A5066872112- Cardiovascular Function and Risk Factors
- Cardiac Structural Anomalies and Repair
- Cardiac Valve Diseases and Treatments
- Mechanical Circulatory Support Devices
- Cardiac Imaging and Diagnostics
- Immune Cell Function and Interaction
- Generative Adversarial Networks and Image Synthesis
- Cancer Immunotherapy and Biomarkers
- Aesthetic Perception and Analysis
- Computer Graphics and Visualization Techniques
- Image Processing Techniques and Applications
- Trace Elements in Health
- Heart Failure Treatment and Management
- Diverse academic and cultural studies
- Liver Diseases and Immunity
- Management, Economics, and Public Policy
- Music and Audio Processing
- Advanced Measurement and Detection Methods
- Advanced Vision and Imaging
- T-cell and B-cell Immunology
- Pediatric Hepatobiliary Diseases and Treatments
- Cardiovascular Health and Disease Prevention
- Liver Disease Diagnosis and Treatment
- Neurogenetic and Muscular Disorders Research
- Sarcoidosis and Beryllium Toxicity Research
Age UK
2022-2023
GlaxoSmithKline (United Kingdom)
2023
Imperial College London
2017-2021
In patients with heart failure (HF), chronically raised left ventricular (LV) filling pressures lead to progressive atrial (LA) dysfunction and fibrosis. We aimed assess the correlation of LA reservoir strain (peak longitudinal strain, PALS) by speckle tracking echocardiography (STE) fibrosis assessed myocardial biopsy in undergoing transplantation (HTx).Forty-eight advanced HF [mean age 51.2 ± 8.1 years, 29% females; LV ejection fraction ≤25% New York Heart Association (NYHA) class III-IV]...
Abstract Background Cholestatic pruritus and fatigue are debilitating conditions associated with primary biliary cholangitis (PBC) can significantly impact patients’ quality of life. Pruritus in PBC often worsens at night patients frequently report sleep disturbance, which contributes to cognitive symptoms fatigue. Linerixibat is an ileal bile acid transporter inhibitor clinical development for the treatment was recently assessed versus placebo Phase 2b GLIMMER trial. This post-hoc analysis...
<b><i>Background:</i></b> Calcium metabolism alterations are quite common in sarcoidosis and have been correlated with disease activity. <b><i>Objectives:</i></b> The aim of the study was to investigate clinical significance calcium patients chronic sarcoidosis. We paid particular attention associations specific phenotypes chitotriosidase (CTO) expression. <b><i>Methods:</i></b> 212 (mean age 56.07 ± 12 years; 97 males)...
Summary Background Selective depletion of T cells expressing LAG‐3, an immune checkpoint receptor that is upregulated on activated cells, has been investigated in pre‐clinical models as a potential therapeutic approach inflammatory and autoimmune diseases where are implicated. Aims GSK2831781, depleting monoclonal antibody specifically binds LAG‐3 proteins, may deplete + ulcerative colitis (UC). Methods Patients with moderate to severe UC were randomised GSK2831781 or placebo. Safety,...
Abstract There is a growing interest in the use of physical activity data clinical studies, particularly diseases that limit mobility patients. High‐frequency collected with digital sensors are typically summarised into actigraphy features aggregated at epoch level (e.g., by minute). The statistical analysis such volume not straightforward. general trend to derive metrics, capturing specific aspects activity, condense (say) week worth single numerical value. Here we propose analyse entire...
Conditional generative adversarial networks (CGANs) are a recent and popular method for generating samples from probability distribution conditioned on latent information. The information often comes in the form of discrete label small set. We propose novel training CGANs which allows us to condition sequence continuous distributions f (1) , …, ( K ) . This generate distributions. apply our paintings artistic movements, where each movement is considered be its own distribution. Exploiting...
The function of the left atrium (LA) is reduced in many cardiac diseases even with normal size. assessment its compliance could represent an added value echocardiographic report case gold standard technique (speckle-tracking echocardiography [STE]) not available. We sought to test a simple and quick method as surrogate STE: dynamic measurement LA anteroposterior diameter (APD) that we called fractional shortening (LAFS).A total 153 consecutive patients underwent transthoracic our echo...
Abstract This study investigated ethnic differences in the safety, tolerability, pharmacokinetics, and pharmacodynamics of GSK2831781, an anti–lymphocyte activation gene 3 (LAG3) monoclonal antibody, healthy participants, determined local tolerability bioavailability following subcutaneous (SC) administration. A double‐blind, randomized (A) single intravenous (IV) doses GSK2831781 450 mg or placebo Japanese White participants; (B) SC 150 mg, was conducted. Blood samples for analyses were...
Abstract Background For patients with severe mitral regurgitation (MR), new indices are needed to optimize surgical timing before irreversible myocardial dysfunction. Purpose We investigated the prognostic role of left atrial (LA) strain by speckle tracking echocardiography after surgery for MR, and its association LA fibrosis. Methods 70 primary MR undergoing were enrolled. Patients other valvular disease &gt; moderate, bundle branch block, coronary artery disease, heart failure (HF),...
Conditional Generative Adversarial Networks~(CGAN) are a recent and popular method for generating samples from probability distribution conditioned on latent information. The information often comes in the form of discrete label small set. We propose novel training CGANs which allows us to condition sequence continuous distributions $f^{(1)}, \ldots, f^{(K)}$. This generate distributions. apply our paintings artistic movements, where each movement is considered be its own distribution....