A5024565247- Renal and related cancers
- Genetic and Kidney Cyst Diseases
- Protist diversity and phylogeny
- Fetal and Pediatric Neurological Disorders
University of Perugia
2023
National Institute of Biology
2023
Bursa Uludağ Üni̇versi̇tesi̇
2023
Istanbul Medeniyet University
2021-2023
The correct intraflagellar transport (IFT) assembly at the ciliary base and IFT turnaround tip are key for to perform its function, but we still have poor understanding about how these processes regulated. Here, identify WDR31 as a new protein, analysis from zebrafish Caenorhabditis elegans reveals role of in regulating cilia morphology. We find that loss WDR-31 together with RP-2 ELMD-1 (the sole ortholog ELMOD1-3) results accumulations Complex B components KIF17 kinesin, fewer IFT/BBSome...
Abstract The correct intraflagellar transport (IFT) assembly at the ciliary base and IFT turnaround tip are key for to perform its function, but we still have poor understanding about how these processes regulated. Here, identify WDR31 as a new protein, analysis from zebrafish Caenorhabditis elegans reveals role of in regulating cilia morphology. We find that loss WDR-31 together with RP-2 ELMD-1 (the sole ortholog ELMOD1-3) results accumulations Complex B components KIF17 kinesin, fewer...
Abstract The term “ciliopathy” refers to a group of over 35 rare disorders characterized by defective cilia and many overlapping clinical features, such as hydrocephalus, cerebellar vermis hypoplasia, polydactyly, retinopathy. Even though genes have been implicated in ciliopathies, the genetic pathogenesis certain cases remains still undisclosed. Here, we identified homozygous truncating variant WDR31 patient with typical ciliopathy phenotype encompassing congenital renal agenesis. is an...
Nature abounds in self-assembling systems that include cell membranes, actin fibres and the flagellum rotor.Nature inspired design attempts to learn from organizing principles of these structures while introducing novel molecular designs.It is highly desirable develop a versatile, small molecule based system incorporates universal self-assembly motif allows seamsless spontaneous assembly functionally different molecules.This concept often described as LEGO system.Here substituted oligoamide...