A5029364336- Diet and metabolism studies
- Metabolomics and Mass Spectrometry Studies
- Paraoxonase enzyme and polymorphisms
- Adipose Tissue and Metabolism
- Liver Disease Diagnosis and Treatment
- Adipokines, Inflammation, and Metabolic Diseases
- Atherosclerosis and Cardiovascular Diseases
- Metabolism, Diabetes, and Cancer
- Immune Cell Function and Interaction
- Diet, Metabolism, and Disease
- Phagocytosis and Immune Regulation
- Apelin-related biomedical research
- Immunotherapy and Immune Responses
- Biochemical Acid Research Studies
- HIV Research and Treatment
- HIV-related health complications and treatments
- Neuroinflammation and Neurodegeneration Mechanisms
- Immune cells in cancer
- Chemokine receptors and signaling
- Mitochondrial Function and Pathology
- Cytomegalovirus and herpesvirus research
- GDF15 and Related Biomarkers
- Tryptophan and brain disorders
- NF-κB Signaling Pathways
- Natural Antidiabetic Agents Studies
Universitat Pompeu Fabra
2018-2024
Barcelona Biomedical Research Park
2018
Institut d'Investigació Sanitària Pere Virgili
2012-2017
Universitat Rovira i Virgili
2012-2017
Centro de Investigaciones Biológicas Margarita Salas
2017
Consejo Superior de Investigaciones Científicas
2017
Hospital Universitari Sant Joan de Reus
2012-2015
Centro de Investigación Biomédica en Red
2013
Aging can be viewed as a quasi-programmed phenomenon driven by the overactivation of nutrient-sensing mTOR gerogene. mTOR-driven aging triggered or accelerated decline loss responsiveness to activation energy-sensing protein AMPK, critical gerosuppressor mTOR. The occurrence age-related diseases, therefore, reflects synergistic interaction between our evolutionary path sedentarism, which chronically increases number activating gero-promoters (e.g., food, growth factors, cytokines and...
Macrophages integrate information from the tissue microenvironment and adjust their effector functions according to prevalent extracellular stimuli. Therefore, macrophages can acquire a variety of activation (polarization) states, this functional plasticity allows adequate initiation, regulation, resolution inflammatory responses. Modulation glucose metabolism contributes macrophage adaptation surrounding cytokine milieu, as exemplified by distinct catabolism exposed LPS/IFN-γ or IL-4. To...
MHCII in antigen-presenting cells (APCs) is a key regulator of adaptive immune responses. Expression genes controlled by the transcription coactivator CIITA, itself regulated through cell type-specific promoters. Here we show that factor NFAT5 needed for expression Ciita and macrophages, but not dendritic other APCs. NFAT5-deficient macrophages showed defective activation MHCII-dependent responses CD4+ T lymphocytes attenuated capacity to elicit graft rejection vivo. Ultrasequencing analysis...
Abstract Obesity is associated with low-grade inflammation and elevated levels of circulating saturated fatty acids, which trigger inflammatory responses by engaging pattern recognition receptors in macrophages. Because tissue homeostasis maintained through an adequate balance pro- anti-inflammatory macrophages, we assessed the transcriptional functional profile M-CSF–dependent monocyte-derived human macrophages exposed to concentrations acids found obese individuals. We report that...
Abnormalities in mitochondrial metabolism and regulation of energy balance contribute to human diseases. The consequences high fat other nutrient intake, the resulting acquired dysfunction, are essential fully understand common disorders, including obesity, cancer, atherosclerosis. To simultaneously noninvasively measure quantify indirect markers function, we have developed a method based on gas chromatography coupled quadrupole-time flight mass spectrometry an electron ionization interface,...
Prevention of the metabolic consequences a chronic energy-dense/high-fat diet (HFD) represents public health priority. Metformin is strong candidate to be incorporated in alternative therapeutic approaches. We used targeted metabolomic approach assess changes related multi-faceted disturbances provoked by HFD. evaluated protective effects metformin and explored how pro-inflammatory respond when mice rendered obese, glucose-intolerant hyperlipidemic were switched reversal with or without...
Insulin resistance in viral infections is common. We have explored the effectiveness of metformin for alleviating insulin HIV-infected patients and assessed relevance ataxia-telangiectasia mutated (ATM) rs11212617 variant clinical response with rationale that modulates cellular bioenergetics an ATM-dependent process.HIV-infected (n = 385) were compared controls recruited from general population 300) respect to genotype distribution ATM its influence on selected metabolic inflammatory...
Abstract The ability of innate immune cells to respond pathogen-associated molecular patterns across a wide range intensities is fundamental limit the spreading infections. Studies on transcription responses pathogen-activated TLRs have often used relatively high TLR ligand concentrations, and less known about their regulation under mild stimulatory conditions. We had shown that factor NFAT5 facilitates expression antipathogen genes stimulation conditions corresponding low pathogen loads. In...
Abstract Background Chemokines can block viral entry by interfering with HIV co-receptors and are recognised mediators of atherosclerosis development. A number experimental drugs that inhibit arrest the development in animal models. We hypothesised expression chemokine receptors circulating leukocytes is associated rate progression HIV-infected patients. Methods The increase intima-media thickness during a 2-year follow-up was used to classify patients (n = 178) as progressors 142) or...
Excessive energy management leads to low-grade, chronic inflammation, which is a significant factor predicting noncommunicable diseases. In turn, oxidation, and metabolism are associated with the course of these diseases; mitochondrial dysfunction seems be at crossroads mutual relationships. The migration immune cells during inflammation governed by interaction between chemokines chemokine receptors. Chemokines, especially C-C-chemokine ligand 2 (CCL2), have variety additional functions that...
The role of chemokine (C-C motif) ligand 2 (CCL2) in peripheral artery disease is unclear. We measured the difference between serum and plasma levels CCL2 patients with chronic ischemia threatening lower extremities following observation that atypical receptors blood tissue cells may prevent from entering circulation consequently modulate its function attracting monocytes to site lesion. To identify influence CCL2, we compared patients’ values those bio-banked samples a control population....
ABSTRACT Effector T lymphocytes are avid glucose consumers, but can function in the nutrient-poor environments of tumors. However, availability blood-delivered nutrients throughout tumor is not homogeneous, and how this affects effector cells well known. Here we have isolated tumor-infiltrating (TILs) from mouse solid tumors by their capacity to capture blood-transported probes, compared them with glucose-restricted cells. Glucose restriction vitro arrested cell proliferation reduced only...