A5059027212- Liver Disease Diagnosis and Treatment
- Liver Disease and Transplantation
- Hepatitis C virus research
- Hepatocellular Carcinoma Treatment and Prognosis
- Hepatitis B Virus Studies
- Inflammatory Bowel Disease
- Iron Metabolism and Disorders
- Microscopic Colitis
- Gallbladder and Bile Duct Disorders
- Celiac Disease Research and Management
- Hemoglobinopathies and Related Disorders
- Gastrointestinal disorders and treatments
- Helicobacter pylori-related gastroenterology studies
- Liver Diseases and Immunity
- Eosinophilic Esophagitis
- Biliary and Gastrointestinal Fistulas
- Pancreatitis Pathology and Treatment
- Appendicitis Diagnosis and Management
- Trace Elements in Health
- Viral gastroenteritis research and epidemiology
- Gastroesophageal reflux and treatments
- Organ Transplantation Techniques and Outcomes
- Systemic Sclerosis and Related Diseases
- Ultrasound in Clinical Applications
- Diverticular Disease and Complications
Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico
2016-2025
Ospedale Maggiore
2010-2025
University of Florence
2024
Copenhagen University Hospital
2013-2022
Rigshospitalet
2013-2022
Cochrane
2013-2022
University of Milan
2012-2021
The Royal Free Hospital
2021
University College London
2021
Istituti di Ricovero e Cura a Carattere Scientifico
1994-2019
<h3>Background</h3> The molecular genetic basis of pulmonary arterial hypertension (PAH) is heterogeneous, with at least 26 genes displaying putative evidence for disease causality. Heterozygous variants in the <i>ATP13A3</i> gene were recently identified as a new cause adult-onset PAH. However, contribution risk alleles to child-onset PAH remains largely unexplored. <h3>Methods and results</h3> We report three families novel, autosomal recessive form childhood-onset due biallelic variants....
Contrast-enhanced ultrasound (CE-US), contrast CT scan and gadolinium dynamic MRI are recommended for the characterisation of liver nodules detected during surveillance patients with cirrhosis US.To assess sensitivity, specificity, diagnostic accuracy economic impact all possible sequential combinations imaging techniques in 1-2 cm undergoing US surveillance.64 67 de novo (55 a size cm) were consecutively examined by CE-US, CT, MRI, fine-needle biopsy (FNB) as standard. Undiagnosed...
The prevalence and natural course of chronic hepatitis C virus (HCV) infection was evaluated in 15,250 consecutive pregnant women. rate HCV vertical perinatal transmission also assessed. presence anti-HCV tested by means EIA III confirmed recombinant immunoblot assay III. Alanine transaminase (ALT), anti-human immunodeficiency (HIV), HCV-RNA were during the first month third trimester pregnancy, 6 months after delivery; same tests made all newborns anti-HCV-positive mothers at birth (on cord...
PURPOSE: To determine the accuracy of various ultrasonographic (US) signs for assessment degree liver fibrosis, with histologic results as reference standard. MATERIALS AND METHODS: Three hundred consecutive asymptomatic patients at least 6 months increased levels aspartate aminotransferase and/or alanine underwent US and biopsy. The estimated pretest probability severe fibrosis or cirrhosis was 35%. parameters were investigated: surface nodularity, caudate lobe hypertrophy, pattern hepatic...
Hereditary hemochromatosis in adults is usually characterized by mutations the (HFE) gene on short arm of chromosome 6. Most patients have a substitution tyrosine for cysteine at position 282 (C282Y). We studied large family from Italy that includes persons who hereditary iron-overload condition indistinguishable but without apparent pathogenic HFE gene. performed biochemical, histologic, and genetic studies 53 living members family, including microsatellite analysis 6 direct sequencing
It has been suggested that excess iron may facilitate the occurrence of cancer. Patients with hereditary hemochromatosis (HH) are at high risk developing liver cancer, and studies limited series reported a frequency nonhepatic cancers. To verify whether patients HH higher cancer other malignancies as compared non–iron-related chronic disease (CLD), we analyzed neoplasms in 230 CLD. The were matched by sex, age, duration follow-up (±5 years), severity disease. On enrollment, following...
Two hundred twelve Italian patients with genetic hemochromatosis (181 men, mean age 50 +/- 11 yr; and 31 women, 49 10 yr) were followed for a median period of 44 mo (range = 3 to 218 mo). Alcohol abuse was present in subjects (15%), chronic HBV HCV infection seen 19 (9%) 35 (24%) 145 cases tested, respectively. Twenty-four (11%) had concomitant beta-thalassemia trait. Liver biopsy revealed cirrhosis 146 noncirrhotic pattern the other 66. Perls' stain degree III 37 IV 171 patients. One...
The prevalence of hypertransaminasemia and the effect gluten-free diet (GFD) were evaluated in 158 consecutive adult celiac patients, 127 women 31 men, aged 18 to 68 years (mean, 32). At diagnosis, 67 patients (42%) had raised aspartate and/or alanine transaminase levels (AST ALT; mean, 47 IU/L, range, 30 190; 61 25 470, respectively), whereas 91 normal liver function tests (LFT). Patients with without comparable for epidemiological data, body mass index (18.5 vs. 19.6), severity intestinal...
In a subset of patients attending liver units, chronic increase in serum transaminases may remain undetermined cause despite thorough investigations. On the other hand, elevated levels have been reported about 40% adult celiac patients. To evaluate prevalence subclinical disease with unexplained hypertransaminasemia comparison that general population (0.5%), 140 consecutive increases unknown were tested for antigliadin and antiendomysium IgA antibodies. All positive antibody tests offered...
Patients with hepatocellular carcinoma should be managed a multidisciplinary approach framed in network where all the diagnostic techniques and therapeutic resources are available order to provide optimal level of care. Given this assumption, Coordinating Committee Italian Association for Study Liver nominated panel experts elaborate practical recommendations management aiming provide: (1) homogeneous efficacious staging work-up, (2) best treatment choice tailored patient status tumour stage...
Transient elastography (TE) allows non-invasive evaluation of the severity liver disease in patients with chronic hepatitis C. This procedure, however, warrants further validation setting transplantation (LT), including under follow-up for recurrent C.Tertiary referral hospital.95 (75 males) transplanted end-stage due to C virus.Paired biopsy (LB) and TE were carried out 6-156 (median, 35) months after LT. 40 sequentially evaluated 6-21 apart.Clinical, laboratory graft histological features...
Primary aim was to validate the percentage of intrahepatic cholangiocarcinomas (ICC) which have a contrast vascular pattern at enhanced ultrasound (CEUS) risk misdiagnosis with hepatocellular carcinoma (HCC) and, secondary aim, verify if any characteristics in CEUS helps identify ICC.All ICC on cirrhosis seen three Italian centres (Bologna, Milan and Pavia) between 2003 2011, least another imaging technique (CT or MRI) had been performed, were retrospectively identified. Those patients size...
Several non-invasive tests (NITs) have been developed to diagnose oesophageal varices (EV), including the recent Baveno VI criteria rule out high-risk (HRV). Spleen stiffness measurement (SSM) with standard FibroScan® (SSM@50Hz) has evaluated. However, EV grading could be underestimated because of a ceiling threshold (75 kPa) SSM@50Hz. The aims were evaluate SSM by novel spleen-dedicated (SSM@100Hz) for diagnosis compared SSM@50Hz, other validated NITs and criteria.This prospective...
The changing epidemiology of liver disease, and modifications in the recommended analytical methodology call for a re‐evaluation upper reference limits (URLs) alanine aminotransferase (ALT) levels. Using same approach consolidated 20 years ago to define healthy population, we defined URL newly International Federation Clinical Chemistry (IFCC) standardized test. In cross‐sectional study, examined 21,296 apparently blood donors (age 18‐65 years) calculated sex‐specific by 95th percentile...
To verify the influence of food consistency on satiety mechanisms we evaluated effects same meal in solid–liquid (SM) and homogenized (HM) form sensation, gastric emptying rate plasma cholecystokinin (CCK) concentration. Eight healthy men, aged 21-28 (mean 24·5) years were given two meals (cooked vegetables 250 g, cheese 35 croutons 50 g olive oil 25 total energy 2573 kJ, with water 300 ml) differing only physical state: SM HM. The subjects consumed randomized order non-consecutive days....