A5019373056- Mechanical Circulatory Support Devices
- Cardiac Structural Anomalies and Repair
- Cardiac Valve Diseases and Treatments
- Infective Endocarditis Diagnosis and Management
- Transplantation: Methods and Outcomes
- Cardiac Arrest and Resuscitation
- Aortic Disease and Treatment Approaches
- Cardiac pacing and defibrillation studies
- Congenital Heart Disease Studies
- Cardiac and Coronary Surgery Techniques
- Cardiac, Anesthesia and Surgical Outcomes
- Viral Infections and Immunology Research
- Cardiac Arrhythmias and Treatments
- Electrospun Nanofibers in Biomedical Applications
- Renal Transplantation Outcomes and Treatments
- Infectious Aortic and Vascular Conditions
- Cardiac tumors and thrombi
- Heart Failure Treatment and Management
- Venous Thromboembolism Diagnosis and Management
- Surgical site infection prevention
- Phonocardiography and Auscultation Techniques
- Atrial Fibrillation Management and Outcomes
- Cardiac Imaging and Diagnostics
- Tissue Engineering and Regenerative Medicine
- Tracheal and airway disorders
San Diego Cardiac Center
2016-2024
Azienda Universitaria Ospedaliera Consorziale - Policlinico Bari
2023-2024
Polyclinic General Hospital
2024
University of Bari Aldo Moro
2023-2024
Ospedale Pediatrico Giovanni XXIII
2024
University of Padua
2014-2023
University Hospital of Zurich
2023
University of Zurich
2023
Sahlgrenska University Hospital
2021
University Hospital of Bern
2021
Abstract Background Glutaraldehyde fixation does not guarantee complete tissue biocompatibility in current clinical bioprosthetic heart valves ( BHV s). Particularly, circulating anti‐α G al human antibodies increase significantly from just 10 days after a implantation. The inactivation of such epitope should be mandatory to meet the requirements for perspectively safe application; nevertheless, its quantitative assessment commercially available s has never been carried out. Methods In this...
Bioprosthetic heart valves (BHVs) are commonly used to replace severely diseased but their susceptibility structural valve degeneration (SVD) limits use in young patients. We hypothesized that antibodies against immunogenic glycans present on BHVs, particularly the xenoantigens galactose-α1,3-galactose (αGal) and N-glycolylneuraminic acid (Neu5Gc), could mediate deterioration through calcification. established a large longitudinal prospective international cohort of patients (n = 1668, 34 ±...
BackgroundTranscatheter aortic valve implantation plays a leading role in the management of stenosis patients with comorbidities but no data are available about cardiac rehabilitation these subjects. This study aimed to compare safety and efficacy an early, exercise-based, programme octogenarians after traditional surgical replacement versus transcatheter implantation.
An increased need of extracorporeal membrane oxygenation (ECMO) support is going to become evident as treatment SARS-CoV-2 respiratory distress syndrome. This the first report Italian Society for Cardiac Surgery (SICCH) on preliminary experience with COVID-19 patients receiving ECMO support. Data from 12 hospitals participating in SICCH were retrospectively analyzed. Between March 1 and September 15, 2020, a veno-venous (VV) system was installed 67 (94%) veno-arterio-venous four (6%). Five...
In this study, we assessed the mid-term outcomes of patients who received a heart donation from marginal donor (MD), and compared them with those an organ standard (SD).All underwent HTx between January 2012 December 2020 were enrolled at single institution. The primary endpoints early long-term survival MD recipients. Risk factors for graft failure (PGF) mortality in recipients also analyzed. secondary endpoint was comparison versus SD recipients.In total, 238 HTx, 64 (26.9%) whom MD....
The Extravascular ICD (EV-ICD) is implanted outside of the patient's heart and vascular system. defibrillation lead tunneled in substernal space, very close to surface heart, thus allowing for additional pacing capabilities such as Post Shock Pacing, Anti-Tachycardia Pacing (ATP), Pause Prevention Pacing. Early studies demonstrated safety efficacy profile EV-ICD, but patients with previous or existing cardiac devices leads were excluded. In this case report we describe implantation an EV-ICD...
We report a clinical case of multifactorial shock and primary adrenal insufficiency (PAI), caused by bilateral hemorrhage in the context catastrophic antiphospholipid syndrome (CAPS) triggered COVID-19 infection. A 54-year-old woman was admitted with cardiogenic shock, presenting severe cardiac dysfunction, neurological alterations, systemic embolism. Despite initial treatment for suspected septic her condition deteriorated, hemorrhages, markedly elevated adrenocorticotropic hormone (ACTH)...
The Hancock II (HII) is a second-generation porcine bioprosthesis introduced into clinical use in 1982. This study aimed to evaluate very long-term outcomes for the HII valve large patient population.Between May 1983 and November 1993, 517 consecutive patients (pts) (309 male, mean age: 64+/-9 years) underwent replacement (VR) surgery with HII, 302 (58.4%) aortic VR (AVR) 215 (41.6%) mitral (MVR) position, respectively. At implant, 106 pts (20.5%) were <60 years of age (G1), while 411...
Abstract Limited options do exist for mechanical circulatory support as a bridge to transplantation in the pediatric population. This is especially true when it comes intracorporeal technologies. We describe our successful experience with use of H eartWare ventricular assist devices (HeartWare, Inc., Framingham, MA, USA) three patients <16 years age, and feasible transplant weighing greater than 20 kg.
Sternal wound dehiscence (SWD) after cardiac surgery is a rare but serious condition associated with considerable costs and morbidity. We sought to evaluate the results of introduction vacuum-assisted closure (VAC) therapy in management sternal dehiscence, compared those previous conventional treatments. retrospectively collected 7148 patients who underwent at our institution between January 2002 June 2012. A total 152 (2.1%) had dehiscence: 107 were treated treatments (Group A) 45 managed...
Abstract In this work we aimed to evaluate the evolution of our surgical experience with implantation a continuous flow left ventricular assist device (LVAD), from original full sternotomy approach less invasive strategies including mini‐sternotomy and/or mini‐thoracotomies. We reviewed all consecutive patients implanted LVAD at Institute. To exclude possible bias related used, out 91 collected LVADs implants, selected only those ( n = 42) who received, between 2012 and 2015, HeartWare HVAD....
Abstract Two well‐characterized carbohydrate epitopes are absent in humans but present other mammals. These galactose‐α1,3‐galactose (αGal) and N ‐glycolylneuraminic acid (Neu5Gc) which introduced by the activities of two enzymes including α(1,3) galactosyltransferase (encoded GGTA1 gene) CMP‐Neu5Gc hydroxylase CMAH that inactive cattle. Hence, bovine‐derived products antigenic who receive bioprosthetic heart valves (BHVs) or those suffer from red meat syndrome. Using programmable nucleases,...
In addition to the Evolution RL sheath, tools by Cook Medical (Bloomington, IN, USA), supporting lead extraction (LE), are available. Data on their use not reported in detail previous studies. Moreover, data regarding outcome lacking. The aim was evaluate safety and effectiveness of sheath (Evolution Shortie, Medical) using a stepwise approach with available outcome.A total 393 leads 198 consecutive patients were removed ancillary approach.The main indication for LE infection 125 (63.1%)...