A5055244786- Diabetes Management and Research
- Cardiovascular Health and Disease Prevention
- Cerebrovascular and Carotid Artery Diseases
- Diabetes and associated disorders
- Diabetes Treatment and Management
- Pancreatic function and diabetes
- Cardiovascular Function and Risk Factors
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Blood properties and coagulation
- Blood Pressure and Hypertension Studies
- Cardiovascular Disease and Adiposity
- Adipokines, Inflammation, and Metabolic Diseases
- Coronary Interventions and Diagnostics
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Nutritional Studies and Diet
- Cardiac Imaging and Diagnostics
- Paraoxonase enzyme and polymorphisms
- Heart Rate Variability and Autonomic Control
- Protease and Inhibitor Mechanisms
- Oral microbiology and periodontitis research
- COVID-19 Clinical Research Studies
- Lipoproteins and Cardiovascular Health
- Mobile Health and mHealth Applications
- Venous Thromboembolism Diagnosis and Management
- Liver Disease Diagnosis and Treatment
Magna Graecia University
2016-2025
ORCID
2020
GTx (United States)
2017
Azienda Ospedaliero Universitario Mater Domini
2014-2016
Folded Structures (United States)
2016
Creative Commons
2015
MRC Metabolic Diseases Unit
2012
University of Rome Tor Vergata
1999-2005
University of Teramo
2000
University of Reggio Calabria
1995-1998
Aims The present investigation was designed to test the association between carotid atherosclerosis and two simple markers of insulin resistance, i.e. HOMA-Index TyG-Index. Materials methods study performed in different cohorts. In first cohort, 330 individuals were enrolled. Blood pressure, lipids, glucose, waist cigarette smoking evaluated. HOMA-IR TyG-Index calculated as prevalent hepatic muscular resistance respectively. Carotid assessed by Doppler ultrasonography. cardiovascular risk...
BackgroundONWARDS 6 compared the efficacy and safety of once-weekly subcutaneous insulin icodec (icodec) once-daily degludec (degludec) in adults with type 1 diabetes.MethodsThis 52-week (26-week main phase plus a 26-week extension), randomised, open-label, treat-to-target, 3a trial was done at 99 sites across 12 countries. Adults diabetes (glycated haemoglobin [HbA1c] <10·0% [86 mmol/mol]) were randomly assigned (1:1) to or degludec, both combination aspart (two more daily injections). The...
Atherosclerotic lesions lie in regions of low wall shear stress. No relationship between stress and intima-media thickness vivo has been reported. Aims the present study were to verify reproducibility measurement evaluate its association with common carotid artery healthy subjects.Wall was calculated according following formula: Shear Stress = Blood Viscosity x Velocity/Internal Diameter. viscosity measured by use a cone/plate viscometer. velocity, internal diameter, high-resolution echo...
Background and Purpose It is known that atherosclerosis does not involve both carotid arteries to the same extent. Pathological investigations have demonstrated lesions develop in regions of low wall shear stress. The aims present study were verify degree asymmetry a population-based evaluate whether stress lower carotids with atherosclerotic than without lesions. Methods Participants cardiovascular disease prevention campaign (n=1166) screened for by echo-Doppler examination. Of these, 23...
This study was performed to evaluate the effects of genistein on metabolic and cardiovascular risk factors in Caucasian postmenopausal subjects with syndrome (MetS). Our objective assess surrogate endpoints associated diabetes disease. a randomized, double-blind, placebo-controlled trial at 3 university medical centers Italy. Patients included 120 women MetS according modified Third Report National Cholesterol Education Program (NCEP), Expert Panel Detection, Evaluation Treatment High Blood...
Common carotid intima-media thickness was measured by B-mode ultrasound imaging in 46 children (mean age, 7.4 years) with serum cholesterol > or = 6.4 mmol/L (mean, 8.25 mmol/L) and 48 < 4.60 mmol/L). Maximum significantly higher hypercholesterolemic than control (0.50 versus 0.47 mm, P .007). Subgroup analysis showed that only 6.2 years old (the median of all the children's ages) maximum (0.51 0.48 .014). The odds ratio (OR) common thickening (maximum far wall 95th percentile group, 0.51...
Several studies suggest that genetic factors may play a role in the different responses to antidiabetic therapy; however, conclusive evidence is still lacking.The objective of study was investigate whether diabetic patients carrying E23K variant KCNJ11 are at increased risk for secondary sulfonylurea failure.Secondary failure defined as fasting plasma glucose greater than 300 mg/dl despite sulfonylurea-metformin combined therapy and appropriate diet, absence other conditions causing...
Blood viscosity (BV) is higher in diabetic patients and might represent a risk factor for the development of insulin resistance type 2 diabetes. However, data subjects with normal glucose or prediabetes are missing. In current study, we evaluated relationship between BV blood prediabetes.Enrolled were divided into three groups according to glucose: group A (n = 74), <90 mg/dL; B 96), ranging from 90 99 C 94), 100 125 mg/dL. was measured at 37°C cone-plate viscometer shear rates 225 22.5...
Abstract —The localization of atherosclerotic lesions is influenced by hemodynamic factors, namely, shear stress and tensive forces. The present study investigated the relationships between circumferential wall tension these factors intima-media thickness (IMT) common carotid artery in healthy men. Fifty-eight subjects were studied. Shear was calculated as blood viscosity×blood velocity/internal diameter. Circumferential pressure×internal radius. Blood velocity, internal diameter, IMT...
To verify whether carotid arterial intimal plus media thickness (IMT) is greater in non-insulin-dependent diabetes mellitus (NIDDM) subjects, known to be at high risk for atherosclerosis. Evidence growing that IMT increased subjects with coronary heart disease (CHD) factors like hypercholesterolemia and cigarette smoking.Fifty-four NIDDM 54 sex- age-matched control underwent CHD assessment echo-Doppler examination of arteries. was measured by computer technique the common artery (CCA)....
Background and Purpose— Systemic local coronary heart disease (CHD) risk factors participate in atherogenesis. The role of wall shear stress, a major factor, remains to be elucidated. Methods— Two hundred thirty-four subjects were carefully characterized for the presence hypertension, hyperlipidemia, diabetes mellitus, obesity, cigarette smoking divided into low- high-risk groups. They underwent echo-Doppler examination carotid arteries. Atherosclerotic plaques stenoses detected,...
Abstract —A common variant in the promoter of human stromelysin gene, causing reduced enzyme expression, has been associated with progression coronary atherosclerosis. On other hand, increased activity may promote plaque rupture. The present study was undertaken to investigate relationship between genetic variation gene and carotid geometry. Forty-two healthy male subjects without major heart disease risk factors were investigated. polymorphism studied through polymerase chain reaction...
The relationship between hyperlipidemia and blood plasma viscosity is not completely clear. While increasing often reported with lipids, lipid-lowering treatments are unable to normalize the values. Aim of this study try clarify lipids viscosity.Apparently healthy subjects were enrolled (n = 410). Smokers, diabetics, obese, hypertriglyceridemic (above 400 mg/dl) excluded. Blood (at shear rate 225/s) measured at 37°C. Erythrocyte rigidity (Tk) was calculated according Dintenfass. glucose by...
The GLP-1 receptor agonist exenatide has been approved for adjunctive treatment of type 2 diabetes. Continuous infusion improves endothelial function in vivo; no evidence about a beneficial effect on vascular published. aim our observational study was to evaluate whether would improve brachial artery evaluated by the flow mediated dilation (FMD) technique, compared with glimepiride, subjects FMD time course assessed ultrasound, after 5 min forearm ischaemia, at baseline and 16-week...
Previous data have suggested that genistein could exert beneficial effects on endothelial function and predictors of cardiovascular risk in healthy postmenopausal women. In a randomized clinical trial, we studied the women with metabolic syndrome (MS).Twenty MS, according to modified NCEP-ATP III criteria were randomly assigned receive placebo or (54 mg/day) for 6 months, along Mediterranean-style diet. Postmenopausal without MS (n = 15), served as controls. The primary goal was assessment...
Cardiovascular protection following empagliflozin therapy is not entirely attributable to the glucose lowering effect. Increased hematocrit might influence shear stress that main force acting on endothelium, regulating its anti-atherogenic function. We designed study with aim of investigating effect blood viscosity and in carotid arteries. A secondary endpoint was artery wall thickness. The a non-randomized, open, prospective cohort including 35 type 2 diabetic outpatients who were offered...
Background: The use of real-time continuous glucose monitoring (rtCGM) systems has proved to positively impact the management type 1 diabetes with potential lower HbA1c, reduce frequency and time spent in hypoglycemia, glycemic variability. Nevertheless, acceptance rtCGM remains below expectations dropout rate within first year been reported be 27%. Besides financial reasons due limited reimbursement, include need for frequent sensor replacement, discomfort wearing a sensor, presence adverse...
This document aims to clarify the position of scientific societies and associations people with diabetes regarding use Do It Yourself (DIY) software algorithms approved only by FDA, but not yet European/Italian regulatory agency. DIY systems are already used in Italy technical support is offered web community, important medical-legal issues. The describes most technologies briefly illustrates different algorithms; a paragraph has been inserted issues linked these particular focus on Italian...