A5014886128- Adrenal and Paraganglionic Tumors
- Adipose Tissue and Metabolism
- Pituitary Gland Disorders and Treatments
- Esophageal and GI Pathology
- Colorectal Cancer Surgical Treatments
- Gastric Cancer Management and Outcomes
- Cancer, Hypoxia, and Metabolism
- COVID-19 and healthcare impacts
- Cardiac, Anesthesia and Surgical Outcomes
- Foreign Body Medical Cases
- Hormonal Regulation and Hypertension
- Adipokines, Inflammation, and Metabolic Diseases
- Hernia repair and management
- Colorectal Cancer Screening and Detection
- Cancer, Lipids, and Metabolism
- Congenital Anomalies and Fetal Surgery
- Growth Hormone and Insulin-like Growth Factors
- Gastrointestinal disorders and treatments
- Adrenal Hormones and Disorders
- Pediatric Hepatobiliary Diseases and Treatments
- Neonatal Respiratory Health Research
- Cancer-related molecular mechanisms research
- Abdominal Surgery and Complications
- Appendicitis Diagnosis and Management
- Lipid metabolism and biosynthesis
Hospital Universitari de Girona Doctor Josep Trueta
2005-2025
Institut d'Investigació Biomèdica de Girona
2009-2024
University of Girona
2020-2024
Centro de Investigación Biomédica en Red
2013
Instituto de Salud Carlos III
2013
Instituto de Investigaciones Biomédicas Sols-Morreale
2009
Universidad Autónoma de Madrid
2009
Consejo Superior de Investigaciones Científicas
2009
General Department of Preventive Medicine
2007-2008
Background Potential regulators of adipogenesis include microRNAs (miRNAs), small non-coding RNAs that have been recently shown related to adiposity and differentially expressed in fat depots. However, date no study is available, our knowledge, regarding miRNAs expression profile during human adipogenesis. Thereby, the aim this was investigate whether miRNA pattern cells subcutaneous adipose tissue associated obesity co-morbidities adipocytes linked Methodology/Principal Findings We...
Intestinal perforation due to foreign body (FB) ingestion is rare (1%). We describe our experience in treating these lesions surgically.From 1995 2006, data were collected prospectively 33 patients (18 women and 15 men; mean age 64 years) operated on for intestinal an ingested FB. The type of object, preoperative diagnosis, site, treatment, morbidity mortality reviewed.Foreign was predominantly involuntary (88%). time from 10.4 days. most frequently objects dietary FB (n = 21) toothpicks 6)....
Contradictory findings regarding the gene expression of main lipogenic enzymes in human adipose tissue depots have been reported. In this cross-sectional study, we aimed to evaluate mRNA fatty acid synthase (FAS) and acetyl-CoA carboxilase (ACC) omental subcutaneous (SC) fat from subjects who varied widely terms body mass. FAS ACC were evaluated by real time-PCR 188 samples visceral which obtained during elective surgical procedures 119 women 69 men. Decreased sex-adjusted (-59%) (-49%)...
The discovery of foreign bodies (FB) in the rectum is an infrequent clinical problem. Most commonly, FB are introduced through anal passage or reach after oral ingestion. We describe our experience diagnosis and treatment retained rectum.From 1997 to 2004, data were collected prospectively 30 patients (20 men 10 women; median age 42.5 years). Extraction method, size type object, postextraction evolution reviewed.The was anally 16 cases by ingestion 14. Principal associated factors were:...
Despite growing evidence, the mechanisms connecting adipose tissue (AT) function to type 2 diabetes (T2DM) remain incompletely understood. A detailed analysis of AT transcriptomes could offer valuable insights into this relationship. Here, we examined gene expression patterns in bulk subcutaneous AT, focusing on biological pathways and cellular composition associated with glycated haemoglobin (HbA1c) levels. transcriptomic dataset was obtained from samples 901 adults collected during...
The aims of this work were to evaluate thyroid hormone receptor-alpha (TR alpha), TR alpha 1, and 2 mRNA gene expression 1:TR ratio, identified as candidate factors for explaining regional differences between human adipose tissue depots. alpha, levels, the expressions arginine-serine-rich, splicing factor (SF2), heterogeneous nuclear ribonucleoprotein H1 (hnRNP H1), A1 A1), Spot 14 (S14) evaluated in 76 paired samples obtained from a population 38 women who varied widely terms obesity body...
Caveolins are 21-24 kDa integral membrane proteins that serve as scaffolds to recruit numerous signaling molecules. Specific subclasses of caveolae carry out specific functions in cell metabolism. In particular, triglycerides synthesized at the site fatty acid entry one these classes.We studied expression caveolin-1 (CAV-1) gene association with metabolic variables 90 visceral and 55 subcutaneous adipose tissue samples from subjects a wide range fat mass, stromovascular fraction (SVC)...
<b><i>Introduction:</i></b> Obesity is usually considered a risk factor for surgical complications. Laparoscopic adrenalectomy has replaced open as the standard operation adrenal tumors. <b><i>Objective:</i></b> To compare safety of laparoscopic to treat tumors in obese versus nonobese patients. <b><i>Methods:</i></b> This observational cohort study analyzed consecutive patients who underwent with lateral transperitoneal...
Context Expression and activity of the main lipogenic enzymes is paradoxically decreased in obesity, but mechanisms behind these findings are poorly known. Breast Cancer 1 (BrCa1) interacts with acetyl-CoA carboxylase (ACC) reducing rate fatty acid biosynthesis. In this study, we aimed to evaluate BrCa1 human adipose tissue according obesity insulin resistance, vitro cultured adipocytes. Research Design Methods gene expression, total phosphorylated (P-) BrCa1, ACC were analyzed samples...
Obesity is characterized by the immune activation that eventually dampens insulin sensitivity and changes metabolism. This study explores impact of different inflammatory/ anti-inflammatory paradigms on expression toll-like receptors (TLR) found in adipocyte cultures, adipose tissue, blood.We evaluated real time PCR acute surgery stress vivo (adipose tissue) macrophages (MCM) vitro (adipocytes). Weight loss was chosen as an model, so TLR were analyzed fat samples collected before after...
Summary A diagnosis of bilateral pheochromocytoma warrants exclusion hereditary pheochromocytoma. Objective To describe the first case a associated with V804M mutation in RET proto‐oncogene. Patients The index was 54‐year‐old man adrenal masses discovered during CT scan performed for other reasons. Measurements Genetic analysis included exons 8–11 and 13–17 proto‐oncogene, all four flanking intronic regions SDHD gene, eight SDHB , three VHL gene. Results Investigations revealed elevated...
Although accidental ingestion of foreign bodies is a common problem in the general population, most objects pass through entire digestive tract without incidents (1). However, 1% cases, it causes complications such as acute abdomen due to intestinal perforation (2). In some can cause severe and even death; USA, 1,500 people die annually from body (3).
<i>Background:</i> Gastric rupture due to abdominal trauma is rare (0.02–1.7%); it usually caused by traffic accidents. Delayed diagnosis, contamination and associated lesions cause morbidity mortality. <i>Patients Methods:</i> Retrospective review of 2,083 patients with traumatism treated at our center over 20 years. We reviewed recent ingestion a meal, etiology, time surgery, site, Stomach Injury Scale, contamination, treatment, injuries, complications...
New techniques are being developed to improve the results of laparoscopic surgery for rectal cancer. This paper analyzes learning curves transanal total mesorectal excision (taTME) and robot-assisted in our colorectal department. We analyzed retrospectively data from patients undergoing curative elective cancer ≤12 cm anal verge. excluded extended surgeries. used cumulative sum (CUSUM) curve analysis identify inflection points. Between 2015 2021, 588 underwent at center: 67 taTME 79 To...