecia University
2011-2015
San Salvatore Hospital
2013
Ospedale di Mirano
1999-2009
MicroRNAs (miRNAs) with tumor-suppressor potential might have therapeutic applications in multiple myeloma (MM) through the modulation of still undiscovered molecular pathways. Here, we investigated effects enforced expression miR-29b on apoptotic occurrence MM and highlighted its role context a new transcriptional loop that is finely tuned by proteasome inhibitor bortezomib. In details, vitro growth inhibition apoptosis cells was induced either transient synthetic or stable...
Aberrant DNA methylation plays a relevant role in multiple myeloma (MM) pathogenesis. MicroRNAs (miRNAs) are class of small non-coding RNAs that recently emerged as master regulator gene expression by targeting protein-coding mRNAs. However, miRNAs involvement the regulation epigenetic machinery and their potential use therapeutics MM remain to be investigated. Here, we provide evidence de novo methyltransferases (DNMTs) is deregulated cells. Moreover, show miR-29b targets DNMT3A DNMT3B...
Epigenetic silencing of tumor suppressor genes frequently occurs and may account for their inactivation in cancer cells. We previously demonstrated that miR-29b is a microRNA (miRNA) targets de novo DNA methyltransferases reduces the global methylation multiple myeloma (MM) Here, we provide evidence epigenetic activity leads to promoter demethylation cytokine signaling-1 (SOCS-1), hypermethylated gene. Enforced expression synthetic mimics MM cell lines resulted SOCS-1 gene demethylation, as...
The analysis of deregulated microRNAs (miRNAs) is emerging as a novel approach to disclose the regulation tumor suppressor or promoting pathways in cells. Targeting aberrantly expressed miRNAs therefore promising strategy for cancer treatment. By miRNA profiling primary plasma cells from multiple myeloma (MM) patients, we previously reported increased miR‐125a‐5p levels associated specific molecular subgroups. On these premises, aimed at investigating biological effects triggered by...
// Lavinia Raimondi 1 , Nicola Amodio Maria Teresa Di Martino Emanuela Altomare Marzia Leotta Daniele Caracciolo Annamaria Gullà Antonino Neri 2 Simona Taverna 3 Patrizia D'Aquila 4 Riccardo Alessandro Antonio Giordano 5 Pierosandro Tagliaferri and Pierfrancesco Tassone 1,5 . Department of Experimental Clinical Medicine, Magna Graecia University Medical Oncology Unit, T. Campanella Cancer Center, Salvatore Venuta Campus, Catanzaro, Italy Sciences Milan, Hematology1, IRCCS Policlinico...
A prolonged preoperatory aPTT in children is often the cause of a delay scheduled surgeries and repetition multiple blood tests, with consequent wasting resources significant discomfort for parents. The aim this review to analyze situations which an isolated prolongation found during preoperative evaluation children, especially when it due presence antiphospholipid antibodies, providing readers keys interpret situation possibility correctly evaluate hemorrhagic risk patient.
Vaccination with ChAdOx1 nCoV-19 can result in vaccine-induced immune thrombotic thrombocytopenia (VITT). This phenomenon mimics heparin-induced thrombocytopenia, yet it does not require heparin as a trigger. case report highlights the potentially lifethreatening complication associated nCov-19 vaccine, clinical presentation, diagnostic approach, and treatment. We two cases of after receiving first dose vaccine. attribute these conditions to vaccine due remarkable temporal relationship. The...