A5001716397- Inflammatory Bowel Disease
- Liver Disease Diagnosis and Treatment
- Liver Disease and Transplantation
- Genetics, Aging, and Longevity in Model Organisms
- Microscopic Colitis
- Neurobiology and Insect Physiology Research
- Colorectal Cancer Screening and Detection
- Gastric Cancer Management and Outcomes
- COVID-19 Clinical Research Studies
- Pharmaceutical studies and practices
- Genetics and Physical Performance
- Radiomics and Machine Learning in Medical Imaging
- COVID-19 and healthcare impacts
- Biosimilars and Bioanalytical Methods
- Hepatocellular Carcinoma Treatment and Prognosis
- Physiological and biochemical adaptations
- Immunodeficiency and Autoimmune Disorders
- SARS-CoV-2 and COVID-19 Research
- Hepatitis C virus research
- Sports Performance and Training
- Pregnancy and Medication Impact
- Inflammatory Myopathies and Dermatomyositis
- Environmental Toxicology and Ecotoxicology
- Organ Transplantation Techniques and Outcomes
- Helicobacter pylori-related gastroenterology studies
Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico
2016-2024
Ospedale Maggiore
2023-2024
IRCCS Policlinico San Donato
2017-2022
University of Milan
2016-2022
Sapienza University of Rome
2013-2015
University of Michigan
2009-2012
Declining mobility is a major concern, as well source of health care costs, among the elderly population. Lack primary cause entry into managed facilities, and contributing factor to frequency damaging falls. Exercise-based therapies have shown great promise in sustaining patients, rodent models. However, genetic basis changing physiological responses exercise during aging not understood. Here, we describe first exercise-training paradigm an invertebrate model system. Flies are exercised by...
Abstract Background and Aims Endoscopic activity is associated with an increased risk of surgery in patients ulcerative colitis [UC]. Transmural activity, as defined by Milan Ultrasound Criteria [MUC] > 6.2, reliably detects endoscopic UC. The present study aimed to assess UC whether transmural severity a better predictor colectomy compared endoscopy. Methods Consecutive adult were recruited two IBD Referral Centres underwent colonoscopy intestinal ultrasound blinded fashion. need for...
Summary dTOR (target of rapamycin) and dFoxo respond to changes in the nutritional environment induce a broad range responses multiple tissue types. Both have been demonstrated control rate age‐related decline cardiac function. Here, we show that Eif4e‐binding protein (d4eBP) is sufficient protect long‐term function against up‐regulation dEif4e recapitulate effects high or insulin signaling. We also provide evidence d4eBP acts tissue‐autonomously downstream myocardium, where it enhances...
One of the most pressing problems facing modern medical researchers is surging levels obesity, with consequent increase in associated disorders such as diabetes and cardiovascular disease 1-3. An important topic research into these health involves role endurance exercise a beneficial intervention. Exercise training an inexpensive, non-invasive intervention several results, including reduction excess body fat 4, increased insulin sensitivity skeletal muscle 5, anti-inflammatory antioxidative...
Abstract Data regarding double switching from originator infliximab (IFX) to IFX biosimilars in inflammatory bowel diseases (IBDs) are lacking. The purpose of this study was evaluate the safety and efficacy CT‐P13 subsequently SB2 (double switch) patients with IBD. Patients undergoing IFX‐double switch eight Centers Lombardy (Italy) November 2018 May 2019 were retrospectively analyzed. discontinuation rate, incidence type adverse events (AEs), clinical remission rate recorded. A comparison a...
Nutrient allocation and usage plays an important part in regulating the onset progression of age-related functional declines. Here, we describe a heterozygous mutation Drosophila (dFatp) that alters nutrient distribution multiple aspects physiology. dFatp mutants have increased lifespan stress resistance, altered feeding behavior fat storage, mobility. Concurrently, experience impairment cardiac function. We show endurance exercise reverses lipid storage myocardium deleterious function...
The American Association for the Study of Liver (AASLD) recommends contrast computerized tomography (CT-scan) and magnetic resonance (MRI) to diagnose hepatocellular carcinoma (HCC) arising in cirrhotic patients under semiannual surveillance with abdominal ultrasound (US). A US guided fine needle biopsy (FNB) serves same purpose radiologically undiagnosed tumors incidentally detected nodules cirrhotics outside surveillance. In this population, we evaluated performance radiological diagnosis...
Abstract Background Up to 15% of patients with ulcerative colitis (UC) do not respond medical therapies and ultimately require colectomy for disease control. Baseline endoscopic severity failure achieve healing, as defined by a Mayo Endoscopic Subscore (MES) ≤ 1, following therapy have been associated an increased risk colectomy. Intestinal ultrasound severity, Milan criteria (MUC) score > 6.2, has The aim this study is evaluate compare MES MUC in predicting the need UC. Methods This...
Abstract Background Inflammatory bowel diseases (IBD), including Crohn's disease (CD) and ulcerative colitis (UC), can trigger the onset of depressive anxiety symptoms. The evaluation mental well-being in patients with a chronic medical condition is considered good clinical practice it strongly recommended by World Health Organization. Nevertheless, health not routinely investigated this context for several reasons, lack training healthcare professionals, stigma associated to...
One of the most pressing problems facing modern medical researchers is surging levels obesity, with consequent increase in associated disorders such as diabetes and cardiovascular disease 1-3. An important topic research into these health involves role endurance exercise a beneficial intervention. Exercise training an inexpensive, non-invasive intervention several results, including reduction excess body fat 4, increased insulin sensitivity skeletal muscle 5, anti-inflammatory antioxidative...
Abstract Background We recently described an interleukin(IL)-23-inducible pathogenic subset of CCR6+CXCR3-CCR5+ mucosal T helper (Th)17 cells (pTh17) infiltrating Crohn’s disease (CD) inflamed mucosa and specifically activated in response to Adherent-Invasive Escherichia Coli. pTh17 are functionally phenotypically distinct from CCR6+CXCR3-CCR5- Th17 (cTh17) IL-12-induced CCR6+CXCR3+ Th1/17 subset. Here, we investigated cells' recirculation into the bloodstream, localization intraepithelial...
Abstract Background Subcutaneous (SC) infliximab (IFX) effectively maintains biochemical, clinical and endoscopic remission in inflammatory bowel disease (IBD) with a comparable safety profile to intravenous (IV) formulation. Transmural healing is considered desirable long-term treatment endpoint IBD, especially Crohn’s (CD). Whether switching from SC-IFX transmural IBD still unknown. Methods This preliminary report prospective multicentre cohort study on patients IV-IFX switched SC-IFX....
Abstract Background The administration of biologic drugs in inflammatory bowel diseases (IBD) is increasingly moving from intravenous to subcutaneous formulations. Limited data available on the effectiveness vedolizumab patients switching long-term therapy. aim study was evaluate efficacy and safety after ulcerative colitis corticosteroid-free clinical remission. Methods An observational, multicentre, prospective conducted by Italian Group for IBD Italy (IG-IBD). Ulcerative remission (pMAYO...
Abstract Background In inflammatory bowel disease (IBD), an acute clinical flare may be due to either exacerbation or enteric infection. Thus, it is recommended exclude infections before escalating IBD therapy. this setting, conventional tests identify only a minimal proportion of (i.e. 10%). Whether nucleic acid multiplex can expand the range detected pathogens and increase overall prevalence still matter debate. Methods We performed single-center transversal prospective study at Fondazione...
Abstract Background Despite the increased therapeutic armamentarium for Crohn’s Disease (CD), a relevant proportion of patients fail to respond multiple therapies and ultimately require surgery. Intravenous (IV) infliximab (IFX) reinduction after drug holiday is associated with reduced efficacy both acute delayed infusion reactions, due immunological mechanisms development antidrug antibodies, currently contraindicated. Recently, subcutaneous (SC) formulation IFX has been developed,...
Abstract Background In Italy, the incidence of SARS-CoV-2 infection peaked in April and November 2020, defining two pandemic waves coronavirus disease 2019 (COVID-19). This study compared characteristics outcomes patients with inflammatory bowel (IBD) infections between waves. Methods Observational longitudinal IBD infection. Patients established diagnoses were consecutively enrolled periods: (i) first wave, from 1 March 2020 to 31 May 2020; (ii) second 15 September December 2020. Results We...