A5025821862- Immune Cell Function and Interaction
- T-cell and B-cell Immunology
- Immune cells in cancer
- Protein Degradation and Inhibitors
- Cytokine Signaling Pathways and Interactions
- Multiple Myeloma Research and Treatments
- Psoriasis: Treatment and Pathogenesis
- Biochemical and Molecular Research
- CAR-T cell therapy research
- IL-33, ST2, and ILC Pathways
- Immune Response and Inflammation
- Anodic Oxide Films and Nanostructures
- Cutaneous lymphoproliferative disorders research
- NF-κB Signaling Pathways
- Integrated Circuits and Semiconductor Failure Analysis
- Whipple's Disease and Interleukins
- Cancer Mechanisms and Therapy
- Signaling Pathways in Disease
- Systemic Lupus Erythematosus Research
- Cancer, Hypoxia, and Metabolism
- Phytochemical compounds biological activities
- Immunotherapy and Immune Responses
- Reproductive System and Pregnancy
- T-cell and Retrovirus Studies
- Ubiquitin and proteasome pathways
Inserm
2021-2024
Université de Lille
2021-2024
Centre National de la Recherche Scientifique
2021-2024
Centre Hospitalier Universitaire de Lille
2021-2024
Institut pour la Recherche sur le Cancer de Lille
2021
CANTHER - Hétérogénéité, Plasticité et Résistance aux Thérapies des Cancers
2021
Universitat Pompeu Fabra
2021
University of Genoa
2017-2019
Cytokines interact with their receptors in the extracellular space to control immune responses. How physicochemical properties of influence cytokine signaling is incompletely elucidated. Here, we show that activity interleukin-2 (IL-2), a critical T cell immunity, profoundly affected by pH, limiting IL-2 within acidic environment tumors. Generation lactic acid tumors limits STAT5 activation, effector differentiation, and antitumor immunity CD8
The release of soluble ligands activating Natural Killer (NK) cell receptors may represent a regulatory mechanism NK function both in physiologic and pathologic conditions. Here, we identified the extracellular matrix protein Nidogen-1 (NID1) as ligand NKp44, an important receptor expressed by activated cells. When released molecule, NID1 regulates modulating NKp44-induced IFN-γ production or cytotoxicity. In particular, it also modulates induced Platelet-Derived Growth Factor (PDGF)-DD...
Abstract Daratumumab and lenalidomide (DR) combination therapy has improved outcomes in multiple myeloma (MM), but some patients still experience poor responses. To understand the factors influencing treatment resistance, we performed single-cell RNA sequencing on bone marrow samples from 21 newly diagnosed MM enrolled IFM2017-03 trial, classifying them as complete responders (CR, n=11) or non-/poor (NR, n=10). NR exhibited pro-inflammatory microenvironment (BME) characterized by elevated...
Cytokines elicit pleiotropic and non-redundant activities despite strong overlap in their usage of receptors, JAKs STATs molecules. We use IL-6 IL-27 to ask how two cytokines activating the same signaling pathway have different biological roles. found that induces more sustained STAT1 phosphorylation than IL-6, with inducing comparable levels STAT3 phosphorylation. Mathematical statistical modeling identified binding GP130, IL-27Rα, as main dynamical processes contributing pSTAT1 by IL-27....
Multiple myeloma (MM) is an incurable hematological malignancy in which MYC alterations contribute to the malignant phenotype. Nevertheless, lacks therapeutic druggability. Here, we leveraged large-scale loss-of-function screens and conducted a small molecule screen identify genes pathways with enhanced essentiality correlated
// Alessandra Dondero 1 , Beatrice Casu Francesca Bellora Angelo Vacca 2 Annunziata De Luisi Maria Antonia Frassanito Claudia Cantoni 1, 3, 4 Silvia Gaggero Daniel Olive 5 Alessandro Moretta Cristina Bottino * Roberta Castriconi 4, Department of Experimental Medicine (DIMES), University Genova, 16132 Italy Biomedical Sciences and Human Oncology, Bari, 70124 3 Istituto Giannina Gaslini, 16147 Center Excellence for Research (CEBR), U1068, CRCM, Immunity Cancer, INSERM, 13009 Marseille, France...
Abstract The ability of innate immune cells to respond pathogen-associated molecular patterns across a wide range intensities is fundamental limit the spreading infections. Studies on transcription responses pathogen-activated TLRs have often used relatively high TLR ligand concentrations, and less known about their regulation under mild stimulatory conditions. We had shown that factor NFAT5 facilitates expression antipathogen genes stimulation conditions corresponding low pathogen loads. In...
Mycosis fungoides (MF) is the most prevalent primary cutaneous T-cell lymphoma, with an indolent or aggressive course and poor survival. The pathogenesis of MF remains unclear, prognostic factors in early stages are not well established. Here, we characterized recurrent genomic alterations using whole-exome sequencing 67 samples from 48 patients Lille University Hospital (France), including 18 sequential drawn across malignancy. Genomic data were analyzed on Broad Institute's Terra...
Abstract Cellular immunotherapy has emerged as one of the most potent approaches to treating cancer patients. Adoptive transfer chimeric antigen receptor (CAR) T cells well use haploidentical natural killer (NK) can induce remission in patients with lymphoma and leukemia. Although CAR been established, this approach is currently limited for wider by risk severe adverse events, including cytokine release syndrome immune effector cell‐associated neurotoxicity syndrome. Moreover, triggering...
ABSTRACT Cytokines elicit pleiotropic and non-redundant activities despite strong overlap in their usage of receptors, JAKs STATs molecules. We use IL-6 IL-27 to ask how two cytokines activating the same signaling pathway have different biological roles. found that induces more sustained STAT1 phosphorylation than IL-6, with inducing comparable levels STAT3 phosphorylation. Mathematical statistical modelling identified binding GP130, IL-27Rα, as main dynamical processes contributing pSTAT1...
Background: Multiple myeloma (MM) is an incurable hematological malignancy characterized by a proliferation of clonal plasma cells in bone marrow. MM progresses from precursor stages, named monoclonal gammopathy undetermined significance (MGUS) and smoldering (SMM), to the symptomatic myeloma, MM. MYC abnormalities play critical role disease progression. However, not therapeutically targetable due its nuclear localization short half-life protein. Aims: To overcome this, we hypothesized that...