A5068390316- Inflammatory Bowel Disease
- Microscopic Colitis
- Autoimmune and Inflammatory Disorders
- Eosinophilic Esophagitis
- Liver Disease Diagnosis and Treatment
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Gastric Cancer Management and Outcomes
- Colorectal Cancer Screening and Detection
- Pregnancy and Medication Impact
- Gastrointestinal Bleeding Diagnosis and Treatment
- Organ Transplantation Techniques and Outcomes
- Liver Diseases and Immunity
- Liver Disease and Transplantation
- Diagnosis and treatment of tuberculosis
- Neuroendocrine Tumor Research Advances
- Radiomics and Machine Learning in Medical Imaging
- Renal Transplantation Outcomes and Treatments
- Gastrointestinal disorders and treatments
- Heat shock proteins research
- Hepatitis C virus research
- Endoplasmic Reticulum Stress and Disease
- Pancreatic and Hepatic Oncology Research
- Celiac Disease Research and Management
- Immunodeficiency and Autoimmune Disorders
- Colorectal Cancer Surgical Treatments
University of Florence
2020-2025
Azienda Ospedaliero-Universitaria Careggi
2020-2025
University of Siena
2022-2025
KU Leuven
2024
International Hellenic University
2022
Jackson and Tull (United States)
2022
Creative Research Enterprises (United States)
2022
Universidade Federal de Santa Maria
2022
Intestinal ultrasound [IUS] is widely accepted as a reliable tool to monitor Crohn's disease [CD]. Several IUS scores have been proposed, but none has formally by international organizations. Our aim here was compare the available regarding their correlation with endoscopic activity.Consenting CD patients undergoing ileocolonoscopy at our Unit between September 2021 and February 2023 were included. Endoscopic activity defined SES-CD ≥ 3 or Rutgeerts score i2b for operated patients. performed...
INTRODUCTION: Patients with ulcerative colitis (UC) receiving immunosuppressive drugs are at substantial risk of colectomy. We aimed to assess the postoperative complications tofacitinib exposure before colectomy in comparison biologics. METHODS: A multicenter, retrospective, observational study was conducted patients UC who underwent total for medically refractory disease, exposed or a biologic surgery. Primary outcome occurrence any complication within 30 (early) and 90 (late) days after...
<b><i>Background:</i></b> Inflammatory bowel disease (IBD) is a chronically relapsing with continuous need for proactive monitoring to decide appropriate treatments and follow-up strategies. To date, gastrointestinal endoscopy histologic examination of biopsies contrast-enhanced imaging are mandatory techniques the diagnosis activity assessment IBD. <b><i>Summary:</i></b> In recent decades, many research efforts in IBD field have been placed on...
Abstract Background Inflammatory bowel disease (IBD) patients with Clostridiodes difficile Infection (CDI) are at increased risk of exacerbations, therapy escalation, colectomy, and mortality. Data on fidaxomicin use in IBD CDI very limited. We aimed to assess the effectiveness safety for its impact outcomes a large retrospective multicenter cohort study. Methods Adult ulcerative colitis (UC) or Crohn’s (CD) episode (positive toxin enzyme immunoassay polymerase chain reaction toxigenic C....
Abstract Background Tobacco is a known risk factor for Crohn’s disease (CD) recurrence after surgery. However, the impact of electronic cigarettes (or vape) and heat-no-burn tobacco products on post-operative unknown. Methods We conducted retrospective study across five centers in Italy. included consecutive patients with CD who underwent ileocolic resections endoscopic reassessment within 3 to 12 months surgery, whom smoking habit surgery before was known. Endoscopic defined as modified...
The International Bowel Ultrasound Segmental Activity Score (IBUS-SAS) is an intestinal ultrasound (IUS) score validated for Crohn's disease, potentially applicable to ulcerative colitis (UC). We aimed confirm the applicability of IBUS-SAS UC, while comparing its performance with other IUS scores. Adult patients UC undergoing colonoscopy were prospectively included and scored both Mayo Endoscopic Subscore (MES) Ulcerative Colitis Index Severity (UCEIS). was performed within 4 weeks...
Abstract Background and aims Inflammatory bowel disease (IBD) patients with Clostridioides difficile infection (CDI) are at increased risk of adverse outcomes. Data on fidaxomicin use in IBD remains scarce. We assessed the effectiveness safety for CDI its impact outcomes a large international cohort. Methods Adult ulcerative colitis (UC) or Crohn’s (CD) treated documented were retrospectively included. The primary outcome was recurrence rate within 8 weeks (C. toxin detection CDI-targeted...
Rectal cancer is a major mortality cause in the United States (US), and its treatment based on individual risk factors for recurrence each patient. In patients with rectal cancer, accurate assessment of response to chemoradiotherapy has increased importance as variety options grown. this scenario, controversial non-operative approach may be considered some whom complete tumor regression believed have occurred. The recommended locally advanced (LARC, T3-4 ± N+) total mesorectal excision (TME)...
Abstract Background The management of postoperative recurrence (POR) in Crohn's disease (CD) after ileo‐colonic resection is a highly debated topic. Prophylactic immunosuppression surgery currently recommended the presence at least one clinical risk factor. Objective Our aim was to determine whether early can be avoided and guided by endoscopy CD patients with only Methods factor for POR, including previous intestinal resection, extensive small intestine (>50 cm), fistulising phenotype,...
Subcutaneous (SC) formulations of infliximab (IFX) and vedolizumab (VDZ) are approved for the treatment inflammatory bowel diseases (IBDs). Our aim was to evaluate effectiveness switching from intravenous (IV) SC IFX VDZ in IBDs.
Abstract Background and Aims During early phases of inflammation, activated neutrophils extrude neutrophil extracellular traps (NETs) in a peptidyl arginine deiminase 4 (PAD4)-dependent manner, aggravating tissue injury remodeling. In this study, we investigated the potential pro-fibrotic properties signaling NETs Crohn’s disease (CD). Methods fibroblasts were labeled on resected ileum from CD patients by multiplex immunofluorescence staining. NETs-treated human primary intestinal analyzed...
Abstract Background Neutrophil extracellular traps (NETs) consist of DNA filaments and cytoplasmic protein granules, extruded by neutrophils after PAD4-dependent activation. NETs release occurs early during inflammation in various immune-related diseases, further aggravating tissue injury contributing to fibrosis. Our aim was investigate the potential profibrotic effect Crohn’s disease (CD). Methods activated fibroblasts were labelled multiplex immunofluorescence staining on unaffected,...
Vedolizumab is a gut-selective anti-integrin (α4β7) antibody for the treatment of inflammatory bowel disease with well-known optimal safety profile. We aimed to compare its risk infections that anti-TNF drugs and ustekinumab in patients both ulcerative colitis Crohn's disease.All undergoing biological at our centre between 2013 2019 were retrospectively included. All infectious complications registered, considering inpatient outpatient events. A comparison exposure-adjusted infection rates...
Inflammatory bowel disease (IBD) can affect young and reproductively active patients. Our aim was to analyze pregnancy outcomes in a large cohort of women with IBD.All at least one were given questionnaire regarding the outcome their pregnancy. They divided into IBD pregnancies controls depending on whether occurred within or over 10 years prior diagnosis IBD.Three hundred questionnaires analyzed for total 478 that led live-born babies. Age conception older than controls. Active smoking more...
In order to analyse temporal trends in vertical transmission rates of human immunodeficiency virus (HIV) and determinant congenital HIV infection Italy, we have considered data from a network hospitals co-operating the Italian Collaborative Study on pregnancy, conducted between 1988 1995. A total 1040 women entered study. The HIV-1 status babies was known 848 cases (81.5%). Transmission were highest period 1988–1991, then tended decrease 1995 rate 9.7 per 100 children (this finding, however,...