A5064271528- Mechanical Circulatory Support Devices
- Cardiac Structural Anomalies and Repair
- Transplantation: Methods and Outcomes
- Cardiovascular Function and Risk Factors
- Pulmonary Hypertension Research and Treatments
- Congenital Heart Disease Studies
- Viral Infections and Immunology Research
- Cardiac Valve Diseases and Treatments
- Cardiac Arrest and Resuscitation
- Renal Transplantation Outcomes and Treatments
- Fuel Cells and Related Materials
- Heart Failure Treatment and Management
- Cardiac Imaging and Diagnostics
- Herpesvirus Infections and Treatments
- SARS-CoV-2 and COVID-19 Research
- Organ Transplantation Techniques and Outcomes
- Immunotherapy and Immune Responses
- RNA Interference and Gene Delivery
- Cardiomyopathy and Myosin Studies
- Cardiovascular Issues in Pregnancy
- Family Support in Illness
- Cardiovascular Disease and Adiposity
- Pneumocystis jirovecii pneumonia detection and treatment
- Bone health and treatments
- Amyloidosis: Diagnosis, Treatment, Outcomes
University of Siena
2014-2025
Ospedale Santa Maria alle Scotte
1998-2024
Azienda Ospedaliera Universitaria Senese
2004-2023
Azienda Ospedaliero-Universitaria Careggi
2022
Nuovo Ospedale di Prato
2022
Istituto di Chimica Biomolecolare
1999
University of Milan
1994
The combination of early transmitral inflow velocity and mitral annular tissue Doppler imaging (E/Em ratio) is widely applied to noninvasively estimate left ventricular (LV) filling pressures. However E/Em ratio has a significant gray zone its accuracy in patients with heart failure debated. Left atrial (LA) deformation analysis by speckle tracking echocardiography (STE) was recently proposed as an alternative approach LV This study aimed at exploring the correlation LA longitudinal function...
In patients with heart failure (HF), chronically raised left ventricular (LV) filling pressures lead to progressive atrial (LA) dysfunction and fibrosis. We aimed assess the correlation of LA reservoir strain (peak longitudinal strain, PALS) by speckle tracking echocardiography (STE) fibrosis assessed myocardial biopsy in undergoing transplantation (HTx).Forty-eight advanced HF [mean age 51.2 ± 8.1 years, 29% females; LV ejection fraction ≤25% New York Heart Association (NYHA) class III-IV]...
Background: The right atrium (RA) plays multiple roles in the cardiac cycle. reservoir phase of RA is a dynamic rather than static cycle and deformation dependent on pulmonary pressures exerted ventricle and, therefore, backwards RA. purpose this study was to assess accuracy clinical applicability speckle tracking echocardiography (STE) evaluation predicting invasive systolic artery pressure (SPAP) patients with heart failure (HF) undergoing catheterization (RHC). Methods: Thirty-one...
Abstract The use of left ventricular assist devices (LVAD) has significantly increased in the last years, trying to offer a therapeutic alternative heart transplantation, light also significant donor shortage compared growing advanced failure population. Despite technological improvements devices, LVAD-related mortality is still fairly high, with right being one predominant predictors. Therefore, many efforts have been made toward thorough (RV) evaluation prior LVAD implant, considering...
Abstract Introduction The transplanted heart (HTX) has pathophysiological differences compared to standard hearts, partially understood. Early detection of abnormal grafts function (e.g. cellular or immune-mediated rejection, coronary artery vasculopathy) by advanced echocardiography can significantly improve management and prognosis HTX patients. Speckle tracking-derived global longitudinal strain (GLS) myocardial work (MW) have lower values in healthy patients controls. How much these...
Right heart failure (RHF) after left ventricular assist device (LVAD) implant is burdened by high morbidity and mortality rates should be prevented appropriate patient selection. Adequate right function of paramount importance but its assessment complex cannot disregard afterload. Myocardial work (MW) a non-invasive Speckle Tracking Echocardiography-derived method to estimate pressure-volume loops. The aim this study was evaluate the performance myocardial predict RHF long-term LVAD...
Advanced heart failure (AdHF) is characterized by variable degrees of left ventricular (LV) dysfunction, myocardial fibrosis, and raised filling pressures which lead to atrial (LA) dilatation cavity dysfunction. This study investigated the relationship between LA peak longitudinal strain (PALS), assessed speckle-tracking echocardiography (STE), invasive measures LV fibrosis in a group AdHF patients undergoing transplantation (HTX).
Bone loss and bone fractures are common complications after organ transplantation. Many factors contribute to the pathogenesis of transplant osteoporosis, such as disease preceding transplantation, immunosuppressive medications, nutritional lifestyle factors. This study aimed assess incidence vertebral before lung heart longitudinal analyzed 213 electronic medical records patients who underwent transplantation (n = 128) 85) at Siena University Medical Center between January 2000 December...
Right ventricular failure (RVF) after left assist device (LVAD) implant is associated with increasing morbidity and mortality. The aim of this study was to identify the best predictors RVF post LVAD-implant among biochemical, haemodynamic echocardiographic parameters. From 2009 2019, 38 patients who underwent LVAD implantation at our centre were prospectively enrolled. Preoperative clinical, laboratory, parameters reported. Overall, eight (21%) developed over time, which revealed be strongly...
Heart transplantation is limited by severe donor organ shortage. Regardless of the changes made in acceptance marginal donors, any such mechanism cannot be considered successful unless recipient graft survival rates remain acceptable. A stress echo-driven selection donors has proven older with normal left ventricular resting function and standard reversible dysfunction acutely improving during stress, or slowly (over hours) intensive hormonal treatment. Aim this study to assess medium-term...
The implantation of left ventricular assist devices (LVADs) has been increasing, with good long-term results, in parallel a growing population advanced heart failure (HF). However, some European countries, LVADs are still underused, one the main issues being patient's late referral. On contrary, use transcatheter edge-to-edge mitral valve repair (TEER) exponentially increased over past decade, expanding its potential even patients on transplantation waiting list. Even though study...