A5091469218- SARS-CoV-2 and COVID-19 Research
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- COVID-19 Clinical Research Studies
- Immunotherapy and Immune Responses
- SARS-CoV-2 detection and testing
- Sarcoidosis and Beryllium Toxicity Research
- Lipoproteins and Cardiovascular Health
- Parkinson's Disease Mechanisms and Treatments
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Osteoarthritis Treatment and Mechanisms
- Alzheimer's disease research and treatments
- Respiratory viral infections research
- Virology and Viral Diseases
- Rheumatoid Arthritis Research and Therapies
- RNA Interference and Gene Delivery
- Curcumin's Biomedical Applications
- Pharmacological Effects of Medicinal Plants
- Lipid metabolism and disorders
- Liver Disease Diagnosis and Treatment
- Cancer, Lipids, and Metabolism
- Autophagy in Disease and Therapy
- vaccines and immunoinformatics approaches
- Hepatitis C virus research
- Bone health and treatments
- S100 Proteins and Annexins
University of Siena
2023-2025
University of Salento
2023-2024
University of Bari Aldo Moro
2023-2024
Universitat Politècnica de València
2023
La Trobe University
2023
We aimed to describe the limitations of familiar hypercholesterolemia (FH) diagnosis in childhood based on presence typical features FH, such as physical sings cholesterol accumulation and personal or family history premature cardiovascular disease hypercholesterolemia, comparing their prevalence adult paediatric FH population, illustrate how additional information can lead a more effective at younger age.From Italian LIPIGEN cohort, we selected 1188 (≥18 years) 708 (<18...
Influenza D virus (IDV) is a novel orthomyxovirus initially isolated from pigs exhibiting influenza-like disease in the USA. Since then, IDV has been detected worldwide several host species, including livestock animals, whilst specific antibodies have identified humans, raising concerns about interspecies transmission and zoonotic risks. Few data regarding seroprevalence of small ruminants available to date. In this study, we assessed prevalence against ovine serum samples Sicily, Southern...
Parkinson’s disease (PD) is a prevalent neurodegenerative disorder, primarily associated with dopaminergic neuron depletion in the Substantia Nigra. Current treatment focuses on compensating for dopamine (DA) deficiency, but blood–brain barrier (BBB) poses challenges effective drug delivery. Using differentiated SH-SY5Y cells, we investigated co-administration of DA and antioxidant Grape Seed Extract (GSE) to study cytobiocompability, cytoprotection against neurotoxin Rotenone, their...
Sarcoidosis is a rare granulomatous disease that can affect any organ. It leads to an increased risk of metabolic syndrome and insulin resistance, due biochemical pathways involved in low-grade inflammation both diseases. The aim our retrospective case-control study was evaluate the utility triglyceride-glucose (TyG) index, surrogate for assessment sarcoidosis patients. A cohort 90 patients control subjects were enrolled. Clinical, anamnestic, data collected. Results showed TyG index values...
Sarcoidosis is a rare granulomatous disease that can affect any organ; as other chronic diseases, it leads to increased risk of atherosclerosis and cardiovascular (CV) disease. The aim our observational study was define prognostic stratification model sarcoidosis patients based on the evaluation CV through common carotid Doppler ultrasound scores assessment; for this reason, clinical phenotyping in four subgroups done, different organ involvement. A cohort 53 48 healthy volunteers were...
Abstract Aim The present study aimed at assessing the prevalence of antibodies against SARS-CoV-2 in general population province Bari (Apulia region, Southern Italy) during year 2020. Subject and methods In this study, 1325 serum samples collected from January to December 2020 were tested for presence IgM IgG whole-virus antigen by commercial ELISA. Positive further in-house ELISA detection anti-receptor binding domain (RBD) micro-neutralization (MN) assay neutralizing antibody. Results One...
Background: Patients with primary and secondary immunodeficiencies, being more susceptible to infections, are a priority for vaccination. Here, we determined compared the immune response elicited by SARS-CoV-2 vaccination across different cohorts of immunocompromised patients in longitudinal study.Methods: In PatoVac prospective single-center study, spike-specific B cell antibody responses mRNA were haematological haemodialysis patients, hematopoietic stem solid organ transplant recipients...
The Omicron variant is the most divergent, displaying more mutations than previous SARS-CoV-2 variants, particularly in gene that encodes spike protein. This study aimed to assess persistence of neutralizing antibodies towards sublineages (BA.2, BA.5, BQ.1, XBB and XBB1.5) six months after third dose different vaccination regimens. Subjects who received 3 doses mRNA vaccine retained their neutralization activity against BA.2 even though 56.3% 66.7% showed a ≥ 2-fold reduction antibody titre,...
Nature abounds in self-assembling systems that include cell membranes, actin fibres and the flagellum rotor.Nature inspired design attempts to learn from organizing principles of these structures while introducing novel molecular designs.It is highly desirable develop a versatile, small molecule based system incorporates universal self-assembly motif allows seamsless spontaneous assembly functionally different molecules.This concept often described as LEGO system.Here substituted oligoamide...
In the past decade it became accepted that reactive oxygen metabolites (ROM’s) play a role in various tissues damages, thus certain liver deseases as well hepatitis C. Hepatic cells, utilize enzymatic system constituted by glutathione peroxidase/glutathione reductase enzymes (GPX/GR), to reduce oxidative damages. fact, GPX enzyme utilizes GSH ROM’s. Interferon alpha (IFN) might be useful reducing stress, probably through an increase of reduced glutatione (GSH). Recent findings demonstrate C...