A5010824199- Bariatric Surgery and Outcomes
- Liver Disease Diagnosis and Treatment
- Diet and metabolism studies
- Body Contouring and Surgery
- Diet, Metabolism, and Disease
- Adipokines, Inflammation, and Metabolic Diseases
- Regulation of Appetite and Obesity
- Lipid metabolism and disorders
- Adipose Tissue and Metabolism
- COVID-19 and healthcare impacts
- Obesity and Health Practices
- Esophageal and GI Pathology
- Surgical Simulation and Training
- Peroxisome Proliferator-Activated Receptors
- Metabolomics and Mass Spectrometry Studies
- Gastric Cancer Management and Outcomes
- Anatomy and Medical Technology
- Pharmacology and Obesity Treatment
- Cardiovascular Disease and Adiposity
- Lipid metabolism and biosynthesis
- Gastrointestinal disorders and treatments
- Gastrointestinal motility and disorders
- Inflammatory Bowel Disease
- IgG4-Related and Inflammatory Diseases
- Cholesterol and Lipid Metabolism
Institut d'Investigació Sanitària Pere Virgili
2015-2024
Universitat Rovira i Virgili
2015-2024
Agència de Gestió d'Ajuts Universitaris i de Recerca
2020-2024
Hospital Universitari Sant Joan de Reus
2015-2024
Sociedad Española de Cirugía Ortopédica y Traumatología
2020-2022
Abstract Background Vaspin and omentin are recently described molecules that belong to the adipokine family seem be related metabolic risk factors. The objectives of this study were twofold: evaluate vaspin circulating levels mRNA expression in subcutaneous visceral adipose tissues non-diabetic morbidly obese women; assess relationship with anthropometric parameters, other adipo/cytokines. Design We analysed 71 women European descent (40 [BMI ≥ 40 kg/m 2 ] 31 lean ≤ 25]). assessed gene...
Objective The adipocyte/macrophage fatty acid-binding protein 4 (FABP4) has been described as a biomarker for adiposity and metabolic syndrome (MS). aims of this study were to assess the relationship between FABP4 inflammatory cytokines related obesity, evaluate mRNA expression in visceral subcutaneous adipose tissue non-diabetic morbidly obese women versus healthy lean women. Methods We analyzed circulating levels 81 Spanish women: 38 (body mass index (BMI)<25 kg/m 2 ) 43 (BMI>40 )....
Abstract Background Low concentrations of plasma vitamin D (25(OH)D) have been associated with the development metabolic syndrome (MetS), obesity, diabetes and cardiovascular disease. The objective this study was to quantify associations between 25(OH)D parathormone (PTH) levels presence MetS, or atherogenic dyslipidemia (AD) in a large sample individuals different degrees adiposity. Methods Retrospective all patients who had attended obesity clinics Spanish hospital 2009 2011, whose PTH,...
Abstract Background/Objectives Non-alcoholic fatty liver disease (NAFLD) causes a wide spectrum of damage, from simple steatosis (SS) to cirrhosis. SS and non-alcoholic steatohepatitis (NASH) cannot be distinguished by clinical or laboratory features. Dysregulation the gut microbiota is involved in NASH pathogenesis. The aim this study was assess relationship between microbiota-derived metabolites degrees NAFLD; also, investigate whether these could included panel biomarkers....
Obesity is a chronic and complex disease, with an increasing incidence worldwide that associated metabolic disorders such as type 2 diabetes mellitus (T2DM). Thus, it important to determine the differences between metabolically healthy obese individuals those disorders. The aim of this study was perform untargeted metabolomics assay in women morbid obesity (MO) compared normal weight group, differentiate metabolome these MO who present T2DM. We carried out liquid chromatography-mass...
Lipid accumulation in the human liver seems to be a crucial mechanism pathogenesis and progression of non-alcoholic fatty disease (NAFLD). We aimed evaluate gene expression different acid (FA) metabolism-related genes morbidly obese (MO) women with NAFLD. Liver key related de novo FA synthesis (LXRα, SREBP1c, ACC1, FAS), uptake transport (PPARγ, CD36, FABP4), oxidation (PPARα), inflammation (IL6, TNFα, CRP, PPARδ) were assessed by RT-qPCR 127 MO normal histology (NL, n = 13), simple...
Specific miRNA expression profiles have been shown to be associated with nonalcoholic fatty liver disease (NAFLD). We examined the correlation between circulating levels and hepatic of miR122 miR33a/b*, key lipid metabolism-related gene clinicopathological factors obese women NAFLD. measured miR33a/b* in samples from 62 morbidly (MO), 30 moderately (ModO), eight normal-weight controls. MiR122 was analyzed by qRT-PCR. Additionally, miR33b* were 122 women. Hepatic increased MO compared ModO...
The progression of nonalcoholic fatty liver disease (NAFLD) to steatohepatitis (NASH) is linked systemic inflammation. Currently, two the aspects that need further investigation are diagnosis and treatment NASH. In this sense, aim study was assess relationship between circulating levels cytokines, hepatic expression toll-like receptors (TLRs), degrees NAFLD, investigate whether these could serve as noninvasive biomarkers present assessed plasma cytokines in 29 normal-weight women 82 with...
Obesity is a multifactorial, chronic, progressive and recurrent disease considered public health issue worldwide an important determinant of disability death. In Spain, its current prevalence in the adult population about 24% estimated 2035 37%. increases probability several diseases linked to higher mortality such as diabetes, cardiovascular disease, hyperlipidemia, arterial hypertension, non-alcoholic fatty liver types cancer, or obstructive sleep apnea. On other hand, although incidence...
Eur J Clin Invest 2011; 41 (3): 308–314 Abstract Background The paraoxonase (PON) enzyme family comprising PON1, PON2 and PON3 are antioxidant enzymes that degrade bioactive oxidised lipids thus antiatherogenic. Materials methods We investigated the localisation of PON proteins during development atherosclerosis by immunohistochemical analysis. Results In normal aortas, PON1 were localised to smooth muscle cells (SMC) endothelial cells. staining was stronger than PON1. During development,...
Summary Objective The controversial results on the physiopathological role of visfatin led us to examine both circulating levels and gene expression in visceral (VAT) subcutaneous fat (SAT) a homogeneous group morbidly obese women. Design, patients measurements We analysed several adipo/cytokines 133 Spanish women: 40 lean (C) [body mass index (BMI) < 25 kg/m 2 ] 93 (MO) (BMI > ). In MO group, we found 31 diabetic 62 nondiabetic subjects. obtained follow‐up blood samples at 6 12 months...
Abstract Objective: We aimed to analyze the retinol binding protein‐4 (RBP4) messenger RNA (mRNA) expression profiles in adipose tissues and liver of morbidly obese (MO) women with or without nonalcoholic fatty disease (NAFLD), study relationships other pro‐ anti‐inflammatory adipokines vivo vitro. Design Methods: performed a cross‐sectional analysis subcutaneous tissue (SAT), visceral (VAT) samples from four lean 45 MO NAFLD by enzyme‐linked immunosorbent assay real‐time reverse...
Abstract Background and Aims The rise in obesity highlights the need for improved therapeutic strategies, particularly addressing metabolic dysfunction‐associated steatotic liver disease (MASLD). We aim to assess role of tryptophan pathways pathogenesis different histological stages MASLD. Materials Methods used ultra‐high performance liquid chromatography quantify circulating levels 15 tryptophan‐related metabolites from kynurenine, indole serotonin pathways. A cohort 76 subjects was...
Lipocalin 2 (LCN2) has been related to obesity, insulin resistance and metabolic disturbance. However, its relation with non alcoholic fatty liver disease (NAFLD) hardly studied. We examined LCN2 circulating levels protein gene expression in from women severe obesity NAFLD. analyzed the histology of 59 white severely obese (BMI ≥40 Kg/m<sup>2</sup>): 15 subjects presented normal or non-significant (NL), 18 simple steatosis (SS) 26 steatohepatitis (NASH). determined anthropometric features...
Objective The aim of this study was to analyse the expression crucial genes in fatty acid metabolism visceral (VAT) and subcutaneous (SAT) adipose tissue samples from morbidly obese women. Methods VAT SAT key 145 women (MO, BMI > 40 Kg/m 2 ) 18 normal weight control by RT‐PCR Western Blot analyzed. Results In SAT, levels related lipogenesis oxidation were significantly lower MO than controls. VAT, most lipogenic studied had similar cohort. Regarding inflammation, IL6 higher both tissues...
Recent studies report the effect of bariatric surgery on glycaemia control and prevention type-2-diabetes in obese patients. This study is about pathophysiological mechanisms associated to these changes.Circulating levels receptors tumor necrosis factor (TNF-RI, TNF-RII), visfatin, high molecular weight (HMW) adiponectin, C reactive protein (CRP) 30 morbidly women (body mass index, BMI>40 kg/m(2) ) 60 normal-weight controls (BMI>25 were analyzed. Morbidly studied at three time-points: before...