A5083979073- Hepatitis C virus research
- Liver Disease Diagnosis and Treatment
- Hepatitis B Virus Studies
- Hepatocellular Carcinoma Treatment and Prognosis
- Hepatitis Viruses Studies and Epidemiology
- Systemic Lupus Erythematosus Research
- Liver Disease and Transplantation
- Monoclonal and Polyclonal Antibodies Research
- Lung Cancer Treatments and Mutations
- Colorectal Cancer Treatments and Studies
- Immunodeficiency and Autoimmune Disorders
- Cancer, Lipids, and Metabolism
- Diabetes and associated disorders
- Chronic Lymphocytic Leukemia Research
- Liver Diseases and Immunity
- Cytomegalovirus and herpesvirus research
- Gastric Cancer Management and Outcomes
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Hematological disorders and diagnostics
- Urologic and reproductive health conditions
- Nephrotoxicity and Medicinal Plants
- Neuroendocrine Tumor Research Advances
- Liver physiology and pathology
- Occupational and environmental lung diseases
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
University of Gothenburg
2021
Sahlgrenska University Hospital
2021
Magna Graecia University
2021
University of Milan
2006-2018
Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico
1994-2018
University Hospital Heidelberg
2013
Heidelberg University
2013
Università degli Studi del Piemonte Orientale “Amedeo Avogadro”
2011
Ospedale Maggiore
2005-2010
Istituti di Ricovero e Cura a Carattere Scientifico
1996-2010
Large databases of consecutive patients followed for sufficiently long periods are needed to establish the rates, chronology, and hierarchy complications cirrhosis as well importance other potential causes liver disease. In accordance with this goal, a cohort compensated due hepatitis C virus (HCV) was 17 years. Two hundred fourteen HCV RNA–seropositive Child-Pugh class A who had no previous clinical decompensation were prospectively recruited up periodic abdominal ultrasound examinations....
Contrast-enhanced ultrasound (CE-US), contrast CT scan and gadolinium dynamic MRI are recommended for the characterisation of liver nodules detected during surveillance patients with cirrhosis US.To assess sensitivity, specificity, diagnostic accuracy economic impact all possible sequential combinations imaging techniques in 1-2 cm undergoing US surveillance.64 67 de novo (55 a size cm) were consecutively examined by CE-US, CT, MRI, fine-needle biopsy (FNB) as standard. Undiagnosed...
To assess whether extended treatment with interferon improves the outcome of hepatitis B e antigen (HBeAg)–negative chronic B, 101 consecutive patients were treated 6 MU alfa 2b 3 times weekly for 24 months. During 68–month study, 30 (30%) had a sustained response ( i.e. , normal serum transaminase levels and undetectable virus DNA by non–polymerase chain reaction [PCR] assays), 15 cleared surface antigen. Twenty–five nonresponders, 16 relapsers, who discontinued considered failures....
Abstract Invariant (inv)NKT cells are a subset of autoreactive lymphocytes that recognize endogenous lipid ligands presented by CD1d, and suspected to regulate the host response cell stress tissue damage via prompt production cytokines. We investigated invNKT during progression chronic viral hepatitis caused B or C virus infection, major human disease characterized diffused hepatic necroinflammation with scarring fibrotic reaction, which can progress toward cirrhosis cancer. Ex vivo...
Chronic infection with the hepatitis delta virus (HDV) is a risk factor for cirrhosis and hepatocellular carcinoma (HCC), but little known whether outcome of predicted by serum markers HDV B (HBV) infection. The aim study was to investigate these correlations in 193 patients chronic who had been followed up median 9.5 years (4.8-19.3). HDV-RNA first measured qualitative in-house nested RT-PCR quantified real-time PCR. RNA levels only appeared significantly associated HCC (univariate...
To assess whether interferon-alpha might prevent non-A, non-B hepatitis from becoming chronic, 45 consecutive patients with transfusion-associated were enrolled in a randomized clinical trial. Thirty-eight had C virus infection, and 7 non-B, non-C hepatitis. Twenty-six (22 HCV) given 3 MU of recombinant 2b three times week for 12 wk, whereas 19 (16 not. Biochemical virological parameters monitored at regular intervals during an 18-mo follow-up. At the end 3-mo therapy, 16 (73%) normal serum...
The hepatitis delta virus (HDV) is a small, defective RNA that requires the presence of B (HBV) for its life cycle. Worldwide more than 15 million people are co-infected with HBV and HDV. Although much effort has been made, early steps HBV/HDV entry process, including hepatocyte attachment receptor interaction still not fully understood. Numerous possible cellular binding partners have described over last years; however, so far only heparan sulfate proteoglycans functionally confirmed as...
To compare the long-term effectiveness and tolerability of lymphoblastoid interferon (IFN-αN1) recombinant alfa 2a (IFN-α2a) in patients with chronic hepatitis caused by C virus (HCV), 234 consecutive HCV-related were randomized prospectively to receive titrated doses (starting dose = 6 million units [MU]) IFN-α2a (n 118) or IFN-αN1 116) for 12 months. HCV RNA was detected reverse- transcription polymerase chain reaction (RT-PCR), quantified branched-DNA (bDNA) assay, genotyped reverse...
Brief Communications15 August 1994Eradication of Hepatitis C Virus RNA after Alpha-Interferon TherapyRaffaella Romeo, MD, Stanislas Pol, PhD, Pierre Berthelot, and Christian Brechot, PhDRaffaella MDFrom the University Milan, Italy Centre Hopitalier Universitaire Necker, Paris, France.Search for more papers by this author, PhDFrom authorAuthor, Article, Disclosure Informationhttps://doi.org/10.7326/0003-4819-121-4-199408150-00008 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload...
Chronic infection with the hepatitis C virus (HCV) may lead to a variety of hepatic lesions from benign inflammation liver cancer, but relationships between and development disease are poorly understood. To assess whether type load pathogenetic importance, 197 Italian carriers various were investigated consecutively. Of these, 187 (95%) patients had serum HCV RNA, by reverse transcription-polymerase chain reaction (RT-PCR) median level 1003 x 10(3) genomic equivalents ml-1 according...
To assess the prevalence of hepatitis C virus (HCV) infection, a community-based study was performed in eastern Gabon on 1172 subjects over 5 years age. The antibodies to HCV (anti-HCV) detected using second-generation enzyme-linked immunosorbent assay (ELISA) and confirmed by an immunoblot (RIBA 2), 6.5%. Anti-HCV increased with age but related neither sex nor ethnic group. Among 30 positive ELISA results, 14 had viraemia as shown polymerase chain reaction (11/12 RIBA positive, 2/15...
Background and aimsSorafenib is the standard of care for patients with advanced hepatocellular carcinoma (HCC), yet treatment safety may be challenged by portal hypertension. We therefore assessed prevalence, risk factors clinical consequences esophageal varices (EVs) in sorafenib-treated HCC. MethodsStarting 2008, all compensated or intermediate HCC not eligible other therapies were consecutively enrolled a prospective evaluation sorafenib therapy, pretreatment upper-gastrointestinal...
A recently discovered DNA virus, TT virus (TTV), is prevalent in humans. In the present study, genetic heterogeneity of TTV was evaluated hepatitis C (HCV)-infected patients and chimpanzees. detected by PCR serum samples from all ten HCV-infected studied; at least five major genotypes, previously identified humans, were recovered. Eight infected with multiple variants TTV. 11 (65%) 17 naive chimpanzees bred captivity; a persistent infection three six animals. At more than one variant....
The pattern of hepatitis C virus (HCV) viremia in blood donors who are positive for antibody to HCV (anti‐HCV) according the level transaminase activity is unclear. A polymerase chain reaction‐based RNA detection method was used study two clearly defined groups anti‐HCV‐positive with repeatedly normal (n = 27) and elevated 17) alanine aminotransferase (ALT) levels. detected only 4 27 ALT values 15 17 values. These results indicate that levels constitute a heterogeneous group, as detectable...
Twenty-five per cent of haemodialysed patients carry anti-HCV antibodies; these antibodies are associated with detectable viraemia in 85% and chronic hepatitis 90% subjects, despite normal transaminases more than half them. This underlines the importance antiviral therapy. We evaluated tolerance effectiveness a classic interferon (IFN) treatment (3 MU three times week for 6 months, subcutaneously) 19 haemodialysis presenting (n = 16) or acute 3) hepatitis. Thirteen those had elevated...
Summary. The efficacy and tolerability of 12‐month treatment with titrated doses recombinant interferon‐α2a (IFN‐α2a) in chronic hepatitis C were studied 67 consecutively recruited patients randomly assigned either to a starting dose IFN‐α2a 6 MU, subsequently adjusted the serum alanine aminotransferase (ALT) response ( n = 35), or no therapy 32; controls). End‐of‐treatment ALT levels normal virus (HCV) RNA was negative by nested polymerase chain reaction (PCR) 17 (49%) treated compared none...